Science | Nature | Cell | View More
Natural Products
Oxypeucedanin hydrate
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Oxypeucedanin hydrate
Price: $80 / 20mg
CAS No.: 2643-85-8
Catalog No.: CFN90557
Molecular Formula: C16H16O6
Molecular Weight: 304.29 g/mol
Purity: >=98%
Type of Compound: Coumarins
Physical Desc.: Cryst.
Source: The roots of Angelica dahurica.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $21.5 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Lund University (Sweden)
  • National Cancer Institute (USA)
  • Kitasato University (Japan)
  • Wageningen University (Netherlands)
  • Research Unit Molecular Epigene... (Germany)
  • University of Liège (Belgium)
  • The Vancouver Prostate Centre (... (Canada)
  • Gyeongsang National University (Korea)
  • Chang Gung University (Taiwan)
  • Tokyo Woman's Christian University (Japan)
  • Leibniz-Institut für Pflanzenb... (Germany)
  • More...
Package
Featured Products
Muscone

Catalog No: CFN99518
CAS No: 541-91-3
Price: $30/20mg
Cinnamaldehyde

Catalog No: CFN99478
CAS No: 104-55-2
Price: $30/20mg
Quercetin 3,5,7,3,4-pentamethyl et...

Catalog No: CFN70262
CAS No: 1247-97-8
Price: $ / mg
Syringaresinol-di-O-glucoside

Catalog No: CFN90458
CAS No: 66791-77-3
Price: $138/20mg
Eurycomanone

Catalog No: CFN92008
CAS No: 84633-29-4
Price: $268/20mg
Ginsenoside Rg6

Catalog No: CFN90565
CAS No: 147419-93-0
Price: $268/5mg
8-Acetoxypinoresinol

Catalog No: CFN00449
CAS No: 81426-14-4
Price: $ / mg
trans-Caryophyllene

Catalog No: CFN90502
CAS No: 87-44-5
Price: $30/20mg
Dulcoside A

Catalog No: CFN92266
CAS No: 64432-06-0
Price: $ / mg
Sinigrin

Catalog No: CFN90453
CAS No: 3952-98-5
Price: $80/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Oxypeucedanin hydrate is an antimutagenic agent, it has antioxidant activity, and exhibits carbohydrate metabolizing enzymes inhibitory effect.
Targets: p21 | EGFR | Estrogen receptor | Caspase | Progestogen receptor
In vitro:
J Chromatogr B Biomed Sci Appl. 2001 Apr 5;753(2):309-14.
Simultaneous determination of byak-angelicin and oxypeucedanin hydrate in rat plasma by column-switching high-performance liquid chromatography with ultraviolet detection.[Pubmed: 11334345]

METHODS AND RESULTS:
A simple and sensitive column-switching HPLC method was developed for the simultaneous determination of two furocoumarin compounds, byak-angelicin and Oxypeucedanin hydrate, which are the main components of hot water extract of Angelica dahurica root (AE), in rat plasma. Plasma sample was simply deproteinated with perchloric acid. After centrifugation, the supernatant was injected into a column-switching HPLC system consisting of a clean-up column (Symmetry Shield RP 8, 20x3.9 mm I.D.) and analytical column (Symmetry C18, 75x4.6 mm I.D.) which were connected with a six-port switching valve. The flow-rate of the mobile phase (acetonitrile-water, 20:80) was maintained at 1 ml/min. Detection was carried out at wavelength 260 nm with a UV detector. The column temperature was maintained at 40 degrees C. The calibration curves of byak-angelicin and Oxypeucedanin hydrate were linear over the ranges 19.6 to 980 ng/ml (r2>0.997). The accuracy of these analytes was less than 4.4%. The intra- and inter-day relative standard deviations of byak-angelicin and Oxypeucedanin hydrate were within 12.0% and 12.7%, respectively.
CONCLUSIONS:
The present method was applied for the analysis of plasma concentration from rats after administration of AE.
Pharm Biol . 2018 Dec;56(1):658-664.
Antiproliferative and cytotoxic activities of furocoumarins of Ducrosia anethifolia[Pubmed: 31070540]
Abstract Context: Phytochemical and pharmacological data on Ducrosia anethifolia (DC.) Boiss. (Apiaceae), an Iranian medicinal plant, are scarce; however, furocoumarins are characteristic compounds of D. anethifolia. Objective: Our experiments identify the secondary metabolites of D. anethifolia and assess their antitumor and anti-multidrug resistance activities. Materials and methods: Pure compounds were isolated from the extract of aerial parts of the plant by chromatographic methods. Bioactivities were tested on multidrug resistant and sensitive mouse T-lymphoma cell lines. The inhibition of the cancer MDR efflux pump ABCB1 was evaluated by flow cytometry (at 2 and 20 μM). A checkerboard microplate method was applied to study the interactions of furocoumarins and doxorubicin. Toxicity was studied using normal murine NIH/3T3 fibroblasts. Results: Thirteen pure compounds were isolated, nine furocoumarins namely, pabulenol (1), (+)-Oxypeucedanin hydrate (2), oxypeucedanin (3), oxypeucedanin methanolate (4), (-)-Oxypeucedanin hydrate (5), imperatorin (6), isogospherol (7), heraclenin (8), heraclenol (9), along with vanillic aldehyde (10), harmine (11), 3-hydroxy-α-ionone (12) and 2-C-methyl-erythrytol (13). Oxypeucedanin showed the highest in vitro antiproliferative and cytotoxic activity against parent (IC50 = 25.98 ± 1.27, 40.33 ± 0.63 μM) and multidrug resistant cells (IC50 = 28.89 ± 0.73, 66.68 ± 0.00 μM), respectively, and exhibited slight toxicity on normal murine fibroblasts (IC50 = 57.18 ± 3.91 μM). Discussion and conclusions: Compounds 2, 3, 5, 7, 10-13 were identified for the first time from the Ducrosia genus. Here, we report a comprehensive in vitro assessment of the antitumor activities of D. anethifolia furocoumarins. Oxypeucedanin is a promising compound for further investigations for its anticancer effects. Keywords: ABCB1; Multidrug resistance; PAR; aviprin; prangol; checkerboard assay.
In vivo:
Biomed Res Int. 2014;2014:480545.
Preliminary in vitro and in vivo evaluation of antidiabetic activity of Ducrosia anethifolia Boiss. and its linear furanocoumarins.[Pubmed: 24800231]
Ducrosia anethifolia is used as flavoring additive. There have been little detailed phytochemical reports on this genus and the antidiabetic activity of this plant is not yet evaluated.
METHODS AND RESULTS:
Structure of compounds was deduced by spectroscopic analyses. Preliminary in vitro evaluation of the antidiabetic activity of crude extract and its furanocoumarins was carried out ( α -amylase, α -glucosidase, and β -galactosidase). The in vivo activity was investigated by measuring some oxidative stress markers. Biomarkers of liver injury and kidney were also determined. Eight linear furanocoumarins, psoralen, 5-methoxypsoralen, 8-methoxypsoralen, imperatorin, isooxypeucedanin, pabulenol, oxypeucedanin methanolate, Oxypeucedanin hydrate, and 3-O-glucopyranosyl- β -sitosterol, were isolated. All compounds were reported for the first time from the genus Ducrosia except pabulenol. The blood glucose level, liver function enzymes, total protein, lipid, and cholesterol levels were significantly normalized by extract treatment. The antioxidant markers, glucolytic, and gluconeogenic enzymes were significantly ameliorated and the elevated level of kidney biomarkers in the diabetic groups was restored. The compounds showed inhibitory activity in a concentration dependant manner. Imperatorin and 5-methoxypsoralen showed the most potent inhibiting power.
CONCLUSIONS:
D. anethifolia extract showed hypoglycemic, hypolipidemic, and antioxidant effect as well as ameliorating kidney function. This extract and some linear furanocoumarins exhibited carbohydrate metabolizing enzymes inhibitory effect.
Oxypeucedanin hydrate Description
Source: The roots of Angelica dahurica.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
3',8-Dihydroxyvestitol

Catalog No: CFN95384
CAS No: 122587-87-5
Price: $413/5mg
Tectoruside

Catalog No: CFN95051
CAS No: 38784-73-5
Price: $288/20mg
1-Methoxycarbonyl-beta-carboline-N...

Catalog No: CFN95023
CAS No: 74690-74-7
Price: $318/5mg
Notoginsenoside L13

Catalog No: CFN95332
CAS No: 2485859-56-9
Price: $318/5mg
2-Methoxy-1,4-naphthoquinone

Catalog No: CFN95269
CAS No: 2348-82-5
Price: $70/20mg
Physalin O

Catalog No: CFN95097
CAS No: 120849-18-5
Price: $413/5mg
Angelol M

Catalog No: CFN95060
CAS No: 1092952-64-1
Price: $288/5mg
3''-O-Caffeoylhesperidin

Catalog No: CFN95564
CAS No: N/A
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2863 mL 16.4317 mL 32.8634 mL 65.7268 mL 82.1585 mL
5 mM 0.6573 mL 3.2863 mL 6.5727 mL 13.1454 mL 16.4317 mL
10 mM 0.3286 mL 1.6432 mL 3.2863 mL 6.5727 mL 8.2158 mL
50 mM 0.0657 mL 0.3286 mL 0.6573 mL 1.3145 mL 1.6432 mL
100 mM 0.0329 mL 0.1643 mL 0.3286 mL 0.6573 mL 0.8216 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Muscone

Catalog No: CFN99518
CAS No: 541-91-3
Price: $30/20mg
Cinnamaldehyde

Catalog No: CFN99478
CAS No: 104-55-2
Price: $30/20mg
Quercetin 3,5,7,3,4-pentamethyl et...

Catalog No: CFN70262
CAS No: 1247-97-8
Price: $ / mg
Syringaresinol-di-O-glucoside

Catalog No: CFN90458
CAS No: 66791-77-3
Price: $138/20mg
Eurycomanone

Catalog No: CFN92008
CAS No: 84633-29-4
Price: $268/20mg
Ginsenoside Rg6

Catalog No: CFN90565
CAS No: 147419-93-0
Price: $268/5mg
8-Acetoxypinoresinol

Catalog No: CFN00449
CAS No: 81426-14-4
Price: $ / mg
trans-Caryophyllene

Catalog No: CFN90502
CAS No: 87-44-5
Price: $30/20mg
Dulcoside A

Catalog No: CFN92266
CAS No: 64432-06-0
Price: $ / mg
Sinigrin

Catalog No: CFN90453
CAS No: 3952-98-5
Price: $80/20mg
Tags: buy Oxypeucedanin hydrate | Oxypeucedanin hydrate supplier | purchase Oxypeucedanin hydrate | Oxypeucedanin hydrate cost | Oxypeucedanin hydrate manufacturer | order Oxypeucedanin hydrate | Oxypeucedanin hydrate distributor