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    Quercetin-3-O-glucuronide
    Information
    CAS No. 22688-79-5 Price $318 / 10mg
    Catalog No.CFN92172Purity> 95%
    Molecular Weight478.4Type of CompoundFlavonoids
    FormulaC21H18O13Physical DescriptionYellow powder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)
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    Quercetin-3-O-glucuronide Description
    Source: The vines of Vitis vinifera
    Biological Activity or Inhibitors: 1. Quercetin-3-O-glucuronide has antioxidant activity.
    2. Quercetin-3-O-glucuronide is potent stilbene oxidase inhibitors.
    3. Quercetin-3-O-glucuronide is a potential anti-atherogenic metabolite, enhancing the anti-inflammatory properties of M2a macrophages and modulating immune response effects in the presence of pro-inflammatory stimuli.
    4. Quercetin-3-O-glucuronide is equally effective in inhibiting ROS-associated inflammation and ameliorating insulin resistant endothelial dysfunction by beneficial regulation of IRS-1 function.
    5. Quercetin-3-O-glucuronide significantly improves Alzheimer's disease (AD)-type deficits in hippocampal formation basal synaptic transmission and long-term potentiation, possibly through mechanisms involving the activation of the c-Jun N-terminal kinases and the mitogen-activated protein kinase signaling pathways.
    Solvent: Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0903 mL 10.4515 mL 20.903 mL 41.806 mL 52.2575 mL
    5 mM 0.4181 mL 2.0903 mL 4.1806 mL 8.3612 mL 10.4515 mL
    10 mM 0.209 mL 1.0452 mL 2.0903 mL 4.1806 mL 5.2258 mL
    50 mM 0.0418 mL 0.209 mL 0.4181 mL 0.8361 mL 1.0452 mL
    100 mM 0.0209 mL 0.1045 mL 0.209 mL 0.4181 mL 0.5226 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Quercetin-3-O-glucuronide References Information
    Citation [1]

    PLoS One. 2015 May 14;10(5):e0126481.

    Antimicrobial Air Filters Using Natural Euscaphis japonica Nanoparticles.[Pubmed: 25974109]
    High-performance liquid chromatography (HPLC) and electrospray ionization-tandem mass spectrometry (ESI/MS) analyses confirmed that the major chemical compounds in the E. japonica extract were 1(ß)-O-galloyl pedunculagin, Quercetin-3-O-glucuronide, and kaempferol-3-O-glucoside. In vitro cytotoxicity and disk diffusion tests showed that E. japonica nanoparticles were less toxic and exhibited stronger antimicrobial activity toward some bacterial strains than a reference soluble nickel compound, which is classified as a human carcinogen. This study provides valuable information for the development of a bioaerosol control system that is environmental friendly and suitable for use in indoor environments.
    Citation [2]

    PLoS One. 2015 Apr 15;10(4):e0121784.

    Quercetin represses apolipoprotein B expression by inhibiting the transcriptional activity of C/EBPβ.[Pubmed: 25875015]
    We found that quercetin inhibits the transcriptional activity of C/EBPβ but not its recruitment to the apoB promoter. On the exposure of Caco-2 cells to Quercetin-3-O-glucuronide, which is in a cell-impermeable form, no notable change in apoB mRNA was observed, suggesting an intracellular action of quercetin. In vitro interaction experiments using quercetin-conjugated beads revealed that quercetin binds to C/EBPβ. Our results describe a novel regulatory mechanism of transcription of apolipoprotein genes by quercetin in the intestinal enterocytes.