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    (+)-Nortrachelogenin
    (+)-Nortrachelogenin
    Information
    CAS No. 61521-74-2 Price
    Catalog No.CFN96714Purity>=98%
    Molecular Weight374.38Type of CompoundLignans
    FormulaC20H22O7Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: (+)-Nortrachelogenin is moderately active against HIV-1 in vitro; it also can induce morphological deformation of P. oryzae mycelia with the MMDC value of 31.3 +/- 1.8 microM. (+)-Nortrachelogenin shows effects on the central nervous system producing depression in rabbits.
    Targets: HIV | Antifection
    In vitro:
    Lloydia. 1979 Mar-Apr;42(2):159-62.
    (+)Nortrachelogenin, a new pharmacologically active lignan from Wikstroemia indica.[Pubmed: 449625]

    METHODS AND RESULTS:
    A new lignan, (+)-Nortrachelogenin (I), and a known compound, daphnoretin were isolated from Wikstroemia indica C.A. Meyer (Thymelaeaceae).
    CONCLUSIONS:
    The structure of (+)-Nortrachelogenin was established as 8(R)8'-4,4',8'-trihydroxy-3,3'-dimethoxylignan-olid, (9,9') on the basis of spectroscopic evidence and comparison with its enantiomer, (-)-nortrachelogenin. +-nortrachelogenin(I) showed effects on the central nervous system producing depression in rabbits.
    Planta Med. 2000 Aug;66(6):564-7.
    Antifungal, antimitotic and anti-HIV-1 agents from the roots of Wikstroemia indica.[Pubmed: 10985087]

    METHODS AND RESULTS:
    With guidance of Pyricularia oryzae bioassay, daphnoretin (1), (+)-Nortrachelogenin (2), genkwanol A (3), wikstrol A (4), wikstrol B (5) and daphnodorin B (6) were isolated from the roots of Wikstroemia indica. Compounds 1-6 induced morphological deformation of P. oryzae mycelia with MMDC values of 68.4 +/- 1.3, 31.3 +/- 1.8, 45.8 +/- 0.5, 70.1 +/- 2.4, 52.3 +/- 0.9 and 73.7 +/- 1.6 microM, respectively. Compounds 3-6 showed moderate activity against microtubule polymerization with IC50 values of 112 +/- 4, 131 +/- 3, 184 +/- 6 and 142 +/- 2 microM in vitro, respectively.
    CONCLUSIONS:
    Compounds 2, 3, 5 and 6 were moderately active against HIV-1 in vitro. The findings of bioactivity of 1-6 support the antifungus, antimitosis and anti-HIV-1 uses for W. indica roots.
    (+)-Nortrachelogenin Description
    Source: The roots of Wikstroemia indica.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6711 mL 13.3554 mL 26.7108 mL 53.4217 mL 66.7771 mL
    5 mM 0.5342 mL 2.6711 mL 5.3422 mL 10.6843 mL 13.3554 mL
    10 mM 0.2671 mL 1.3355 mL 2.6711 mL 5.3422 mL 6.6777 mL
    50 mM 0.0534 mL 0.2671 mL 0.5342 mL 1.0684 mL 1.3355 mL
    100 mM 0.0267 mL 0.1336 mL 0.2671 mL 0.5342 mL 0.6678 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.