Soyasapogenol A | CAS:508-01-0 | Manufacturer ChemFaces

Soyasapogenol A

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Isoferulic acid

Catalog No: CFN98282
CAS No: 25522-33-2
Price: $50/20mg

Caffeoyl alcohol

Catalog No: CFN70348
CAS No: 3598-26-3
Price: $318/10mg

Neogambogic acid

Catalog No: CFN90175
CAS No: 93772-31-7
Price: $258/20mg

Neochamaejasmine A

Catalog No: CFN92151
CAS No: 90411-13-5
Price: $418/5mg

Taurine

Catalog No: CFN00020
CAS No: 107-35-7
Price: $ /

Ajugol

Catalog No: CFN90759
CAS No: 52949-83-4
Price: $80/20mg

Beta-Carotene

Catalog No: CFN98117
CAS No: 7235-40-7
Price: $40/20mg

Sodium Danshensu

Catalog No: CFN99163
CAS No: 67920-52-9
Price: $40/20mg

Jujuboside A

Catalog No: CFN98101
CAS No: 55466-04-1
Price: $70/20mg

Beta-mangostin

Catalog No: CFN99723
CAS No: 20931-37-7
Price: $218/10mg

Description:

Soyasapogenol A shows estrogenic and hepatoprotective activities, it directly prevents apoptosis of hepatocytes, and secondly, inhibits the elevation of plasma TNF-α, which consequently resulted in the prevention of liver damage in the concanavalin A-induced hepatitis model.

Targets:

TNF-α

In vitro:

J Agric Food Chem. 2008 Apr 23;56(8):2603-8.

Effect of soyasapogenol A and soyasapogenol B concentrated extracts on HEP-G2 cell proliferation and apoptosis.[Pubmed: 18361499 ]

METHODS AND RESULTS:
The growth inhibition and the induction of apoptosis brought about by soyasaponins extracted from soy flour ( Glycine max (L.)) and concentrated for soyasapogenols A and B formed by hydrolysis were tested for cytoactivity in the human hepatocellular carcinoma cell line Hep-G2. Concentrated Soyasapogenol A (SG-A) and soyasapogenol B (SG-B) extracts contained approximately 69.3% and 46.2% of their respective aglycones (soyasapogenols) assessed by HPLC and ESI-MS, while the soyasaponin extract (TS), derived from crude methanol extraction, did not contain any detectable amounts of SG-A or SG-B. An MTT viability assay showed that all three extracts had an effect on Hep-G2 proliferation in a dose-response manner with 72 h LC50 values of 0.594+/-0.021 mg/mL for TS, 0.052+/-0.011 mg/mL for SG-A, and 0.128+/-0.005 mg/mL for SG-B. Apoptotic cells were determined by flow cytometry cell cycle analysis and confocal laser scanning microscopy (CLSM). Cell cycle analysis indicated a significant ( P< 0.05) greater sub-G1 buildup of apoptotic cells at 24 h (25.63+/-2.1%) and 72 h (47.1+/-3.5%) for the SG-A extract compared to SG-B, whereas the TS extract produced only a minor buildup of sub-G1 cells. CLSM confirmed a morphological change of all treatments after 24 h, at the respective LC50 concentrations.
CONCLUSIONS:
These results show that the samples that contained mainly soyasapogenols A and B showed a greater ability to inhibit proliferation of cultured Hep-G2 when compared to a total soyasaponin extract that did not contain any soyasapogenols.

In vivo:

Eur J Pharmacol. 2000 Mar 10;391(1-2):175-81.

Protective effects of soyasapogenol A on liver injury mediated by immune response in a concanavalin A-induced hepatitis model.[Pubmed: 10720649]

The present study was carried out to analyze the effects of Soyasapogenol A on the liver injury mediated by the immune response in concanavalin A-induced hepatitis in mice.
METHODS AND RESULTS:
Soyasapogenol A reduced the number of infiltrating inflammatory cells in the liver and significantly lowered the elevated level of plasma tumor necrosis factor-alpha (TNF-alpha) 2 h after concanavalin A treatment, and then markedly reduced the elevated plasma alanine aminotransferase activity and decreased the number of apoptotic bodies in the liver parenchymal cells but not in the sinusoidal cells at 24 h.
CONCLUSIONS:
Since the effect of Soyasapogenol A on the elevated plasma TNF-alpha level was not appreciable compared to the preventive effect of Soyasapogenol A on the elevated plasma alanine aminotransferase level, these results suggest that Soyasapogenol A directly prevents apoptosis of hepatocytes, and secondly, inhibits the elevation of plasma TNF-alpha, which consequently resulted in the prevention of liver damage in the concanavalin A-induced hepatitis model.

Soyasapogenol A Description

Source:	The seeds of Glycine max
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Cell Research:

Food Chem Toxicol. 2002 Dec;40(12):1767-74.

Estrogenic and antiproliferative properties of soy sapogenols in human breast cancer cells in vitro.[Pubmed: 12419690]

Two soy sapogenols, Soyasapogenol A (SA) and soyasapogenol B (SB) were tested for their estrogenic activities in estrogen responsive MCF-7 or estrogen-insensitive MDA-MB-231 (MDA) human breast cancer cells.
CONCLUSIONS:
SB and SA had differential actives on cell proliferation with 10 microM SB being growth inhibitory to MDA cells with no significant effect at any concentration on MCF-7 cells. SA also inhibited MDA cell proliferation at 10 micro, but at this same dose stimulated a 2.5-fold increase in MCF-7 proliferation. SA (0.1-10 microM) induced pS2 mRNA levels and the induction was blocked by co-treatment of cells with the anti-estrogen ICI 182,780. SA also induced the formation of an ER-ERE DNA complex measured by electrophoretic mobility shift assay.
CONCLUSIONS:
In summary, these results show that Soyasapogenol A is estrogenic, whereas soyasapogenol B is growth inhibitory.

Product Name	Soyasapogenol A
Price:
CAS No.:	508-01-0
Catalog No.:	CFN93150
Molecular Formula:	C₃₀H₅₀O₄
Molecular Weight:	474.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The seeds of Glycine max
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Hepatoprotective Compound Library Anti-proliferation Compound Library Estrogenic effect Compound Library Triterpenoids Compound Library TNF-α Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1066 mL	10.533 mL	21.0659 mL	42.1319 mL	52.6648 mL
5 mM	0.4213 mL	2.1066 mL	4.2132 mL	8.4264 mL	10.533 mL
10 mM	0.2107 mL	1.0533 mL	2.1066 mL	4.2132 mL	5.2665 mL
50 mM	0.0421 mL	0.2107 mL	0.4213 mL	0.8426 mL	1.0533 mL
100 mM	0.0211 mL	0.1053 mL	0.2107 mL	0.4213 mL	0.5266 mL

CFN99679	beta-Amyrin acetate	1616-93-9	468.8	C₃₂H₅₂O₂
CFN97009	beta-Amyrin palmitate	5973-06-8	665.1	C₄₆H₈₀O₂
CFN97099	beta-Amyrone	638-97-1	424.7	C₃₀H₄₈O
CFN97528	9(11),12-Oleanadien-3-ol	94530-87-7	424.7	C₃₀H₄₈O
CFN94009	12-Oleanene-3,6-diol	41498-79-7	442.72	C₃₀H₅₀O₂
CFN94010	Daturaolone	41498-80-0	440.71	C₃₀H₄₈O₂
CFN96835	Rubiprasin B	125263-66-3	500.76	C₃₂H₅₂O₄
CFN96836	Rubiprasin A	125263-65-2	516.76	C₃₂H₅₂O₅
CFN98801	13(18)-Oleanen-3-ol	508-04-3	426.7	C₃₀H₅₀O
CFN98820	delta-Amyrin acetate	51361-60-5	468.8	C₃₂H₅₂O₂