ChemFaces is a professional high-purity natural products manufacturer.
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2. Pharmacological research
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More articles cited ChemFaces products.
J Chromatogr Sci.2015 Feb 5. pii: bmu231. J Sep Sci.2018 Jan 23.Journal of Agricultural Science2015 Sep 15Anal Bioanal Chem.2018 Feb;Food Research InternationalApr. 2018;
Cell11 Jan. 2018;Front Pharmacol. 2016 Nov 30Academic JournalApr. 2014Journal of Pharmaceutical Analysis2016 Dec.Acta Biochim Pol.2015 May 26
Faculty of Chem. & Nat. Resource Eng.Jul. 2014Universite de Bordeaux15 Dec 2017;J of L. Chroma. & Related Tech2017 Apr 21;Univ. of Limpopo2016
Our products had been exported to the following research institutions and universities, And still growing.
University of Hull (United Kingdom)Center for protein Engineering (... (Belgium)Institute of Pathophysiology Med... (Austria)Weizmann Institute of Science (Israel)
University of Queensland (Australia)University of Dicle (Turkey)University of Amsterdam (Netherlands)University of Toulouse (France)
Universidad Industrial de Santan... (Colombia)Sanford Burnham Medical Research... (USA)Universite Libre de Bruxelles (Belgium)
||Tryptophol is an aromatic alcohol found as a secondary product of alcoholic fermentation that induces sleep in humans. Tryptophol can inhibit the infection/replication of GVE2 by interacting with the host's Clp protease. Tryptophol can inhibit the proliferation of U937 cells by inducing apoptosis via a pathway involving caspase-8 followed by caspase-3. Tryptophol induces apoptosis through Death Receptor (DR) 5 and that the resistance of peripheral blood lymphocytes (PBL) to tryptophol-induced apoptosis might be due to competition from decoy receptor (DcR).|
||PARP | Caspase|
|Biosci Biotechnol Biochem. 2007 Aug;71(8):2065-8. |
|Tryptophol induces death receptor (DR) 5-mediated apoptosis in U937 cells.[Pubmed: 17690453]|
|Tryptophol is a natural component isolated from vinegar produced from the boiled extract of black soybean. We have reported that Tryptophol induces apoptosis in U937 cells via activation of caspase-8 followed by caspase-3. Tryptophol, however, did not affect human peripheral blood lymphocytes (PBL). |
METHODS AND RESULTS:
In this study, we found that Tryptophol enhances formation of a death-inducing signaling complex including death receptor (DR) 5. Cell viability and induction of apoptosis by Tryptophol was reduced by transfection with decoy receptor (DcR) 1.
These results indicate that Tryptophol induces apoptosis through DR5 and that the resistance of PBL to Tryptophol-induced apoptosis might be due to competition from DcR1.
|Basic Clin Pharmacol Toxicol. 2008 May;102(5):443-52. |
|Genotoxicity of tryptophol in a battery of short-term assays on human white blood cells in vitro.[Pubmed: 18248512]|
METHODS AND RESULTS:
The genotoxic effects of Tryptophol (indole-3-ethanol), an aromatic alcohol and known secondary metabolite of the opportunistic yeast Candida albicans and other Candida spp. The results obtained suggest cytotoxic, cytostatic and genotoxic effects of the Tryptophol treatment in vitro that were mainly dose-dependent. The type and the extent of DNA lesions detected in Tryptophol-treated samples indicate the possibility that observed damage is mediated by highly reactive aldehyde metabolite and/or free radicals produced by treatment. The results show that mortality of lymphocytes in Tryptophol-treated samples was primarily caused by apoptosis. The generation of additional DNA strand breaks and cytogenetic consequences (chromosome aberrations, sister chromatid exchanges and micronuclei), as observed in this study, sustain the possibility that Tryptophol toxicity is mediated by the formation of DNA cross-links and aldehyde-protein adducts.
In conclusion, this preliminary study elucidates only a part of Tryptophol toxicity to human cells. Because current evidence is not sufficient to obtain information relevant for human risk assessment, further in vitro and in vivo studies are essential in order to clarify remaining issues, especially to elucidate the exact mechanisms and nature of the damage produced following treatment as well to estimate possible interindividual variability in genotoxic responses to the chemical.
|Experientia. 1976 May 15;32(5):645-7. |
|The effects of tryptophol on immune responses and it implications toward trypanosome-induced immunosuppression.[Pubmed: 776647]|
METHODS AND RESULTS:
Daily administration of Tryptophol to laboratory rodents resulted in significantly depressed antibody production of heterologous red blood cell challenge, did not alter cellular-mediated responses to oxazalone.
These results suggest that trypanosome-produced Tryptophol may account for the immunodepression observed during trypanosomiasis.
|Life Sci. 1970 Mar 15;9(6):323-9. |
|Tryptophol, 5-hydroxytryptophol and 5-methoxytryptophol induced sleep in mice.[Reference: WebLink]|
METHODS AND RESULTS:
Tryptophol, 5-hydroxyTryptophol and 5-methoxyTryptophol were found to induce sleep in mice. The onset of action was most rapid for Tryptophol and 5-methoxyTryptophol; 5-hydroxyTryptophol had the slowest onset, probably due to difficulty of transport across the blood-brain barrier. Sleep times were shortest for Tryptophol and 5-methoxyTryptophol and longest for 5-hydroxyTryptophol.
It was suggested that the Tryptophols or the corresponding aldehydes may play a role in physiological sleep mechanisms.
||From Zygosaccharomyces priorianus.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Biosci Biotechnol Biochem. 2007 Feb;71(2):371-9. |
|Isolation of tryptophol as an apoptosis-inducing component of vinegar produced from boiled extract of black soybean in human monoblastic leukemia U937 cells.[Pubmed: 17284845]|
|We isolated a novel apoptosis-inducing component, Tryptophol, from vinegar produced from boiled extract of black soybean (black soybean vinegar). |
METHODS AND RESULTS:
Compound-6 purified from an ethyl acetate extract of black soybean vinegar using high performance liquid chromatography (HPLC) induced fragmentation of DNA and the development of apoptotic bodies (characteristic physiological features of apoptosis) in U937 cells. By analysis of chemical structure, this active compound was identified as Tryptophol. Tryptophol induced apoptosis involving caspase-8 and -3 activation, followed by cleavage of poly (ADP-ribose) polymerase (PARP), as shown by measurement of enzyme activity and immunoblot analysis. The cell viability of normal lymphocytes separated from human blood was less affected by Tryptophol, and fragmentation of DNA was not induced in normal lymphocytes.
These results indicate that Tryptophol isolated from black soybean vinegar inhibited the proliferation of U937 cells by inducing apoptosis via a pathway involving caspase-8 followed by caspase-3, without affecting normal lymphocytes.