|Source:||The root barks of Morus alba L.|
|Biological Activity or Inhibitors:||1. Oxyresveratrol-3'-O-beta-D-glucopyranoside shows better tyrosinase inhibitory activities than kojic acid.
2. Oxyresveratrol-3-O-glucoside and oxyresveratrol may be potential candidates as skin-whitening agents without posing any serious side effects.
|Solvent:||Pyridine, Methanol, Ethanol, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||2.4606 mL||12.3031 mL||24.6063 mL||49.2126 mL||61.5157 mL|
|5 mM||0.4921 mL||2.4606 mL||4.9213 mL||9.8425 mL||12.3031 mL|
|10 mM||0.2461 mL||1.2303 mL||2.4606 mL||4.9213 mL||6.1516 mL|
|50 mM||0.0492 mL||0.2461 mL||0.4921 mL||0.9843 mL||1.2303 mL|
|100 mM||0.0246 mL||0.123 mL||0.2461 mL||0.4921 mL||0.6152 mL|
J. Agric. Food Chem.,2010,12;58(9):5368-73.
|Tyrosinase inhibitory constituents from the roots of Morus nigra: a structure-activity relationship study.[Pubmed: 20297841]|
|The phytochemical profiles of Morus nigra roots and twigs were compared by HPLC with those of the old and young twigs of Morus alba which are known to contain oxyresveratrol and mulberroside A as major components. It was found that M. nigra root extract contains some unknown natural products with potential tyrosinase inhibitory activity. The extract (95% ethanol) of the roots of M. nigra was further investigated in this study. One new compound, 5'-geranyl-5,7,2',4'-tetrahydroxyflavone, and twenty-eight known phenolic compounds were isolated. Their structures were identified by mass spectrometry and NMR spectroscopy. Nine compounds, 5'-geranyl-5,7,2',4'-tetrahydroxyflavone, steppogenin-7-O-beta-D-glucoside, 2,4,2',4'-tetrahydroxychalcone, moracin N, kuwanon H, mulberrofuran G, morachalcone A, Oxyresveratrol 3'-O-beta-D-glucopyranoside and oxyresveratrol-2-O-beta-D-glucopyranoside, showed better tyrosinase inhibitory activities than kojic acid. It was noteworthy that the IC(50) values of 2,4,2',4'-tetrahydroxychalcone and morachalcone A were 757-fold and 328-fold lower than that of kojic acid, respectively, suggesting a great potential for their development as effective natural tyrosinase inhibitors.|