| In vitro: |
| Planta Med. 1998 Feb;64(1):72-4. | | Pinusolidic acid: a platelet-activating factor inhibitor from Biota orientalis.[Pubmed: 9491770 ] |
METHODS AND RESULTS:
The water extract of Biota orientalis showed a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets using [3H]PAF as a ligand in our previous screening studies for Korean medicinal antagonists by the activity-guided purification studies. Another active compound, compound 1 (IC50 = 2.3 x 10(-5) M, 7.48 +/- 2.11 micrograms/ml, n = 4) was isolated from the title plant.
CONCLUSIONS:
The chemical structure of compound 1 was elucidated as Pinusolidic acid by chemical and spectrometric analyses. | | J Nat Prod. 2006 Apr;69(4):689-91. | | Neuroprotective diterpenes from the fruiting body of Antrodia camphorata.[Pubmed: 16643055] |
METHODS AND RESULTS:
Three new compounds, 19-hydroxylabda-8(17)-en-16,15-olide (1), 3beta,19-dihydroxylabda-8(17),11E-dien-16,15-olide (2), and 13-epi-3beta,19-dihydroxylabda-8(17),11E-dien-16,15-olide (3), together with four known compounds, 19-hydroxylabda-8(17),13-dien-16,15-olide (4), 14-deoxy-11,12-didehydroandrographolide (5), 14-deoxyandrographolide, and Pinusolidic acid, were isolated from the fruiting bodies of Antrodia camphorata. The structures of compounds 1-3 were elucidated by the analysis of their spectroscopic data.
CONCLUSIONS:
The in vitro neuroprotective activity of all compounds was evaluated, and compounds 1-5 protected neurons from Abeta damage by 39.2, 35.0, 36.7, 30.6, and 27.0%, respectively, at concentrations between 5 and 20 microM. |
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