Onitin | CAS:53823-02-2 | Manufacturer ChemFaces

Onitin

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Description:

Onitin shows super-oxide and DPPH free radical scavenging effects.It also exhibits hepatoprotective activity on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells.

In vitro:

J Ethnopharmacol. 2004 Dec;95(2-3):421-4.

Hepatoprotective and free radical scavenging activities of phenolic petrosins and flavonoids isolated from Equisetum arvense.[Pubmed: 15507369 ]

METHODS AND RESULTS:
Hepatoprotective activity-guided fractionation of the MeOH extract of Equisetum arvense L. (Equisetaceae) resulted in the isolation of two phenolic petrosins, Onitin (1) and Onitin-9-O-glucoside (2), along with four flavonoids, apigenin (3), luteolin (4), kaempferol-3-O-glucoside (5), and quercetin-3-O-glucoside (6). Among these, Onitin and luteolin exhibited hepatoprotective activities on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells, displaying EC(50) values of 85.8 +/ -9.3 microM and 20.2 +/- 1.4 microM, respectively. Silybin, used as a positive control, showed the EC(50) value of 69.0 +/- 3.3 microM. Onitin and luteolin also showed superoxide scavenging effects (IC(50) = 35.3 +/- 0.2 microM and 5.9 +/- 0.3 microM, respectively) and DPPH free radical scavenging effect (IC(50) of 35.8 +/- 0.4 microM and 22.7 +/- 2.8 microM, respectively).
CONCLUSIONS:
These results support the use of this plant for the treatment of hepatitis in oriental traditional medicine.

Onitin Description

Source:	The herbs of Onychium japonicum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Onitin
Price:
CAS No.:	53823-02-2
Catalog No.:	CFN98898
Molecular Formula:	C₁₅H₂₀O₃
Molecular Weight:	248.3 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	The herbs of Onychium japonicum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Hepatoprotective Compound Library Anti-spasmodic Compound Library Smooth muscle relaxing activity Compound Library Sesquiterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.0274 mL	20.1369 mL	40.2739 mL	80.5477 mL	100.6847 mL
5 mM	0.8055 mL	4.0274 mL	8.0548 mL	16.1095 mL	20.1369 mL
10 mM	0.4027 mL	2.0137 mL	4.0274 mL	8.0548 mL	10.0685 mL
50 mM	0.0805 mL	0.4027 mL	0.8055 mL	1.611 mL	2.0137 mL
100 mM	0.0403 mL	0.2014 mL	0.4027 mL	0.8055 mL	1.0068 mL

CFN89000	Norpterosin B glucoside	1226785-88-1	366.41	C₁₉H₂₆O₇
CFN96798	Pterosin B	34175-96-7	218.29	C₁₄H₁₈O₂
CFN96609	trans-Norpterosin C	64890-70-6	220.27	C₁₃H₁₆O₃
CFN96802	Pterosin C	35938-43-3	234.29	C₁₄H₁₈O₃
CFN80185	Pterosin G	35964-50-2	234.12	C₁₄H₁₈O₃
CFN97251	Onitin 2'-O-glucoside	76947-60-9	410.5	C₂₁H₃₀O₈
CFN98899	Onitisin	53823-03-3	264.3	C₁₅H₂₀O₄
CFN97066	Onitisin 2'-O-glucoside	62043-53-2	426.5	C₂₁H₃₀O₉
CFN98442	Pterosin Z	34169-69-2	232.3	C₁₅H₂₀O₂
CFN80051	Pterosin A	35910-16-8	248.14	C₁₅H₂₀O₃