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Trigoxyphin A
Trigoxyphin A
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Product Name Trigoxyphin A
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CAS No.: 1236874-00-2
Catalog No.: CFN96564
Molecular Formula: C34H34O9
Molecular Weight: 586.63 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The twigs of Trigonostemon xyphophylloides.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Trigoxyphin A exhibits strong cytotoxic activity against HL60 (IC(50): 0.27 microM) and A549 (IC(50): 7.5 microM) tumor cell lines.
In vitro:
J Nat Prod. 2010 Jul 23;73(7):1301-5.
Trigoxyphins A-G: diterpenes from Trigonostemon xyphophylloides.[Pubmed: 20593838]

METHODS AND RESULTS:
Six new oxygenated daphnane-type diterpenoids, trigoxyphins A-F (1-6), a phenanthrene-type diterpenoid, trigoxyphin G (7), and two known compounds were isolated from twigs of Trigonostemon xyphophylloides. Their structures were established using spectroscopic methods.
CONCLUSIONS:
Compounds Trigoxyphin A (1) and trigoxyphin B (2) exhibited strong cytotoxic activity against HL60 (IC(50): 0.27 and 0.49 microM) and A549 (IC(50): 7.5 and 4.9 microM) tumor cell lines, respectively.
Trigoxyphin A Description
Source: The twigs of Trigonostemon xyphophylloides.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7047 mL 8.5233 mL 17.0465 mL 34.093 mL 42.6163 mL
5 mM 0.3409 mL 1.7047 mL 3.4093 mL 6.8186 mL 8.5233 mL
10 mM 0.1705 mL 0.8523 mL 1.7047 mL 3.4093 mL 4.2616 mL
50 mM 0.0341 mL 0.1705 mL 0.3409 mL 0.6819 mL 0.8523 mL
100 mM 0.017 mL 0.0852 mL 0.1705 mL 0.3409 mL 0.4262 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN893927,13-Dideacetyl-9,10-didebenzoyltaxchinin C156497-25-5546.60C29H38O10
CFN893999-Deacetyl-9-benzoyl-10-debenzoyl-4beta,20-epoxytaxchinin A227011-48-5588.64C31H40O11
CFN893939-Deacetyl-9-benzoyl-10-debenzoyltaxchinin A172486-22-5572.64C31H40O10
CFN96629Taxuspine W181309-92-2492.57C26H36O9
CFN96637Taxin B168109-52-2534.60C28H38O10
CFN969032alpha,7beta,13alpha-Triacetoxy-5alpha-cinnamoyloxy-9beta-hydroxy-2(3->20)abeotaxa-4(20),11-dien-10-one322471-42-1622.71C35H42O10
CFN96630Taxuspine B157414-05-6622.71C35H42O10
CFN980565,8,9,10,14-Pentaacetoxy-3-benzoyloxy-15-hydroxypepluane210108-91-1700.8 C37H48O13
CFN893795,8,9,14-Tetraacetoxy-3-benzoyloxy-10,15-dihydroxypepluane219916-77-5658.73C35H46O12
CFN96564Trigoxyphin A1236874-00-2586.63C34H34O9
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