Rubiyunnanin C | CAS:1261030-04-9 | Manufacturer ChemFaces

Rubiyunnanin C

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Licochalcone B

Catalog No: CFN99576
CAS No: 58749-23-8
Price: $268/20mg

Senkyunolide A

Catalog No: CFN99594
CAS No: 62006-39-7
Price: $90/20mg

Tenuifolin

Catalog No: CFN98157
CAS No: 20183-47-5
Price: $100/20mg

11-Hydroxy-sugiol

Catalog No: CFN90366
CAS No: 88664-08-8
Price: $490/5mg

Ganoderic acid H

Catalog No: CFN92056
CAS No: 98665-19-1
Price: $318/10mg

Cucurbitacin B

Catalog No: CFN99129
CAS No: 6199-67-3
Price: $70/20mg

Corilagin

Catalog No: CFN90176
CAS No: 23094-69-1
Price: $50/20mg

Rebaudioside F

Catalog No: CFN95215
CAS No: 438045-89-7
Price: $268/5mg

Dehydrotrametenolic acid

Catalog No: CFN90577
CAS No: 29220-16-4
Price: $188/20mg

Chebulinic acid

Catalog No: CFN92296
CAS No: 18942-26-2
Price: $138/20mg

Description:

Rubiyunnanin C exhibits cytotoxic activities against a panel of eleven cancer cell lines and exerts inhibitory activities against nitric oxide (NO) production in LPS and IFN-γ-induced RAW 264.7 murine macrophages.

Targets:

NO | IFN-γ | TNF-α | NF-kB

In vitro:

Bioorg Med Chem. 2010 Dec 1;18(23):8226-34.

Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-κB activation.[Pubmed: 21044847 ]

Six new (Rubiyunnanin C,rubiyunnanin D, rubiyunnanin E, rubiyunnanin F, rubiyunnanin G, rubiyunnanin H, 1-6) and five known (7-11) cyclic hexapeptides were isolated from the roots of Rubiayunnanensis (Franch.) Diels.
METHODS AND RESULTS:
The structures and stereochemistry of 1-6 were established by extensive spectroscopic analyses and chemical methods. All compounds (1-11) not only exhibited cytotoxic activities against a panel of eleven cancer cell lines with IC₅₀ values ranging from 0.001 to 56.24 μM, but also exerted inhibitory activities against nitric oxide (NO) production in LPS and IFN-γ-induced RAW 264.7 murine macrophages with IC₅₀ values ranging from 0.05 to 12.68 μM.
CONCLUSIONS:
Furthermore, this is the first time it is being reported that compounds 2 and 7-10 significantly inhibited TNF-α-induced NF-κB activation in HEK-293-NF-κB luciferase stable cells with IC₅₀ values of 35.07, 0.03, 1.69, 12.64 and 1.18 μM, respectively.

Rubiyunnanin C Description

Source:	The herbs of Rubia yunnanensis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Rubiyunnanin C
Price:
CAS No.:	1261030-04-9
Catalog No.:	CFN91927
Molecular Formula:	C₄₃H₅₂N₆O₁₁
Molecular Weight:	828.91 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Rubia yunnanensis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library TNF-α Inhibitor Library NO Inhibitor Library NF-kB Inhibitor Library IFN-γ Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.2064 mL	6.032 mL	12.064 mL	24.1281 mL	30.1601 mL
5 mM	0.2413 mL	1.2064 mL	2.4128 mL	4.8256 mL	6.032 mL
10 mM	0.1206 mL	0.6032 mL	1.2064 mL	2.4128 mL	3.016 mL
50 mM	0.0241 mL	0.1206 mL	0.2413 mL	0.4826 mL	0.6032 mL
100 mM	0.0121 mL	0.0603 mL	0.1206 mL	0.2413 mL	0.3016 mL

CFN90279	Cyclo(Tyr-Hpro)	813461-21-1	276.29	C₁₄H₁₆N₂O₄
CFN90277	Cyclo(Pro-Trp)	67889-75-2	283.33	C₁₆H₁₇N₃O₂
CFN96937	Demethoxyfumitremorgin C	111768-16-2	349.43	C₂₁H₂₃N₃O₂
CFN96930	Fumitremorgin C	118974-02-0	379.46	C₂₂H₂₅N₃O₃
CFN89011	Fumitremorgin B	12626-17-4	479.57	C₂₇H₃₃N₃O₅
CFN90627	Heterophyllin B	145459-19-4	778.95	C₄₀H₅₈N₈O₈
CFN91927	Rubiyunnanin C	1261030-04-9	828.91	C₄₃H₅₂N₆O₁₁
CFN95187	Astin A	151201-75-1	586.5	C₂₅H₃₃N₅O₇Cl₂
CFN95188	Astin B	151201-76-2	586.5	C₂₅H₃₃N₅O₇Cl₂
CFN95189	Astin C	148057-23-2	570.5	C₂₅H₃₃N₅O₆Cl₂