Perivine | CAS:2673-40-7 | Manufacturer ChemFaces

Perivine

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Perivine, vobasine, coronaridine and dichomine show hypotensive and muscle relaxant activity. Perivine may resolve the instability of the retinoblastoma-associated proteins (RbAp48) complex and thus be used in Alzheimer's disease therapy.

In vitro:

Biomed Res Int. 2014;2014:764946.

Lead discovery for Alzheimer's disease related target protein RbAp48 from traditional Chinese medicine.[Pubmed: 25165715]

Deficiency or loss of function of Retinoblastoma-associated proteins (RbAp48) is related with Alzheimer's disease (AD), and AD disease is associated with age-related memory loss. During normal function, RbAp48 forms a complex with the peptide FOG-1 (friend of GATA-1) and has a role in gene transcription, but an unstable complex may affect the function of RbAp48.
METHODS AND RESULTS:
This study utilizes the world's largest traditional Chinese medicine (TCM) database and virtual screening to provide potential compounds for RbAp48 binding. A molecular dynamics (MD) simulation was employed to understand the variations after protein-ligand interaction. FOG1 was found to exhibit low stability after RbAp48 binding; the peptide displayed significant movement from the initial docking position, a phenomenon which matched the docking results. The protein structure of the other TCM candidates was not variable during MD simulation and had a greater stable affinity for RbAp48 binding than FOG1.
CONCLUSIONS:
Our results reveal that the protein structure does not affect ligand binding, and the top three TCM candidates Bittersweet alkaloid II, Eicosandioic acid, and Perivine might resolve the instability of the RbAp48-FOG1 complex and thus be used in AD therapy.

In vivo:

J Ethnopharmacol. 1985 May;13(2):165-73.

Muscle relaxant activity and hypotensive activity of some Tabernaemontana alkaloids.[Pubmed: 4021514]

METHODS AND RESULTS:
Stemmadenine, the major alkaloid from the seeds of Tabernaemontana dichotoma, showed hypotensive activity and weak muscle relaxant activity. Perivine, vobasine, coronaridine and dichomine, some of the alkaloids found in the leaves, fruits and bark of T. dichotoma, also showed hypotensive and muscle relaxant activity.

Perivine Description

Source:	The herbs of Catharanthus roseus G. Don
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Perivine
Price:
CAS No.:	2673-40-7
Catalog No.:	CFN90441
Molecular Formula:	C₂₀H₂₂N₂O₃
Molecular Weight:	338.4 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Catharanthus roseus G. Don
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Muscle relaxants Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9551 mL	14.7754 mL	29.5508 mL	59.1017 mL	73.8771 mL
5 mM	0.591 mL	2.9551 mL	5.9102 mL	11.8203 mL	14.7754 mL
10 mM	0.2955 mL	1.4775 mL	2.9551 mL	5.9102 mL	7.3877 mL
50 mM	0.0591 mL	0.2955 mL	0.591 mL	1.182 mL	1.4775 mL
100 mM	0.0296 mL	0.1478 mL	0.2955 mL	0.591 mL	0.7388 mL

CFN96130	16-Epinormacusine B	126640-98-0	294.4	C₁₉H₂₂N₂O
CFN96747	Rauvotetraphylline A	1422506-49-7	342.43	C₂₀H₂₆N₂O₃
CFN96696	Rauvoyunine A	1414883-81-0	356.46	C₂₁H₂₈N₂O₃
CFN96067	Pericyclivine	975-77-9	322.4	C₂₀H₂₂N₂O₂
CFN90441	Perivine	2673-40-7	338.4	C₂₀H₂₂N₂O₃
CFN96242	Akuammidine	639-36-1	352.4	C₂₁H₂₄N₂O₃
CFN89174	Conodurine	2665-57-8	704.91	C₄₃H₅₂N₄O₅
CFN96750	Rauvotetraphylline C	1422506-51-1	510.58	C₂₈H₃₄N₂O₇
CFN96751	Rauvotetraphylline B	1422506-50-0	547.65	C₃₁H₃₇N₃O₆
CFN97884	Vellosimine	6874-98-2	292.4	C₁₉H₂₀N₂O