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    Oplodiol
    Information
    CAS No. 13902-62-0 Price
    Catalog No.CFN99440Purity>=98%
    Molecular Weight238.4 Type of CompoundSesquiterpenoids
    FormulaC15H26O2Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Our products had been exported to the following research institutions and universities, And still growing.
  • Worcester Polytechnic Institute (USA)
  • Florida A&M University (USA)
  • Weizmann Institute of Science (Israel)
  • Universidad de Buenos Aires (Argentina)
  • Universidade Católica Portuguesa (Portugal)
  • The University of Newcastle (Australia)
  • Johannes Gutenberg University Ma... (Germany)
  • Cornell University (USA)
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  • Korea Food Research Institute(KF... (Korea)
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  • Package
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    Biological Activity
    Description: 1. Oplodiol exhibits noteworthy anti-plasmodial activity against Plasmodium falciparum strains.
    2. Oplodiol has a stimulative effect on significantly proliferation and differentiation of culture osteoblasts.
    3. Oplodiol shows moderate cytotoxic effects on the human lung adenocarcinoma A549 with IC50 values at 25.5 ug/mL.
    Targets: Influenza virus
    Oplodiol Description
    Source: The branch of Platycladus orientalis
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi: 10.1016/j.phymed.2017.12.030.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.1946 mL 20.9732 mL 41.9463 mL 83.8926 mL 104.8658 mL
    5 mM 0.8389 mL 4.1946 mL 8.3893 mL 16.7785 mL 20.9732 mL
    10 mM 0.4195 mL 2.0973 mL 4.1946 mL 8.3893 mL 10.4866 mL
    50 mM 0.0839 mL 0.4195 mL 0.8389 mL 1.6779 mL 2.0973 mL
    100 mM 0.0419 mL 0.2097 mL 0.4195 mL 0.8389 mL 1.0487 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Oplodiol References Information
    Citation [1]

    Nat Prod Res. 2014;28(20):1669-73.

    A new sesquiterpenoid from the rhizomes of Homalomena occulta.[Pubmed: 25104218]
    Chemical constituents of EtOAc extract from the rhizomes of traditional Chinese medicine Qian-nian-jian (Homalomena occulta) have been studied, a new sesquiterpenoid, named euadesma-4-ene-1β,15-diol (1), and four related known compounds, polydactin B (2), Oplodiol (3), 1β,4β,7α-trihydroxyeudesmane (4), and (-)1β,4β,6α-trihydroxy-eudesmane (5), were isolated. Their structures were elucidated using spectroscopic methods including 1D and 2D NMR techniques and mass spectrometry. All the isolates were tested against the human lung adenocarcinoma A549 using MTT assay method. Oplodiol (3) and (-)1β,4β,6α-trihydroxy-eudesmane (5) were found to show moderate cytotoxic effects on A549 with IC50 values at 25.5 and 15.0 μg/mL, respectively.
    Citation [2]

    J Asian Nat Prod Res. 2015 May 12:1-9.

    Sesquiterpenes from the roots of Illicium oligandrum.[Pubmed: 25966312]
    Two new sesquiterpenes, oligandrin (1) and oligandric acid (2), together with three analogues, tashironin A (3), tashironin (4), and Oplodiol (5), were isolated from the roots of Illicium oligandrum. The structures of new compounds were determined based on 1D and 2D NMR experiments and X-ray diffraction. Compound 1 represents a presumed biosynthetic precursor of seco-prezizaane sesquiterpenes which consists of a novel 6/6/5 tricarbocyclic skeleton. Compound 2 is the first example of chamipinene-type sesquiterpene possessing a 6/4/6 tricyclic system from the genus Illicium. Compounds 1-5 were evaluated in vitro for their activity against coxsackie virus B3 (CVB3), influenza virus A/Hanfang/359/95 (H3N2), and influenza virus A/FM/1/47 (H1N1). Compound 1 showed selective antiviral activity against CVB3 with IC50 value of 11.11 μM.
    Citation [3]

    Phytochemistry, 1999, 52(6):1095-9.

    Anti-plasmodial sesquiterpenoids from the African Reneilmia cincinnata.[Pubmed: 10643672]
    A new isodaucane sesquiterpenoid, 6,7,10-trihydoxyisodaucane, was isolated from the fruits of Reneilmia cincinnata, together with the known sesquiterpenoids Oplodiol, oplopanone, 5E,10(14)-germacradien-1 beta, 4 beta-diol, 1(10)E,5E-germacradien-4 alpha-ol and eudesman-1,4,7-triol. A large amount of 5-hydroxy-3,7,4'-trimethoxyflavone was also isolated. Their structures were established by NMR techniques using 1D and 2D experiments. Three of the known sesquirernenoids exhibited noteworthy anti-plasmodial activity against Plasmodium falciparum strains.
    Citation [4]

    Phytochemistry. 2008 Sep;69(12):2367-73.

    Sesquiterpenoids from Homalomena occulta affect osteoblast proliferation, differentiation and mineralization in vitro.[Pubmed: 18649899 ]
    Chemical investigation of rhizomes of Homalomena occulta (Lours) resulted in isolation and identification of two sesquiterpenoids (6,7), and one daucane ester 8, together with five known sesquiterpenoids, Oplodiol, oplopanone, homalomenol C, bullatantriol, and 1beta,4beta,7alpha-trihydroxyeudesmane. Their structures were elucidated using 1D and 2D NMR spectroscopic and X-ray analyses. The chloroform extract of this plant and compounds 1-7 were tested in vitro for their activities in stimulating osteoblast (OB) proliferation, differentiation and mineralization. Compounds 1-4 had a stimulative effect on significantly proliferation and differentiation of culture osteoblasts, while the chloroform extract and 1 significantly stimulated mineralization of cultured osteoblasts in vitro