|Source:||The fruits of Schizandra chinensis|
|Biological Activity or Inhibitors:|| 1. (+/-)-Gomisin M1 exhibits potent anti-HIV activity, with EC50 and therapeutic index (TI) values of <0.65 microM and >68, respectively.
|Solvent:||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||2.588 mL||12.94 mL||25.8799 mL||51.7598 mL||64.6998 mL|
|5 mM||0.5176 mL||2.588 mL||5.176 mL||10.352 mL||12.94 mL|
|10 mM||0.2588 mL||1.294 mL||2.588 mL||5.176 mL||6.47 mL|
|50 mM||0.0518 mL||0.2588 mL||0.5176 mL||1.0352 mL||1.294 mL|
|100 mM||0.0259 mL||0.1294 mL||0.2588 mL||0.5176 mL||0.647 mL|
Planta Med 1984; 50(5): 414-417
|Studies on the Chemical Constituents of Kadsura longipedunculata: Isolation and Structure Elucidation of Five New Lignans[Reference: WebLink]|
|Five new dibenzocyclooctadiene lignans, R(+)-wuweizisu C (1), kadsuranin (2), R(+)-Gomisin M1 (3), R(+)-angeloylgomisin M1 (4) and angeloylgomisin R (5) were isolated from the ethereal extract of roots and stems of Kadsura longipedunculata Finet et Gagnep. Their structures were elucidated on the basis of chemical and spectral analysis.|
J Nat Prod. 2006 Dec;69(12):1697-701.
|Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora.[Pubmed: 17190445 ]|
|Bioactivity-directed fractionation of an ethanolic extract of the fruits of Schisandra rubriflora led to the isolation and identification of dibenzocyclooctadiene lignans including the new lignans rubrisandrins A (1a + 1b) and B (2) and the known lignans gomisin J (3), (+/-)-gomisin M1 (R(+)-Gomisin M1,4), (+)-gomisin M2 (5), schisanhenol (6), deoxyschisandrin, schisantherin B, schisandrin, tigloylgomisin P, gomisin O, angeloylgomisin P, and epigomisin O. Their structure and stereochemistry were determined by spectroscopic methods, including 2D-NMR techniques. Compounds 1 and 3-6 were active as anti-HIV agents. (+/-)-Gomisin M1 (R(+)-Gomisin M1,4) exhibited the most potent anti-HIV activity, with EC50 and therapeutic index (TI) values of <0.65 microM and >68, respectively.|