Science | Nature | Cell | View More
Natural Products
Oleficin
Oleficin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Oleficin
Price:
CAS No.: 12764-54-4
Catalog No.: CFN00128
Molecular Formula: C34H47NO9
Molecular Weight: 613.74 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Red powder
Source: From Streptomyces parvulus.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Warszawski Uniwersytet Medyczny (Poland)
  • Weizmann Institute of Science (Israel)
  • Centralised Purchases Unit (CPU... (India)
  • National Research Council of Ca... (Canada)
  • Leibniz-Institut für Pflanzenb... (Germany)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Sapienza University of Rome (Italy)
  • University of Hawaii Cancer Center (USA)
  • University of Melbourne (Australia)
  • Mahidol University (Thailand)
  • National Hellenic Research Foun... (Greece)
  • More...
Package
Featured Products
Nordihydrocapsaicin

Catalog No: CFN90241
CAS No: 28789-35-7
Price: $268/20mg
Obtusifolin

Catalog No: CFN90394
CAS No: 477-85-0
Price: $268/20mg
Chicoric acid

Catalog No: CFN99725
CAS No: 6537-80-0
Price: $70/20mg
Chebulinic acid

Catalog No: CFN92296
CAS No: 18942-26-2
Price: $138/20mg
3-Hydroxy-4-methoxycinnamic acid

Catalog No: CFN99135
CAS No: 537-73-5
Price: $30/20mg
Taraxasterol acetate

Catalog No: CFN97104
CAS No: 6426-43-3
Price: $/mg
Costunolide

Catalog No: CFN98928
CAS No: 553-21-9
Price: $40/20mg
Silychristin

Catalog No: CFN90243
CAS No: 33889-69-9
Price: $218/20mg
Acanthoside B

Catalog No: CFN97220
CAS No: 7374-79-0
Price: $268/20mg
Alisol A 24-acetate

Catalog No: CFN90198
CAS No: 18674-16-3
Price: $118/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Oleficin, a polyene antibiotic, it is active against Grampositive bacteria and has no effect upon the growth of fungi and yeasts.Oleficin has effects on mitochondrial functions can be explained on the basis of an increase of the inner membrane permeability as the consequence of the depletion of Mg2+ from mitochondria caused by the antibiotic. It could as an ionophore of Mg2+ in isolated rat liver mitochondria, preferentially inhibit growth of the yeast Saccharomyces cerevisiae on non-fermentable substrates.
Targets: Sodium Channel | ATPase | Potassium Channel | Antifection
In vitro:
Biochim Biophys Acta. 1982 Dec 30;721(4):349-56.
Ionophores and intact cells. II. Oleficin acts on mitochondria and induces disintegration of the mitochondrial genome in yeast Saccharomyces cerevisiae.[Pubmed: 6818995]

METHODS AND RESULTS:
The non-macrolid polyene antibiotic Oleficin, which has been shown to function as an ionophore of Mg2+ in isolated rat liver mitochondria, preferentially inhibited growth of the yeast Saccharomyces cerevisiae on non-fermentable substrates. It uncoupled and inhibited respiration of intact cells and converted both growing and resting cells into respiration-deficient mutants. The mutants arose as a result of fragmentation of the mitochondrial genome. Another antibiotic known to be an ionophore of divalent cations, A23187, also selectively inhibited growth of the yeast on non-fermentable substrates, but did not produce the respiration-deficient mutants, neither antibiotic inhibited the energy-dependent uptake of divalent cations by yeast cells nor opened the plasma membrane for these cations.
CONCLUSIONS:
The results indicate that in Saccharomyces cerevisiae both Oleficin and A23187 preferentially affected the mitochondrial membrane without acting as ionophores in the plasma membrane.
J Antibiot (Tokyo). 1971 May;24(5):277-82.
Antibiotics produced by Streptomyces. 8. A new polyenic antibiotic, oleficin, exhibiting antibacterial activity[Reference: WebLink]
A new polyenic antibiotic has been isolated from a strain A-461, related to Streptomyces parvulus which is described in this paper.
METHODS AND RESULTS:
Oleficin was obtained as a dark red powder by methanolic extraction of the filtered mycelium, followed by evaporation of the solvent and re-extraction into ethyl acetate, evaporation, precipitation with petroleum ether and chromatography on alumina. Its ultraviolet and visible spectra suggest the possible presence in its molecule of two chromophores, one of which is a polyene-like.
CONCLUSIONS:
It is active against Grampositive bacteria and has no effect upon the growth of fungi and yeasts.
Oleficin Description
Source: From Streptomyces parvulus.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Cuneataside C

Catalog No: CFN95368
CAS No: 871720-16-0
Price: $318/10mg
Oxytroflavoside B

Catalog No: CFN95490
CAS No: 1391144-81-2
Price: $318/10mg
1-(3',5'-dimethoxy)phenyl-2-[4''-O...

Catalog No: CFN95285
CAS No: 1338076-61-1
Price: $413/5mg
Isoedultin

Catalog No: CFN95273
CAS No: 43043-08-9
Price: $318/5mg
Notoginsenoside L13

Catalog No: CFN95332
CAS No: 2485859-56-9
Price: $318/5mg
Aegineoside

Catalog No: CFN95270
CAS No: 752209-48-6
Price: $413/5mg
Fuzitine

Catalog No: CFN95337
CAS No: 142287-96-5
Price: $318/5mg
1-Phenylethyl beta-D-glucoside

Catalog No: CFN95574
CAS No: 93199-03-2
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.6294 mL 8.1468 mL 16.2935 mL 32.5871 mL 40.7339 mL
5 mM 0.3259 mL 1.6294 mL 3.2587 mL 6.5174 mL 8.1468 mL
10 mM 0.1629 mL 0.8147 mL 1.6294 mL 3.2587 mL 4.0734 mL
50 mM 0.0326 mL 0.1629 mL 0.3259 mL 0.6517 mL 0.8147 mL
100 mM 0.0163 mL 0.0815 mL 0.1629 mL 0.3259 mL 0.4073 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
J Antibiot (Tokyo). 1980 May;33(5):494-500.
Interaction of oleficin with the inner membrane of rat liver mitochondria.[Pubmed: 6448831]
The effects of Oleficin, a polyene antibiotic of the nonmacrolide type, on isolated rat liver mitochondria were studied. Oleficin at a concentration of about 10 nmoles/mg protein increases both the rate of state 4 respiration and the "basal" ATPase activity of mitochondria. In contrast to this it inhibits the rate of both state 3 and uncoupled respiration and the DNP-stimulated ATPase activity.
METHODS AND RESULTS:
These inhibitions can be prevented by low concentrations (2 approximately 5 mM) of magnesium ions. Oleficin induces a high amplitude swelling of non-respiring mitochondria in the isoosmotic nitrate and chloride solutions of K+, Na+, Tris+, Tea+ or Mg2+. In contrast to that it does not induce swelling of mitochondria treated with ruthenium red in isoosmotic calcium acetate. Indirect evidence suggests that Oleficin increases also the proton permeability of the inner membrane. The swelling observed in the isoosmotic solutions of monovalent cations can be prevented by low concentration (2 approximately 5 mM) of Mg2+. In the presence of the antibiotic Mg2+ and Ca2+ but not K+ and Na+, are transferred from an aqueous phase into a butanol-toluene bulk phase. Oleficin depletes Mg2+ and Ca2+ from mitochondria in a concentration dependent manner. Complete depletion of Mg2+ occurs only in the presence of EDTA, while that of Ca2+ does not need the chelator.
CONCLUSIONS:
It is concluded that the effects of Oleficin on mitochondrial functions can be explained on the basis of an increase of the inner membrane permeability as the consequence of the depletion of Mg2+ from mitochondria caused by the antibiotic.
Nordihydrocapsaicin

Catalog No: CFN90241
CAS No: 28789-35-7
Price: $268/20mg
Obtusifolin

Catalog No: CFN90394
CAS No: 477-85-0
Price: $268/20mg
Chicoric acid

Catalog No: CFN99725
CAS No: 6537-80-0
Price: $70/20mg
Chebulinic acid

Catalog No: CFN92296
CAS No: 18942-26-2
Price: $138/20mg
3-Hydroxy-4-methoxycinnamic acid

Catalog No: CFN99135
CAS No: 537-73-5
Price: $30/20mg
Taraxasterol acetate

Catalog No: CFN97104
CAS No: 6426-43-3
Price: $/mg
Costunolide

Catalog No: CFN98928
CAS No: 553-21-9
Price: $40/20mg
Silychristin

Catalog No: CFN90243
CAS No: 33889-69-9
Price: $218/20mg
Acanthoside B

Catalog No: CFN97220
CAS No: 7374-79-0
Price: $268/20mg
Alisol A 24-acetate

Catalog No: CFN90198
CAS No: 18674-16-3
Price: $118/20mg
Tags: buy Oleficin | Oleficin supplier | purchase Oleficin | Oleficin cost | Oleficin manufacturer | order Oleficin | Oleficin distributor