Savinin | CAS:493-95-8 | Manufacturer ChemFaces

Savinin

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Description:

Savinin has antiinflammatory effect, can significantly inhibit tumor necrosis factor (TNF)-a production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells, and T cell proliferation elicited by concanavalin (Con A), without displaying cytotoxicity. Savinin also exhibits potent spermicidal activity and significant insecticidal activity.

Targets:

TNF-α

In vitro:

Phytochemistry. 2001 Apr;56(8):857-61.

Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum.[Pubmed: 11324918 ]

METHODS AND RESULTS:
Two benzophenanthrene alkaloids, 8-acetonyldihydronitidine and 8-acetonyldihydroavicine were isolated from Zanthoxylum tetraspermum stem bark along with liriodenine, sesamin, lichexanthone and (+)-piperitol-gamma,gamma-dimethylallylether. The species endemic to Sri Lanka, Z. caudatum, contained sesamin, Savinin, liriodenine, decarine and 8-O-desmethyl-N-nornitidine.
CONCLUSIONS:
8-Acetonyldihydronitidine and 8-acetonyldihydroavicine showed significant antibacterial activity while the former along with liriodenine was strongly antifungal. Savinin exhibited potent spermicidal activity. Both Savinin and sesamin exhibited significant insecticidal activity.

Savinin Description

Source:	The heartwoods of Pterocarpus santalinus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Biol Pharm Bull. 2001 Feb;24(2):167-71.

Savinin, a lignan from Pterocarpus santalinus inhibits tumor necrosis factor-alpha production and T cell proliferation.[Pubmed: 11217086]

METHODS AND RESULTS:
Two lignans were isolated from the heartwood of Pterocarpus santalinus by activity-guided fractionation and investigated for their biological properties and molecular mechanism of action. On the basis of their spectroscopic data, these compounds were identified as Savinin (1) and calocedrin (2), dibenzyl butyrolactone-type lignan compounds having an alpha-arylidene gamma-lactone structure. These lignans significantly inhibited tumor necrosis factor (TNF)-a production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells, and T cell proliferation elicited by concanavalin (Con A), without displaying cytotoxicity. The molecular inhibitory mechanism of compound 1 was confirmed to be mediated by the non-polar butyrolactone ring, according to a structure-relationship study with structurally related and unrelated compounds, such as arctigenin (a dibenzyl butyrolactone type lignan), eudesmin (a furofuran type lignan), isolariciresinol (a dibenzylbutane type lignan), and cynaropicrin (a sesquiterpene lactone).
CONCLUSIONS:
The results suggest that Savinin may act as an active principle in the reported biological activities of P. santalinus, such as antiinflammatory effect, by mediation of the butyrolactone ring as a valuable pharmacophore.

Product Name	Savinin
Price:
CAS No.:	493-95-8
Catalog No.:	CFN98786
Molecular Formula:	C₂₀H₁₆O₆
Molecular Weight:	352.3 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Powder
Source:	The heartwoods of Pterocarpus santalinus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Insecticides Compound Library Lignans Compound Library TNF-α Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8385 mL	14.1924 mL	28.3849 mL	56.7698 mL	70.9622 mL
5 mM	0.5677 mL	2.8385 mL	5.677 mL	11.354 mL	14.1924 mL
10 mM	0.2838 mL	1.4192 mL	2.8385 mL	5.677 mL	7.0962 mL
50 mM	0.0568 mL	0.2838 mL	0.5677 mL	1.1354 mL	1.4192 mL
100 mM	0.0284 mL	0.1419 mL	0.2838 mL	0.5677 mL	0.7096 mL

CFN97230	5-Acetoxymatairesinol dimethyl ether	74892-45-8	444.5	C₂₄H₂₈O₈
CFN92059	Pluviatolide	28115-68-6	356.4	C₂₀H₂₀O₆
CFN97234	Kaerophyllin	75590-33-9	368.4	C₂₁H₂₀O₆
CFN99313	Meridinol	120051-54-9	370.4	C₂₀H₁₈O₇
CFN98786	Savinin	493-95-8	352.3	C₂₀H₁₆O₆
CFN95010	Suchilactone	50816-74-5	368.4	C₂₁H₂₀O₆
CFN95008	Isonemerosin	181524-79-8	398.4	C₂₂H₂₂O₇
CFN97895	2,3-Di(3',4'-methylenedioxybenzyl)-2-buten-4-olide	137809-97-3	352.3	C₂₀H₁₆O₆
CFN99396	7-Oxohinokinin	130837-92-2	368.3	C₂₀H₁₆O₇
CFN95243	Neoarctin B	155969-67-8	742.8	C₄₂H₄₆O₁₂