(-)-beta-Peltatin | CAS:518-29-6 | Manufacturer ChemFaces

(-)-beta-Peltatin

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Description:

(-)-beta-Peltatin has antimitotic, and antineoplastic activities.

In vitro:

Pesticide Biochemistry and Physiology, 2002, 72(1):45-54.

Aryltetralin Lignans Inhibit Plant Growth by Affecting the Formation of Mitotic Microtubular Organizing Centers.[Reference: WebLink]

METHODS AND RESULTS:
The aryltetralin lignans podophyllotoxin, α-peltatin, and β-peltatin（(-)-beta-Peltatin ）, their respective O-β-d-glucosides, and the semisynthetic derivative etoposide were tested for phytotoxicity. The aglycones were more potent inhibitors than their respective glucosides, and podophyllotoxin was the most active natural lignan tested. These compounds were more active against rye (Lolium multiflorum L.) and onion (Allium cepa L.) than lettuce (Lactuca sativa L.). The semisynthetic lignan etoposide was more active than any of the natural analogues and was phytotoxic to both monocotyledonous and dicotyledonous species. Inhibition of root growth was the main developmental response observed on plants tested with the lignans. At the cellular level, podophyllotoxin and etoposide caused similar symptoms in actively dividing meristematic cells of onion root tips. All phases of mitosis were inhibited by nearly 50%, relative to the controls. Both compounds also induced abnormal star anaphase chromosomal configurations.
CONCLUSIONS:
While the precise molecular mechanism of action of these compounds remains to be identified in plants, a primary effect is the alteration of the formation of the spindle microtubular organization centers, resulting in the formation of multiple spindle poles and an asymmetrical convergence of the chromosomes.

(-)-beta-Peltatin Description

Source:	The herbs of Podophyllum peltatum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	(-)-beta-Peltatin
Price:
CAS No.:	518-29-6
Catalog No.:	CFN92699
Molecular Formula:	C₂₂H₂₂O₈
Molecular Weight:	414.4 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Powder
Source:	The herbs of Podophyllum peltatum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Hepatoprotective Compound Library Antiviral Compound Library Lignans Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.4131 mL	12.0656 mL	24.1313 mL	48.2625 mL	60.3282 mL
5 mM	0.4826 mL	2.4131 mL	4.8263 mL	9.6525 mL	12.0656 mL
10 mM	0.2413 mL	1.2066 mL	2.4131 mL	4.8263 mL	6.0328 mL
50 mM	0.0483 mL	0.2413 mL	0.4826 mL	0.9653 mL	1.2066 mL
100 mM	0.0241 mL	0.1207 mL	0.2413 mL	0.4826 mL	0.6033 mL

CFN92623	Isoanthricin	17301-70-5	398.4	C₂₂H₂₂O₇
CFN70412	alpha-Peltatin	568-53-6	400.4	C₂₁H₂₀O₈
CFN92699	(-)-beta-Peltatin	518-29-6	414.4	C₂₂H₂₂O₈
CFN92700	(-)-beta-Peltatin-5-O-beta-D-glucopyranoside	11024-59-2	576.6	C₂₈H₃₂O₁₃
CFN99888	Deoxypodophyllotoxin	19186-35-7	398.4	C₂₂H₂₂O₇
CFN90483	4'-Demethylpodophyllotoxin	40505-27-9	400.37	C₂₁H₂₀O₈
CFN89061	Etoposide	33419-42-0	588.56	C₂₉H₃₂O₁₃
CFN91909	Podophyllotoxinone	477-49-6	412.39	C₂₂H₂₀O₈
CFN90443	Picropodophyllotoxin	17434-18-3	414.4	C₂₂H₂₂O₈
CFN99168	Podophyllotoxin	518-28-5	414.41	C₂₂H₂₂O₈