|Source:||The heartwood of Caesalpinia sappan L.|
|Biological Activity or Inhibitors:||1. Ombuin inhibits some macrophage functions involved in the inflammatory process.
2. Ombuin significantly and dose dependently inhibits lipopolysaccharide (LPS) and interferon (IFN)-gamma induced nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12].
|Solvent:||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||3.0276 mL||15.1378 mL||30.2755 mL||60.551 mL||75.6888 mL|
|5 mM||0.6055 mL||3.0276 mL||6.0551 mL||12.1102 mL||15.1378 mL|
|10 mM||0.3028 mL||1.5138 mL||3.0276 mL||6.0551 mL||7.5689 mL|
|50 mM||0.0606 mL||0.3028 mL||0.6055 mL||1.211 mL||1.5138 mL|
|100 mM||0.0303 mL||0.1514 mL||0.3028 mL||0.6055 mL||0.7569 mL|
Phytother Res. 2008 Jul;22(7):957-62.
|Antiinflammatory activities of flavonoids and a triterpene caffeate isolated from Bauhinia variegata.[Pubmed: 18384188]|
|In the continuing search for novel antiinflammatory agents, six flavonoids, namely kaempferol (1), Ombuin (2), kaempferol 7,4'-dimethyl ether 3-O-beta-D-glucopyranoside (3), kaempferol 3-O-beta-D-glucopyranoside (4), isorhamnetin 3-O-beta-D-glucopyranoside (5) and hesperidin (6), together with one triterpene caffeate, 3beta-trans-(3,4-dihydroxycinnamoyloxy)olean-12-en-28-oic acid (7) were isolated from the non-woody aerial parts of Bauhinia variegata. Compounds 1-7 were evaluated as inhibitors of some macrophage functions involved in the inflammatory process. These seven compounds significantly and dose dependently inhibited lipopolysaccharide (LPS) and interferon (IFN)-gamma induced nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12]. The concentration causing a 50% inhibition (IC50) of NO, TNF-alpha and IL-12 production by compounds 1, 2 and 7 was approximately 30, 50 and 10 microM, respectively.|
Planta Med. 1998 Jun;64(5):464-6.
|Licochalcone A: an inducer of cell differentiation and cytotoxic agent from Pogostemon cablin.[Pubmed: 9690352]|
|Licochalcone A (1), Ombuin (2), and 5,7-dihydroxy-3',4'-dimethoxyflavanone (3) were isolated from the aerial parts of Pogostemon cablin by cytotoxicity-guided fractionation. Compound 1 showed in vitro cytotoxicity and Pl-PLC gamma 1 inhibition activity. Treatment of promyelocytic leukemia cells (HL-60) with compound 1 induced terminal differentiation with the generation of monocyte using nonspecific acid esterase assay.|