Science | Nature | Cell | View More
Natural Products
Schisanlactone A
Schisanlactone A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Schisanlactone A
Price:
CAS No.: 87164-31-6
Catalog No.: CFN92212
Molecular Formula: C30H40O4
Molecular Weight: 464.7 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The herbs of Kadsura longipedunculata Finet.et Gagnep
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Center for protein Engineering ... (Belgium)
  • Ateneo de Manila University (Philippines)
  • University of East Anglia (United Kingdom)
  • Lund University (Sweden)
  • Kitasato University (Japan)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Chulalongkorn University (Thailand)
  • Stanford University (USA)
  • Heidelberg University (Germany)
  • Charles Sturt University (Denmark)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • More...
Package
Featured Products
Magnolol

Catalog No: CFN98872
CAS No: 528-43-8
Price: $30/20mg
L-Arginine

Catalog No: CFN90550
CAS No: 74-79-3
Price: $30/20mg
Ginsenoside Rg6

Catalog No: CFN90565
CAS No: 147419-93-0
Price: $268/5mg
Corosolic acid

Catalog No: CFN98685
CAS No: 4547-24-4
Price: $60/20mg
Atractylenolide III

Catalog No: CFN99946
CAS No: 73030-71-4
Price: $70/20mg
p-Cymene

Catalog No: CFN70239
CAS No: 99-87-6
Price: $30/20mg
Ginsenoside MC

Catalog No: CFN95232
CAS No: 175484-06-7
Price: $318/10mg
alpha-Viniferin

Catalog No: CFN97068
CAS No: 62218-13-7
Price: $318/10mg
(+)-Epipinoresinol

Catalog No: CFN92288
CAS No: 24404-50-0
Price: $338/5mg
Betaine

Catalog No: CFN99546
CAS No: 107-43-7
Price: $30/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Schisanlactone A is a dimerization inhibitor, with an IC50 value of 5.0 microg/mL; it also shows appreciable inhibitory activity against HIV-1 protease with the IC50 value of 20 microM. Schisanlactone A shows cytotoxicity against KB (a human epidermal carcinoma) cells with the IC50 value of 63.3 uM.
Targets: HIV
In vitro:
J Nat Prod. 2009 Nov;72(11):2019-23.
Inhibition of the dimerization and active site of HIV-1 protease by secondary metabolites from the Vietnamese mushroom Ganoderma colossum.[Pubmed: 19813754 ]

METHODS AND RESULTS:
A new farnesyl hydroquinone, ganomycin I (1), was isolated along with ganomycin B (2) from the chloroform extract of the fruiting bodies of the Vietnamese mushroom Ganoderma colossum. These compounds inhibited HIV-1 protease with IC50 values of 7.5 and 1.0 microg/mL, respectively.
CONCLUSIONS:
Kinetic studies using Zhang-Poorman and Lineweaver plots revealed that compound 2 competitively inhibited the active site of the enzyme, whereas the tetracyclic triterpene Schisanlactone A, previously isolated from the same fungus, was a dimerization inhibitor, with an IC50 value of 5.0 microg/mL. The previous findings were also confirmed by the virtual docking of both compounds with HIV-1 protease crystal structure.
Fitoterapia. 2013 Dec;91:125-7.
Cattienoids A-C, three novel steroids from the mushroom Tomophagus cattienensis.[Pubmed: 24001711 ]

METHODS AND RESULTS:
Three novel steroids (1-3), named cattienoids A-C together with Schisanlactone A (4), were isolated from fruiting bodies of Tomophagus cattienensis (Ganodermataceae)-a new mushroom recently collected from Cattien National Park, in Viet Nam. They possess an unusual seven membered lactone ring, derived from lanostane-type triterpenoids. Their structures were determined by spectroscopic methods. In addition, compounds 2 and 4 showed cytotoxicity against KB (a human epidermal carcinoma) cells with their IC50 values of 91.2 and 63.3 μM, respectively.
CONCLUSIONS:
These compounds have neither antimicrobial activity nor inhibition of the tyrosinase.
Schisanlactone A Description
Source: The herbs of Kadsura longipedunculata Finet.et Gagnep
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
(1S,2S)-threo-Honokitriol

Catalog No: CFN95076
CAS No: 1099687-80-5
Price: $413/5mg
New compound 20

Catalog No: CFN95545
CAS No: N/A
Price: $413/5mg
3',8-Dihydroxyvestitol

Catalog No: CFN95384
CAS No: 122587-87-5
Price: $413/5mg
Sophoraflavone A

Catalog No: CFN95510
CAS No: 105594-08-9
Price: $318/10mg
Oxytroflavoside F

Catalog No: CFN95489
CAS No: 1391144-85-6
Price: $318/5mg
3,4-O-dimethylcedrusin

Catalog No: CFN95026
CAS No: 166021-14-3
Price: $388/10mg
3-Methoxyshancigusin I

Catalog No: CFN95062
CAS No: N/A
Price: $413/5mg
Mirificin-4'-O-glucoside

Catalog No: CFN95091
CAS No: 168035-01-6
Price: $288/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1519 mL 10.7596 mL 21.5193 mL 43.0385 mL 53.7981 mL
5 mM 0.4304 mL 2.1519 mL 4.3039 mL 8.6077 mL 10.7596 mL
10 mM 0.2152 mL 1.076 mL 2.1519 mL 4.3039 mL 5.3798 mL
50 mM 0.043 mL 0.2152 mL 0.4304 mL 0.8608 mL 1.076 mL
100 mM 0.0215 mL 0.1076 mL 0.2152 mL 0.4304 mL 0.538 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chem Pharm Bull (Tokyo). 2006 Jan;54(1):129-32.
Three new lignans, longipedunins A-C, from Kadsura longipedunculata and their inhibitory activity against HIV-1 protease.[Pubmed: 16394567]

METHODS AND RESULTS:
Three new lignans, longipedunins A (1), B (2) and C (3), together with three known compounds, benzoyl-binankadsurin A (4), acetyl-binankadsurin A (5) and Schisanlactone A (6), were isolated from Kadsura longipedunculata. Their structures and stereochemistry were determined by spectral and single-crystal X-ray analyses.
CONCLUSIONS:
Compounds 1 and 6 showed appreciable inhibitory activity against HIV-1 protease with IC50 values of 50 and 20 microM, respectively.
Magnolol

Catalog No: CFN98872
CAS No: 528-43-8
Price: $30/20mg
L-Arginine

Catalog No: CFN90550
CAS No: 74-79-3
Price: $30/20mg
Ginsenoside Rg6

Catalog No: CFN90565
CAS No: 147419-93-0
Price: $268/5mg
Corosolic acid

Catalog No: CFN98685
CAS No: 4547-24-4
Price: $60/20mg
Atractylenolide III

Catalog No: CFN99946
CAS No: 73030-71-4
Price: $70/20mg
p-Cymene

Catalog No: CFN70239
CAS No: 99-87-6
Price: $30/20mg
Ginsenoside MC

Catalog No: CFN95232
CAS No: 175484-06-7
Price: $318/10mg
alpha-Viniferin

Catalog No: CFN97068
CAS No: 62218-13-7
Price: $318/10mg
(+)-Epipinoresinol

Catalog No: CFN92288
CAS No: 24404-50-0
Price: $338/5mg
Betaine

Catalog No: CFN99546
CAS No: 107-43-7
Price: $30/20mg
Tags: buy Schisanlactone A | Schisanlactone A supplier | purchase Schisanlactone A | Schisanlactone A cost | Schisanlactone A manufacturer | order Schisanlactone A | Schisanlactone A distributor