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Retusamine
Retusamine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Retusamine
Price:
CAS No.: 6883-16-5
Catalog No.: CFN00410
Molecular Formula: C19H25NO7
Molecular Weight: 379.41 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Crotalaria pallida
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Retusamine is a natural product from Crotalaria pallida.
In vitro:
Chem Biol Interact. 1976 Mar;12(3-4):299-324.
Hepato- and pneumotoxicity of pyrrolizidine alkaloids and derivatives in relation to molecular structure.[Pubmed: 1253333]

METHODS AND RESULTS:
The following compounds are readily converted by rat liver microsomes in vitro into dehydroheliotridine (or dehydroretronecine): 7- and 9-angelyheliotridine, 7- and 9-angelylretronecine, 7,9-dipivalylheliotridine and otosenine. 7,9-Divalerylheliotridine, the alpha- and beta-epoxides of monocrotaline, and Retusamine yield pyrrolic metabolites more slowly. The preparation and characterisation of several alkaloid derivatives are described. Chronic lung lesions were produced by most compounds which gave chronic liver lesions, although a higher dose was required in some instances.
CONCLUSIONS:
This requirement may sometimes mean that chronic lung lesions cannot be induced because of the intervention of acute or peracute deaths. Apart from this factor, structure activity requirements for pneumotoxicity are the same as for hepatotoxicity, consistent with their being both caused by the same toxic metabolites.
Retusamine Description
Source: The herbs of Crotalaria pallida
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6357 mL 13.1784 mL 26.3567 mL 52.7134 mL 65.8918 mL
5 mM 0.5271 mL 2.6357 mL 5.2713 mL 10.5427 mL 13.1784 mL
10 mM 0.2636 mL 1.3178 mL 2.6357 mL 5.2713 mL 6.5892 mL
50 mM 0.0527 mL 0.2636 mL 0.5271 mL 1.0543 mL 1.3178 mL
100 mM 0.0264 mL 0.1318 mL 0.2636 mL 0.5271 mL 0.6589 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Oxypeucedanin hydrate

Catalog No: CFN90557
CAS No: 2643-85-8
Price: $80/20mg
Neomangiferin

Catalog No: CFN98122
CAS No: 64809-67-2
Price: $80/20mg
Kukoamine A

Catalog No: CFN93215
CAS No: 75288-96-9
Price: $ / mg
Echinocystic acid

Catalog No: CFN98812
CAS No: 510-30-5
Price: $60/20mg
10-Shogaol

Catalog No: CFN92300
CAS No: 36752-54-2
Price: $138/20mg
(-)-Syringaresinol

Catalog No: CFN92500
CAS No: 6216-81-5
Price: $268/10mg
Citropten

Catalog No: CFN97963
CAS No: 487-06-9
Price: $60/20mg
Byakangelicol

Catalog No: CFN98167
CAS No: 26091-79-2
Price: $118/20mg
Sennoside B

Catalog No: CFN99904
CAS No: 128-57-4
Price: $40/20mg
Isomangiferin

Catalog No: CFN90385
CAS No: 24699-16-9
Price: $238/20mg
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