Spectabiline | CAS:520-55-8 | Manufacturer ChemFaces

Spectabiline

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Spectabiline shows tumor-inhibitory properties against one or more test tumors. Spectabiline, monocrotaline, sarracine, lasiocarpine, 7-angelylheliotridine, heliotrine and senecionine have similar antagonistic potencies against responses to both acetylcholine and histamine.

Targets:

AChR | Histamine Receptor

In vitro:

Br J Pharmacol. 1971 Apr;41(4):683-90.

Pyrrolizidine alkaloids: actions on muscarinic receptors in the guinea-pig ileum.[Pubmed: 5579465]

METHODS AND RESULTS:
1. Eleven pyrrolizidine alkaloids have been tested on the isolated guinea-pig ileum preparation.2. Platyphylline, supinine, heleurine and cynaustraline were more potent in antagonizing responses to acetylcholine and carbachol than responses to histamine. Their anticholinergic activity appeared to involve a competitive mechanism.3. Lasiocarpine, monocrotaline, Spectabiline, sarracine, 7-angelylheliotridine, heliotrine and senecionine had similar antagonistic potencies against responses to both acetylcholine and histamine.
CONCLUSIONS:
4. The alkaloids had no appreciable activity as antagonists of acetylcholine in the isolated toad rectus abdominis preparation.5. These results are discussed with respect to interactions of the alkaloids at receptor sites involved in anticholinergic activity at the muscarinic receptor.

J Pharm Sci. 1968 Jul;57(7):1112-7.

Tumor-inhibitory activity of pyrrolizidine alkaloids[Reference: WebLink]

METHODS AND RESULTS:
Eighteen pyrrolizidine alkaloids and several derivatives have been examined for tumor-inhibitory properties. Of these, 10 compounds show significant activity against one or more test tumors. Heliotrine, lasiocarpine, monocrotaline, Spectabiline, and senecionine are highly active against the Walker 256 (intramuscular) system.
CONCLUSIONS:
The activity pattern is consistent with the tumor-inhibitory action being associated with the allylic ester function which imparts alkylating ability and is also responsible for hepatotoxicity.

Spectabiline Description

Source:	The herbs of Crotalaria spectabilis Roth
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Spectabiline
Price:
CAS No.:	520-55-8
Catalog No.:	CFN00386
Molecular Formula:	C₁₈H₂₅NO₇
Molecular Weight:	367.40 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Crotalaria spectabilis Roth
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Anticholinesterase Compound Library Alkaloids Compound Library Histamine Receptor Inhibitor Library AChR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7218 mL	13.6091 mL	27.2183 mL	54.4366 mL	68.0457 mL
5 mM	0.5444 mL	2.7218 mL	5.4437 mL	10.8873 mL	13.6091 mL
10 mM	0.2722 mL	1.3609 mL	2.7218 mL	5.4437 mL	6.8046 mL
50 mM	0.0544 mL	0.2722 mL	0.5444 mL	1.0887 mL	1.3609 mL
100 mM	0.0272 mL	0.1361 mL	0.2722 mL	0.5444 mL	0.6805 mL

CFN00431	Swazine	38763-74-5	349.38	C₁₈H₂₃NO₆
CFN00437	Antibiotic PF 1018	131256-42-3	433.59	C₂₈H₃₅NO₃
CFN00362	Crosemperine	30785-56-9	367.44	C₁₉H₂₉NO₆
CFN00364	Crotalarine	53937-97-6	353.41	C₁₈H₂₇NO₆
CFN00369	Erucifoline	40158-95-0	349.38	C₁₈H₂₃NO₆
CFN00453	Erucifolin N-oxide	123864-94-8	365.4	C₁₈H₂₃NO₇
CFN00375	Jacobine	6870-67-3	351.40	C₁₈H₂₅NO₆
CFN00461	Jacobine N-oxide	38710-25-7	367.4	C₁₈H₂₅NO₇
CFN00380	Madurensine	26126-78-3	351.40	C₁₈H₂₅NO₆
CFN00382	Spiranine	77156-23-1	469.53	C₂₃H₃₅NO₉