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    Phellamurin
    Phellamurin
    Information
    CAS No. 52589-11-4 Price
    Catalog No.CFN98863Purity> 95%
    Molecular Weight518.5 Type of CompoundFlavonoids
    FormulaC26H30O11Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)
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    Phellamurin Description
    Source: The barks of Phellodendron chinense Schneid.
    Biological Activity or Inhibitors: 1. Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadministration of Phellamurin or Phellodendron wilsonii with cyclosporin should be avoided.
    Solvent: Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9286 mL 9.6432 mL 19.2864 mL 38.5728 mL 48.216 mL
    5 mM 0.3857 mL 1.9286 mL 3.8573 mL 7.7146 mL 9.6432 mL
    10 mM 0.1929 mL 0.9643 mL 1.9286 mL 3.8573 mL 4.8216 mL
    50 mM 0.0386 mL 0.1929 mL 0.3857 mL 0.7715 mL 0.9643 mL
    100 mM 0.0193 mL 0.0964 mL 0.1929 mL 0.3857 mL 0.4822 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Phellamurin References Information
    Citation [1]

    Planta Med. 2002 Feb;68(2):138-41.

    Marked decrease of cyclosporin absorption caused by phellamurin in rats.[Pubmed: 11859464]
    Phellamurin is a flavonoid glycoside that is abundant in the leaves of Phellodendron wilsonii Hayata et Kanehira (Rutaceae). In vitro everted rat intestine study indicated that Phellamurin inhibited intestinal P-glycoprotein in a dose-dependent manner. In order to investigate the effect of Phellamurin on cyclosporin absorption and disposition, rats were given cyclosporin (5 mg/kg) with or without Phellamurin in a parallel design. Fluorescence polarization immunoassay was used to determine the blood concentration of cyclosporin. Unanticipatedly, our results indicated that the coadministration of Phellamurin significantly decreased the Cmax of cyclosporin by 77 % and reduced the AUC(0-infinity) of cyclosporin by 56 %. This indicated that a serious interaction occurred between Phellamurin with cyclosporin. To ensure the efficacy of cyclosporin, we suggest that the coadministration of Phellamurin or Phellodendron wilsonii with cyclosporin should be avoided.