Quinovic acid | CAS:465-74-7 | Manufacturer ChemFaces

Quinovic acid

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Description:

Quinovic acid shows some anti-tumour activities, quinovic acid glycosides have a potent inhibitory effect on the growth of human bladder cancer cell lines by inducing apoptosis through modulation of NF-κB.

Targets:

Caspase | NF-kB

In vitro:

Food Chem Toxicol. 2014 May;67:222-9.

Quinovic acid glycosides purified fraction from Uncaria tomentosa induces cell death by apoptosis in the T24 human bladder cancer cell line.[Pubmed: 24607820]

Bladder cancer is the second most prevalent malignancy in the genitourinary tract and remains a therapeutic challenge. In the search for new treatments, researchers have attempted to find compounds with low toxicity. With this goal in mind, Uncaria tomentosa is noteworthy because the bark and root of this species are widely used in traditional medicine and in adjuvant therapy for the treatment of numerous diseases.
METHODS AND RESULTS:
The objective of this study was to investigate the antitumor effect of one purified bioactive fraction of U.tomentosa bark on cell proliferation in two human bladder cancer cell lines, T24 and RT4. Quinovic acid glycosides purified fraction (QAPF) of U.tomentosa decreased the growth and viability of both T24 and RT4 cell lines. In T24 cells, QAPF induced apoptosis by activating caspase-3 and NF-κB. Further study showed that this fraction does not induce cell cycle arrest and does not alter PTEN and ERK levels.
CONCLUSIONS:
In conclusion, we demonstrated that QAPF of U.tomentosa has a potent inhibitory effect on the growth of human bladder cancer cell lines by inducing apoptosis through modulation of NF-κB, and we suggest that QAPF may become a potential therapeutic agent for the prevention and/or treatment of this cancer.

Quinovic acid Description

Source:	The barks of Zygophyllum fabago L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Quinovic acid
Price:
CAS No.:	465-74-7
Catalog No.:	CFN98694
Molecular Formula:	C₃₀H₄₆O₅
Molecular Weight:	486.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The barks of Zygophyllum fabago L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Pro-apoptotic Compound Library Triterpenoids Compound Library NF-kB Inhibitor Library Caspase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0547 mL	10.2733 mL	20.5465 mL	41.0931 mL	51.3663 mL
5 mM	0.4109 mL	2.0547 mL	4.1093 mL	8.2186 mL	10.2733 mL
10 mM	0.2055 mL	1.0273 mL	2.0547 mL	4.1093 mL	5.1366 mL
50 mM	0.0411 mL	0.2055 mL	0.4109 mL	0.8219 mL	1.0273 mL
100 mM	0.0205 mL	0.1027 mL	0.2055 mL	0.4109 mL	0.5137 mL

CFN97217	27-p-Coumaroyloxyursolic acid	73584-67-5	618.9	C₃₉H₅₄O₆
CFN98694	Quinovic acid	465-74-7	486.7	C₃₀H₄₆O₅
CFN99060	Quinovic acid 3-O-alpha-L-rhamnopyranoside	104055-76-7	632.8	C₃₆H₅₆O₉
CFN99084	Quinovin	107870-05-3	632.8	C₃₆H₅₆O₉
CFN99850	Quinovic acid 3-O-(3',4'-O-isopropylidene)-beta-D-fucopyranoside	182132-59-8	672.9	C₃₉H₆₀O₉
CFN97273	Quinovic acid 3-O-beta-D-glucoside	79955-41-2	648.8	C₃₆H₅₆O₁₀
CFN99801	Rubelloside B	167875-39-0	795.0	C₄₂H₆₆O₁₄
CFN99361	Quinovic acid 3-O-(6-deoxy-beta-D-glucopyranoside) 28-O-beta-D-glucopyranosyl ester	124727-10-2	795.0	C₄₂H₆₆O₁₄