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Shizukaol C
Shizukaol C
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Shizukaol C
Price:
CAS No.: 142279-41-2
Catalog No.: CFN99461
Molecular Formula: C36H42O10
Molecular Weight: 634.7 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Powder
Source: The herbs of Chloranthus japonicus
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 1. Shizukaol C shows anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains.
2. Shizukaol C has significant cytotoxicities against C8166 cells.
Targets: HIV | Antifection
Shizukaol C Description
Source: The herbs of Chloranthus japonicus
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.5755 mL 7.8777 mL 15.7555 mL 31.511 mL 39.3887 mL
5 mM 0.3151 mL 1.5755 mL 3.1511 mL 6.3022 mL 7.8777 mL
10 mM 0.1576 mL 0.7878 mL 1.5755 mL 3.1511 mL 3.9389 mL
50 mM 0.0315 mL 0.1576 mL 0.3151 mL 0.6302 mL 0.7878 mL
100 mM 0.0158 mL 0.0788 mL 0.1576 mL 0.3151 mL 0.3939 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Shizukaol C References Information
Citation [1]

J Nat Prod. 2011 Jun 24;74(6):1408-13.

Lindenane disesquiterpenoids with anti-HIV-1 activity from Chloranthus japonicus.[Pubmed: 21650224 ]
Five new lindenane disesquiterpenoids, chlorajaponilides A-E (1-5), together with 11 known analogues were isolated from whole plants of Chloranthus japonicus. The structure and absolute configuration of 1 was confirmed by X-ray crystallography. Compounds 1 and 2 represent the first examples of lindenane disesquiterpenoids with a C-5 hydroxy group and a C-4-C-15 double bond. Compounds 8, 9(Shizukaol C), 11, and 12 showed anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains. Shizukaol B (8) exhibited the best activity against HIV(wt), HIV(RT-K103N), and HIV(RT-K103N) with EC₅₀ values of 0.22, 0.47, and 0.50 μM, respectively. Compounds 8, 9(Shizukaol C), 11, and 12 had significant cytotoxicities against C8166 cells with CC₅₀ values of 0.020, 0.089, 0.047, and 0.022, respectively, and exhibited inhibitory activities against HIV-1 with EC₅₀ values of 0.0014, 0.016, 0.0043, and 0.0033 μM, respectively.
7-Epitaxol

Catalog No: CFN90371
CAS No: 105454-04-4
Price: $60/20mg
Cauloside A

Catalog No: CFN96440
CAS No: 17184-21-3
Price: $318/10mg
Meloside A

Catalog No: CFN90132
CAS No: 60767-80-8
Price: $238/5mg
2-Amino-3-carboxy-1,4-naphthoquinone

Catalog No: CFN91040
CAS No: 173043-38-4
Price: $388/5mg
Sagittatoside A

Catalog No: CFN90139
CAS No: 118525-35-2
Price: $318/5mg
alpha-Carotene

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L-Leucine

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Juglanin

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Coixol

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Shikonin

Catalog No: CFN99907
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Price: $50/20mg
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