Senecionine N-oxide | CAS:13268-67-2 | Manufacturer ChemFaces

Senecionine N-oxide

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $227.8 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Senecionine N-oxide and senecionine have hepatotoxic activity, no antifertility effects in MeOH extract-treated hamsters.

In vivo:

Funct Dev Morphol. 1994;4(2):89-92.

Differing embryotoxic effects of senecionine and senecionine-N-oxide on the chick embryo.[Pubmed: 7873804 ]

METHODS AND RESULTS:
The embryotoxic properties of pyrrolizidine alkaloids senecionine (water insoluble) and Senecionine N-oxide (water soluble) were examined using the CHEST method (Chick Embryotoxicity Screening Test). The beginning of the embryotoxicity range for senecionine was found to be between 3-30 micrograms; Senecionine N-oxide, on the other hand, showed no effect even with 100 micrograms dose.
CONCLUSIONS:
On the basis of the theoretical calculation, it can be expected that senecionine embryotoxicity for mammals ranges between 10-100 mg/kg maternal body weight, overlapping in this way the known adult toxicity range. The rat LD50 of most alkaloids known to be significant for human health are in the range of 34-300 mg/kg.

Senecionine N-oxide Description

Source:	The roots of Senecio vulgaris L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Senecionine N-oxide
Price:	$268 / 5mg
CAS No.:	13268-67-2
Catalog No.:	CFN00418
Molecular Formula:	C₁₈H₂₅NO₆
Molecular Weight:	351.17 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The roots of Senecio vulgaris L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Hepatotoxicity Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8476 mL	14.2381 mL	28.4762 mL	56.9525 mL	71.1906 mL
5 mM	0.5695 mL	2.8476 mL	5.6952 mL	11.3905 mL	14.2381 mL
10 mM	0.2848 mL	1.4238 mL	2.8476 mL	5.6952 mL	7.1191 mL
50 mM	0.057 mL	0.2848 mL	0.5695 mL	1.139 mL	1.4238 mL
100 mM	0.0285 mL	0.1424 mL	0.2848 mL	0.5695 mL	0.7119 mL

CFN00424	Senkirkine	2318-18-5	365.42	C₁₉H₂₇NO₆
CFN98618	Seneciphylline N-oxide	38710-26-8	349.4	C₁₈H₂₃NO₆
CFN98747	Seneciphylline	480-81-9	333.4	C₁₈H₂₃NO₅
CFN00363	Crotafoline	38494-87-0	351.40	C₁₈H₂₅NO₆
CFN00378	Ligularine	34429-54-4	381.4	C₁₉H₂₇NO₇
CFN00408	Isatidine	15503-86-3	367.40	C₁₈H₂₅NO₇
CFN00418	Senecionine N-oxide	13268-67-2	351.17	C₁₈H₂₅NO₆
CFN00420	Seneciphyllinine	90341-45-0	375.42	C₂₀H₂₅NO₆
CFN00421	Riddelline	23246-96-0	349.38	C₁₈H₂₃NO₆
CFN00469	Riddelline N-oxide	75056-11-0	365.4	C₁₈H₂₃NO₇