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Sendanolactone
Sendanolactone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Sendanolactone
Price:
CAS No.: 64929-59-5
Catalog No.: CFN97113
Molecular Formula: C30H42O4
Molecular Weight: 466.7 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The barks of Melia azedarach
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Sendanolactone possesses moderate cytotoxic activity against KB cell lines.
Sendanolactone Description
Source: The barks of Melia azedarach
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1427 mL 10.7135 mL 21.427 mL 42.8541 mL 53.5676 mL
5 mM 0.4285 mL 2.1427 mL 4.2854 mL 8.5708 mL 10.7135 mL
10 mM 0.2143 mL 1.0714 mL 2.1427 mL 4.2854 mL 5.3568 mL
50 mM 0.0429 mL 0.2143 mL 0.4285 mL 0.8571 mL 1.0714 mL
100 mM 0.0214 mL 0.1071 mL 0.2143 mL 0.4285 mL 0.5357 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Australian Journal of Chemistry , 2002 , 55 (4) :291-296
New Terpenoids from the Roots of Melia azedarach[Reference: WebLink]

METHODS AND RESULTS:
Two new terpenoids, bakayanolide (1) and 2α-hydroxy-3β-methoxy-6-oxo-13α,14β,17α-lanosta-7,24-dien-21,16β-olide (2), together with the known compounds 6β-hydroxy-3-oxo-13α,14β,17α-lanosta-7,24-dien-21,16β-olide (3), Sendanolactone (4), kulactone (5), and β-sitosterol have been isolated from the ethanolic root extracts of Melia azedarach. Triterpenoids (4), (5), and β-sitosterol have been identified previously from M. azedarach, while it is the first instance of the isolation of (3) from this source. The identity of these compounds was established through extensive spectroscopic methods (infrared and mass spectroscopy, 1H and 13C nuclear magnetic resonance) as well as appropriate two-dimensional nuclear magnetic resonance experiments.
CONCLUSIONS:
Bakayanolide (1) belongs to the rare class of C11 odd terpenes. Compounds (3) and (4) possessed moderate cytotoxic activity against KB cell lines.
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