Salaspermic acid | CAS:71247-78-4 | Manufacturer ChemFaces

Salaspermic acid

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Salaspermic acid is an inhibitor of HIV reverse transcriptase and HIV replication in H9 lymphocyte cells.

Targets:

HIV

In vitro:

J Nat Prod. 1994 Jan;57(1):1-8.

Quinone-methide triterpenes and salaspermic acid from Kokoona ochracea.[Pubmed: 8158155]

METHODS AND RESULTS:
Tingenone[1],20-hydroxy-20-epi-tingenone[2],celastrol[ 3], and Salaspermic acid [4] have been isolated from Kokoona ochracea stem bark. The quinone-methide triterpenes 1-3 exhibited strong but non-specific in vitro cytotoxicity against P-388 murine lymphocytic leukemia cells and a panel of human cancer cell lines. Salaspermic acid [4] was not active in all the cancer cell lines used in this investigation.
CONCLUSIONS:
13C-nmr spectra assignments for Salaspermic acid have been accomplished through the application of 1D and 2D nmr spectral techniques, and 13C-nmr assignments for celastrol [3] have been revised.

J Nat Prod. 1992 Mar;55(3):340-6.

Anti-aids agents, 6. Salaspermic acid, an anti-HIV principle from Tripterygium wilfordii, and the structure-activity correlation with its related compounds.[Pubmed: 1375626]

METHODS AND RESULTS:
Salaspermic acid [1], an inhibitor of HIV reverse transcriptase and HIV replication in H9 lymphocyte cells, was isolated from the roots of Tripterygium wilfordii for the first time. The structure of 1 derived from spectral data was established unequivocally by an X-ray analysis of crystals of the monohydrate.
CONCLUSIONS:
A structure-activity correlation of 1 with ten related compounds indicated that the acetal linkage in ring A and the carboxyl group in ring E of 1 may be required for the anti-HIV activity.

Salaspermic acid Description

Source:	The stem barks of Kokoona ochracea.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Salaspermic acid
Price:
CAS No.:	71247-78-4
Catalog No.:	CFN96837
Molecular Formula:	C₃₀H₄₈O₄
Molecular Weight:	472.71 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The stem barks of Kokoona ochracea.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antiviral Compound Library Triterpenoids Compound Library HIV Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1155 mL	10.5773 mL	21.1546 mL	42.3092 mL	52.8865 mL
5 mM	0.4231 mL	2.1155 mL	4.2309 mL	8.4618 mL	10.5773 mL
10 mM	0.2115 mL	1.0577 mL	2.1155 mL	4.2309 mL	5.2887 mL
50 mM	0.0423 mL	0.2115 mL	0.4231 mL	0.8462 mL	1.0577 mL
100 mM	0.0212 mL	0.1058 mL	0.2115 mL	0.4231 mL	0.5289 mL

CFN96837	Salaspermic acid	71247-78-4	472.71	C₃₀H₄₈O₄
CFN89150	Canophyllal	14440-40-5	440.71	C₃₀H₄₈O₂
CFN98260	Bryonolic acid	24480-45-3	456.7	C₃₀H₄₈O₃
CFN99152	Glycyrrhetinic acid	471-53-4	470.64	C₃₀H₄₆O₄
CFN97747	28-Hydroxy-3-oxoolean-12-en-29-oic acid	381691-22-1	470.69	C₃₀H₄₆O₄
CFN99487	22-Hydroxy-3-oxoolean-12-en-29-oic acid	144629-84-5	470.7	C₃₀H₄₆O₄
CFN97288	3,22-Dihydroxyolean-12-en-29-oic acid	808769-54-2	472.7	C₃₀H₄₈O₄
CFN98018	Triptocallic acid D	201534-09-0	472.7	C₃₀H₄₈O₄
CFN96474	Triptotriterpenic acid A	84108-17-8	472.70	C₃₀H₄₈O₄
CFN97335	Wilforlide A	84104-71-2	454.7	C₃₀H₄₆O₃