ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
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More articles cited ChemFaces products.
Analytical sci. & Tech2016Virulence.2018 Jan 1;J. Soc. Cosmet. Sci. KoreaJune 2016Int J Mol Sci. 2017 May 11;BMC Complement Altern Med.2017 Aug 9;
FEBS Lett.2015 Jan 2;589(1):182-7. Curr Eye Res.2018 Jan;PhytomedicineFeb. 11. 2016Sci Rep. 2017 Oct 11;PLoS One. 2017 Aug 8;
Integr Med Res.2017 Dec;Evid Based Complement Alternat Med. 2018;Lab On a Chip21 Feb 2018;Research on Crops.2017, Issue : 3
Our products had been exported to the following research institutions and universities, And still growing.
University of Padjajaran (Indonesia)Gyeongsang National University (Korea)Mahatma Gandhi University (India)Universidad Industrial de Santan... (Colombia)
Nicolaus Copernicus Uniwersity (Poland)University of Cincinnati (USA)Monash University (Australia)VIT University (India)
Medical University of South Caro... (USA)University of Mysore (India)University of British Columbia (Canada)
||Savinin has antiinflammatory effect, can significantly inhibit tumor necrosis factor (TNF)-a production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells, and T cell proliferation elicited by concanavalin (Con A), without displaying cytotoxicity. Savinin also exhibits potent spermicidal activity and significant insecticidal activity. |
|Phytochemistry. 2001 Apr;56(8):857-61. |
|Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum.[Pubmed: 11324918 ]|
METHODS AND RESULTS:
Two benzophenanthrene alkaloids, 8-acetonyldihydronitidine and 8-acetonyldihydroavicine were isolated from Zanthoxylum tetraspermum stem bark along with liriodenine, sesamin, lichexanthone and (+)-piperitol-gamma,gamma-dimethylallylether. The species endemic to Sri Lanka, Z. caudatum, contained sesamin, Savinin, liriodenine, decarine and 8-O-desmethyl-N-nornitidine.
8-Acetonyldihydronitidine and 8-acetonyldihydroavicine showed significant antibacterial activity while the former along with liriodenine was strongly antifungal. Savinin exhibited potent spermicidal activity. Both Savinin and sesamin exhibited significant insecticidal activity.
||The heartwoods of Pterocarpus santalinus
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Biol Pharm Bull. 2001 Feb;24(2):167-71. |
|Savinin, a lignan from Pterocarpus santalinus inhibits tumor necrosis factor-alpha production and T cell proliferation.[Pubmed: 11217086]|
METHODS AND RESULTS:
Two lignans were isolated from the heartwood of Pterocarpus santalinus by activity-guided fractionation and investigated for their biological properties and molecular mechanism of action. On the basis of their spectroscopic data, these compounds were identified as Savinin (1) and calocedrin (2), dibenzyl butyrolactone-type lignan compounds having an alpha-arylidene gamma-lactone structure. These lignans significantly inhibited tumor necrosis factor (TNF)-a production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells, and T cell proliferation elicited by concanavalin (Con A), without displaying cytotoxicity. The molecular inhibitory mechanism of compound 1 was confirmed to be mediated by the non-polar butyrolactone ring, according to a structure-relationship study with structurally related and unrelated compounds, such as arctigenin (a dibenzyl butyrolactone type lignan), eudesmin (a furofuran type lignan), isolariciresinol (a dibenzylbutane type lignan), and cynaropicrin (a sesquiterpene lactone).
The results suggest that Savinin may act as an active principle in the reported biological activities of P. santalinus, such as antiinflammatory effect, by mediation of the butyrolactone ring as a valuable pharmacophore.