| In vitro: |
| Wei Sheng Yan Jiu. 2002 Apr;31(2):112-4. | | Effects of sterigmatocystin on interleukin-2 secretion of human peripheral blood mononuclear cells in vitro.[Pubmed: 12561545] |
Sterigmatocystin (ST) is one of predominant contaminating mycotoxins in foodstuffs and grains of high incidence areas of malignant tumors in China.
METHODS AND RESULTS:
The effect of ST on interleukin-2 (IL-2) secretion of human peripheral blood mononuclear cells (HPBMc) in vitro was determined with enzyme-linked immunosorbent assay (ELISA) method to explore its putative effects on human immune function. ELISA analysis revealed that ST treatment generally showed negative effects on the IL-2 secretion of HPBMc in vitro. As the ST concentration changes, the inhibiting effects were different. The inhibiting effects at low concentrations (0.03125-0.125 mg/L) and high concentrations (1-2 mg/L) were stronger than the other concentrations(P < 0.05). The time-effect analysis (ST 1 mg/L) showed that inhibiting effects of ST on IL-2 secretion of HPBMc could be seen to a variable degree from 1 to 64 h after ST treatment, while a significant time-effect correlation could be found from 8 to 64 h (r = 0.822, P < 0.05).
CONCLUSIONS:
The results obtained in present study showed that ST has certain inhibiting effects on the secretion of IL-2 of HPBMc in vitro. | | Mol Nutr Food Res. 2010 Jan;54(1):136-47. | | Sterigmatocystin: occurrence in foodstuffs and analytical methods--an overview.[Pubmed: 19998385] |
METHODS AND RESULTS:
Sterigmatocystin (STC) is a mycotoxin produced by fungi of many different Aspergillus species. Other species such as Bipolaris, Chaetomium, Emiricella are also able to produce STC. STC producing fungi were frequently isolated from different foodstuffs, while STC was regularly detected in grains, corn, bread, cheese, spices, coffee beans, soybeans, pistachio nuts, animal feed and silage. STC shows different toxicological, mutagenic and carcinogenic effects in animals and has been recognized as a 2B carcinogen (possible human carcinogen) by International Agency for Research on Cancer. There are more than 775 publications available in Scopus (and more than 505 in PubMed) mentioning STC, but there is no summary information available about STC occurrence and analysis in food.
CONCLUSIONS:
This review presents an overview of the worldwide information on the occurrence of STC in different foodstuffs during the last 40 years, and describes the progress made in analytical methodology for the determination of STC in food. |
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