| Description: |
Taxiresinol shows anticancer, antinociceptive, and antiallergic activities, it shows inhibitory activity on induced histamine release from the human basophilic cell line, KU812. Taxiresinol can protect the hepatocytes from apoptosis via an inhibition of TNF- alpha production by activated macrophages and a direct inhibition of apoptosis induced by TNF- alpha in D-GalN/LPS-treated mice. |
| Targets: |
TNF-α | Immunology & Inflammation related |
| In vitro: |
| Bioorg Med Chem. 2003 Nov 17;11(23):4945-8. | | Absolute configuration and anticancer activity of taxiresinol and related lignans of Taxus wallichiana.[Pubmed: 14604656] |
METHODS AND RESULTS:
Absolute configuration of Taxiresinol 1, a lignan from the heartwood of Taxus wallichiana has been determined as 8R, 8'R, and 7'R with the help of chemical correlation method and X-ray crystallography. The anticancer activity of Taxiresinol 1 and other two lignans 2, 3 were also studied.
CONCLUSIONS:
Taxiresinol 1 showed notable anticancer activity in the in vitro bioassays against colon, liver, ovarian and breast cancer cell lines. | | Biol Pharm Bull. 2006 Nov;29(11):2310-2. | | Antiallergic activity of aqueous extracts and constituents of Taxus yunnanensis.[Pubmed: 17077536] | The H2O, H2O/MeOH (1:1) extracts from the wood of Taxus yunnanensis showed a remarkable inhibitory effect on induced histamine release from the human basophilic cell line, KU812.
METHODS AND RESULTS:
The eleven constituents purified from the wood extracts of Taxus yunnanensis were tested by an in vitro histamine release inhibition assay. Among them, secoisolarciresinol and Taxiresinol were found to show inhibitory activities.
CONCLUSIONS:
A new neolignan, 2-[2-hydroxy-5-(3-hydroxypropyl)-3-methoxyphenyl]-1-(4-hydroxy-3-methoxyphenyl)propane-1,3-diol, was isolated from the wood of Taxus yunnanensis. |
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| In vivo: |
| J Ethnopharmacol. 2003 Dec;89(2-3):265-70. | | Anti-inflammatory and antinociceptive activity of taxoids and lignans from the heartwood of Taxus baccata L.[Pubmed: 14611890] |
METHODS AND RESULTS:
Four taxoids (taxusin, baccatin VI, baccatin III and 1beta-hydroxybaccatin I) and five lignans (lariciresinol, Taxiresinol, 3'-demethylisolariciresinol-9'-hydroxyisopropylether, isolariciresinol and 3-demethylisolariciresinol) were isolated from the heartwood of Taxus baccata L. (Taxaceae) growing in Turkey through chromatographic techniques. In vivo anti-inflammatory and antinociceptive activity of these compounds were investigated.
CONCLUSIONS:
All the compounds were shown to possess significant antinociceptive activity against p-benzoquinone-induced abdominal contractions, while only lignan derivatives significantly inhibited carrageenan-induced hind paw edema in mice. |
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