ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
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More articles cited ChemFaces products.
Molecules.2013 Nov 14;18(11):14105-21. Korean Herb. Med. Inf. 2016;4(1):35-42BMC Complement Altern Med.2014 Sep 23;14:352.Journal of Life Science2017.2;ARPN Journal of Eng.& Applied Sci.4, Feb. 2016
Food Analytical Methods07 April 2017SBRAS2016(12)Pharm Biol. 2017 Dec;PLoS One. 2015 May 15.Plant J. 2017 May;
Planta Med 2016 Apr 28.BMC Complement Altern Med.2017 Aug 9;Neuropharmacology.2018 Mar 15;Int J Oncol. 2016 Oct;49(4)
Our products had been exported to the following research institutions and universities, And still growing.
University of Bordeaux (France)Almansora University (Egypt)Martin Luther University of Hall... (Germany)Universidad de La Salle (Mexico)
Kazusa DNA Research Institute (Japan)Sanford Burnham Prebys Medical D... (USA)Johannes Gutenberg University Ma... (Germany)Medical University of South Caro... (USA)
Instituto de Investigaciones Agr... (Chile)Tohoku University (Japan)Cancer Research Initatives Found... (Malaysia)
||The herbs of Lepidium sativum
|Biological Activity or Inhibitors:
|| 1. Oleacein is a strong Angiotensin Converting Enzyme (ACE)-inhibitor (IC50 = 26 uM).
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Oleoside References Information
Phytomedicine, 1996, 2(4):319-25.
|Isolation of an angiotensin converting enzyme (ACE) inhibitor from Olea europaea and Olea lancea.[Pubmed: 23194770 ]|
|The aqueous extract of the leaves of Olea europaea and Olea lancea both inhibited Angiotensin Converting Enzyme (ACE) in vitro. A bioassay-directed fractionation resulted in the isolation of a strong ACE-inhibitor namely the secoiridoid 2-(3,4-dihydroxyphenyl)ethyl 4-formyl-3-(2-oxoethyl)-4 E-hexenoate (oleacein) (IC(50) = 26 μM). Five secoiridoid glycosides (oleuropein, ligstroside, excelcioside, Oleoside 11-methyl ester, Oleoside) isolated from Oleaceous plants showed no significant ACE-inhibition whereas, after enzymatic hydrolysis, the ACE-inhibition at 0.33 mg/ml was between 64% to 95%. Secoiridoids have not been described previously in the literature as inhibitors of ACE. Oleacein showed a low toxicity in the brine shrimp (Artemia satina) lethality test (LC(50) (24 h) = 969 ppm).