ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
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More articles cited ChemFaces products.
The Korea Society of Pharmacognosy.2014New Zealand Journal of Forestry Sci.2014, 44:17J Sep Sci.2018 Jan 23.Journal of Pharmaceutical Analysis2016 May 5; Chemistr of plant2016021195
Oncotarget. 2016 Aug 19J Ethnopharmacol. 2017 Feb 23;Sci Rep. 2017 Jun 12;Sci Rep. 2016 Apr 27Fitoterapia.2015 Jan;100:179-86.
ScientificWorldJournal. 2014 Feb 9.Antiviral Res.2013 Jun;98(3):386-93.J Exp Bot. 2016 May 18.Int. Conference on Med. Sci. and Bio.2017;
Our products had been exported to the following research institutions and universities, And still growing.
University Medical Center Mainz (Germany)Donald Danforth Plant Science Ce... (USA)Subang Jaya Medical Centre (Malaysia)University of Toronto (Canada)
University of Vigo (Spain)Yale University (USA)National Chung Hsing University (Taiwan)St. Jude Children Research Hospi... (USA)
Centralised Purchases Unit (CPU)... (India)John Innes Centre (United Kingdom)National Hellenic Research Found... (Greece)
||Pseudoprotodioscin exhibits anti-inflammatory and anticancer activities, it shows a weaker suppressing effect on the production of inflammatory cytokines, and can suppress melanogenesis in B16F1 cells. |
||Immunology & Inflammation related|
|Planta Med. 2011 May;77(7):705-10. |
|Anti-inflammatory and anti-melanogenic steroidal saponin glycosides from Fenugreek (Trigonella foenum-graecum L.) seeds.[Pubmed: 20979021 ]|
|Fenugreek seed ( Trigonella foenum-graecum L.) is used as an herbal medicine for treating metabolic and nutritive dysfunctions. |
METHODS AND RESULTS:
To determine if this plant has other beneficial effects, we tested the inhibitory activities of a methanol (MeOH) extract of fenugreek seed on the production of inflammatory cytokines and melanin synthesis in cultured cell lines in vitro. The MeOH extract inhibited the production of phorbol-12-myristate-13-acetate-induced inflammatory cytokines such as tumor necrosis factor (TNF)-α in cultured THP-1 cells, and also restrained the intracellular synthesis of melanin in murine melanoma B16F1 cells. We isolated three active constituents from fenugreek seed extracts. These were identified as the steroidal saponins 26- O-β-D-glucopyranosyl-(25 R)-furost-5(6)-en-3 β,22 β,26-triol-3- O-α-L-rhamno-pyranosyl-(1'' → 2')-O-[β-D-glucopyranosyl-(1''' → 6')- O]-β-D-glucopyranoside 1, minutoside B 2, and Pseudoprotodioscin 3. Compounds 1 and 2 strongly suppressed the production of inflammatory cytokines, whereas 3 showed a weaker suppressing effect. Melanogenesis in B16F1 cells was significantly suppressed by 1 and 3, and weakly suppressed by 2. All three compounds showed moderate cytotoxicities.
These results indicate that fenugreek extract and its active constituents could protect against skin damage.
|Planta Med. 2001 Dec;67(9):853-7. |
|Two new steroidal saponins from the rhizomes of Dioscorea panthaica and their cytotoxic activity.[Pubmed: 11745024]|
|Two new steroidal saponins, dioscoresides C (1) and D (2), along with a new natural product, pregnadienolone 3-O-beta-gracillimatriose (3), and two known compounds, pregnadienolone 3-O-beta-chacotrioside (4) and Pseudoprotodioscin (5), were isolated from the rhizomes of Dioscorea panthaica Prain et Burkill. |
METHODS AND RESULTS:
On the basis of extensive NMR studies and chemical evidence, dioscoresides C and D were determined to be 26-O-beta-D-glucopyranosyl-3 beta,26-dihydroxy-23(S)-methoxy-25(R)-furosta-5,20(22)-dien-3-O-alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->4)]-beta-D-glucopyranoside and 26-O-beta-D-glucopyranosyl-3 beta,26-dihydroxy-20,22-seco-25(R)-furosta-5-en-20,22-dine-3-O-alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1--> 4)]-beta-D-glucopyranoside.
These compounds showed mild cytotoxicity against the cancer cell lines, A375, L929, and HeLa, in a dose-dependent manner.
||The rhizomes of Dioscorea nipponica Makino.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
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* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.