• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Natural Products
    Sibiricose A6
    Information
    CAS No. 241125-75-7 Price $258 / 20mg
    Catalog No.CFN90646Purity>=98%
    Molecular Weight548.5Type of CompoundPhenylpropanoids
    FormulaC23H32O15Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    Our products had been exported to the following research institutions and universities, And still growing.
  • University of Hull (United Kingdom)
  • Rio de Janeiro State University (Brazil)
  • Nanjing University of Chinese Me... (China)
  • University of Stirling (United Kingdom)
  • Chinese University of Hong Kong (China)
  • Subang Jaya Medical Centre (Malaysia)
  • Molecular Biology Institute of B... (Spain)
  • Melbourne University (Australia)
  • Calcutta University (India)
  • Mahidol University (Thailand)
  • University of Wuerzburg (Germany)
  • More...
  • Package
    Featured Products
    Terrestrosin K

    Catalog No: CFN90822
    CAS No: 193605-07-1
    Price: $268/10mg
    Schaftoside

    Catalog No: CFN90197
    CAS No: 51938-32-0
    Price: $100/20mg
    Isochlorogenic acid A

    Catalog No: CFN99118
    CAS No: 2450-53-5
    Price: $108/20mg
    Enmein

    Catalog No: CFN92435
    CAS No: 3776-39-4
    Price: $433/5mg
    Kushenol C

    Catalog No: CFN92391
    CAS No: 99119-73-0
    Price: $468/10mg
    Biological Activity
    Description: Sibiricose A6 displays antidepressant-like action, it may prevent or relieve depression; it also shows potent antioxidant activity.
    In vitro:
    《China Journal of Chinese Materia Medica》 2008-11
    Study on antidepressant components of sucrose ester from Polygala tenuifolia[Reference: WebLink]
    To investigate the antidepressant components of Polygala tenuifolia.
    METHODS AND RESULTS:
    The chromatographic method was used to isolate and purify the chemical constituents,their structures were identified by spectral analysis,MTT method was applied to investigate their cytotoxic activities. Nine compounds were isolated from the roots of P.tenuifolia.Their structures were identified as sibiricose A1(1),sibiricose A5(2),tenuifoliside A(3) and 3′,6-disinapoyl sucrose(4),Sibiricose A6(5),3,4,5-trimethoxycinnamate(6),polygalaxanthone Ⅲ(7),tenuifolioses A(8),tenuifolioses H(9) and some compounds' activities to PC12 were observed.
    CONCLUSIONS:
    Compound1 was isolated from this plant for the first time.Compounds 2,3 could protect PC12 cells damage induced by P.tenuifolia.
    Talanta. 2015 Nov 1;144:830-5.
    Indirect identification of antioxidants in Polygalae Radix through their reaction with 2,2-diphenyl-1-picrylhydrazyl and subsequent HPLC-ESI-Q-TOF-MS/MS.[Pubmed: 26452897]
    A rapid and efficient method for the identification of antioxidants in the traditional Chinese medicine Polygalae Radix (PR) by HPLC-ESI-Q-TOF-MS/MS is described.
    METHODS AND RESULTS:
    The method is based on the hypothesis that upon reaction of antioxidants with 1,1-diphenyl-2-picrylhydrazyl (DPPH), the peak areas of compounds with potential antioxidant activities in the HPLC chromatogram will be significantly reduced in comparison to the untreated sample. The identity confirmation was achieved by Q-TOF-MS/MS technique. With this method, eight components were proposed possessing potent antioxidant activity. They were identified as sibiricose A5, Sibiricose A6, sucrose monoester, polygalaxanthone III, tenuifoliside B, 3',6-disinapoylsucrose (DISS), sucrose diester, tenuifoliside C, respectively. DISS was proposed to be the most potent one. The antioxidant activity of DISS was evaluated by DPPH, ABTS radical scavenging assay and ferric-reducing antioxidant power (FRAP) assay in vitro. Vitamin C (Vc) was used as positive control substance. DISS showed moderate DPPH (DISS's IC50 value was 1024.17 μg/mL, Vc's was 294.68 μg/mL) and ABTS (IC50 324.13 μg/mL, Vc's was 117.50 μg/mL) free radical scavenging capacity and ferric-reducing antioxidant power.
    CONCLUSIONS:
    DISS can be used as a new source of natural antioxidant in foods and cosmetics.
    In vivo:
    Molecules. 2011 Jun 29;16(7):5507-13.
    Absorbable phenylpropenoyl sucroses from Polygala tenuifolia.[Pubmed: 21716172]

    METHODS AND RESULTS:
    Three phenylpropenoyl sucroses--Sibiricose A5, Sibiricose A6 and 3',6-disinapoyl sucrose--were isolated from the 30% EtOH extract of Polygala tenuifolia, which displayed antidepressant-like action.
    CONCLUSIONS:
    HPLC analysis indicated that the three phenylpropenoyl sucroses could be absorbed into serum. From the serum pharmacochemistry point of view, these three phenylpropenoyl sucroses might prevent or relieve depression.
    Sibiricose A6 Description
    Source: The roots of Polygala tenuifolia.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recent ChemFaces New Products and Compounds
    Ginsenoside Rk2

    Catalog No: CFN92818
    CAS No: 364779-14-6
    Price: $498/10mg
    Calycosin-7-O-beta-D-glucoside

    Catalog No: CFN99141
    CAS No: 20633-67-4
    Price: $128/20mg
    Macrophylloside D

    Catalog No: CFN95113
    CAS No: 179457-69-3
    Price: $318/10mg
    Pinoresinol

    Catalog No: CFN98775
    CAS No: 487-36-5
    Price: $268/20mg
    Coelonin

    Catalog No: CFN92693
    CAS No: 82344-82-9
    Price: $388/5mg
    Secoxyloganin

    Catalog No: CFN98996
    CAS No: 58822-47-2
    Price: $158/20mg
    Polyporenic acid C

    Catalog No: CFN92739
    CAS No: 465-18-9
    Price: $333/5mg
    Ganoderic acid DM

    Catalog No: CFN99815
    CAS No: 173075-45-1
    Price: $592/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8232 mL 9.1158 mL 18.2315 mL 36.4631 mL 45.5789 mL
    5 mM 0.3646 mL 1.8232 mL 3.6463 mL 7.2926 mL 9.1158 mL
    10 mM 0.1823 mL 0.9116 mL 1.8232 mL 3.6463 mL 4.5579 mL
    50 mM 0.0365 mL 0.1823 mL 0.3646 mL 0.7293 mL 0.9116 mL
    100 mM 0.0182 mL 0.0912 mL 0.1823 mL 0.3646 mL 0.4558 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.