Science | Nature | Cell | View More
Natural Products
Butanol
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Butanol
Price: $30 / 20mg
CAS No.: 71-36-3
Catalog No.: CFN98128
Molecular Formula: C4H10O
Molecular Weight: 74.12 g/mol
Purity: >=98%
Type of Compound: Miscellaneous
Physical Desc.: Oil
Source: The heart woods of Pinus yunnanensis.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $5.1 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Korea Food Research Institute(K... (Korea)
  • Cancer Research Initatives Foun... (Malaysia)
  • Shanghai Institute of Biochemis... (China)
  • Seoul National University of Sc... (Korea)
  • Universidad de La Salle (Mexico)
  • University of Beira Interior (Portugal)
  • VIT University (India)
  • Weizmann Institute of Science (Israel)
  • The Institute of Cancer Research (United Kingdom)
  • University of Toulouse (France)
  • Michigan State University (USA)
  • More...
Package
Featured Products
20(R)-Ginsenoside Rg3

Catalog No: CFN98170
CAS No: 38243-03-7
Price: $60/20mg
Aristolochic acid A

Catalog No: CFN99505
CAS No: 313-67-7
Price: $80/20mg
Parishin E

Catalog No: CFN93115
CAS No: 952068-57-4
Price: $298/20mg
Luteolin 7-diglucuronide

Catalog No: CFN70468
CAS No: 96400-45-2
Price: $ / mg
Terpineol

Catalog No: CFN92688
CAS No: 98-55-5
Price: $30/20mg
Ginsenoside Compound K

Catalog No: CFN99756
CAS No: 39262-14-1
Price: $30/20mg
3-O-beta-D-Glucopyranosylplatycodi...

Catalog No: CFN90950
CAS No: 38337-25-6
Price: $268/5mg
Celastrol

Catalog No: CFN99198
CAS No: 34157-83-0
Price: $40/20mg
Crocin I

Catalog No: CFN99927
CAS No: 94238-00-3
Price: $100/20mg
Glycitin

Catalog No: CFN99105
CAS No: 40246-10-4
Price: $70/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Tyrosol is a potential hypo-pigmenting agent, it has neuroprotective, antioxidant, anti-hyperglycemia, and anti-allergic inflammatory effects. Tyrosol has cytoprotective effect in I/R-caused myocyte mortality was involved with the mitigation of ROS, prohibition of the activation of ERK, JNK and caspase-8, and elevation of Hsp70 and Bcl-2/Bax ratio.Tyrosol is a quorum-sensing molecule in Candida albicans, it has important implications on the dynamics of growth and morphogenesis in Candida.
Targets: PI3K | Akt | SOD | IkB | NF-kB | Beta Amyloid | Antifection | IKK
In vitro:
Med Mycol. 2014 Nov;52(8):853-61.
Synergistic effect of amphotericin B and tyrosol on biofilm formed by Candida krusei and Candida tropicalis from intrauterine device users.[Pubmed: 25202127]
The presence of intrauterine contraceptive devices (IUDs) provides a solid surface for attachment of microorganisms and an ideal niche for the biofilm to form and flourish. Vaginal candidiasis is often associated with the use of IUDs. Treatment of vaginal candidiasis that develops in connection with IUD use requires their immediate removal.
METHODS AND RESULTS:
Here, we present in vitro evidence to support the use of combination therapy to inhibit Candida biofilm. Twenty-three clinical Candida isolates (10 C. krusei and 13 C. tropicalis) recovered from endocervical swabs obtained from IUD and non-IUD users were assessed for biofilm-formation ability. The rate of isolation of Candida did not differ significantly among IUD and non-IUD users (P = 0.183), but the biofilm-formation ability of isolates differed significantly (P = 0.02). An in vitro biofilm model with the obtained isolates was subjected to treatment with amphotericin B, tyrosol, and a combination of amphotericin B and tyrosol. Inhibition of biofilm by amphotericin B or tyrosol was found to be concentration dependent, with 50% reduction (P < 0.05) at 4 mg/l and 80 μM, respectively.
CONCLUSIONS:
Hence, a combination effect of tyrosol and amphotericin B was studied. Interestingly, approximately 90% reduction in biofilm was observed with use of 80 μM tyrosol combined with 4 mg/l amphotericin B (P < 0.001). This represents a first step in establishing an appropriate antibiofilm therapy when yeasts are present.
Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5048-52.
Tyrosol is a quorum-sensing molecule in Candida albicans.[Pubmed: 15051880 ]
The human fungal pathogen Candida albicans shows a significant lag in growth when diluted into fresh minimal medium.
METHODS AND RESULTS:
This lag is abolished by the addition of conditioned medium from a high-density culture. The active component of conditioned medium is tyrosol, which is released into the medium continuously during growth. Under conditions permissive for germ-tube formation, tyrosol stimulates the formation of these filamentous protrusions. Because germ-tube formation is inhibited by farnesol, another quorum-sensing molecule, this process must be under complex positive and negative control by environmental conditions.
CONCLUSIONS:
The identification of tyrosol as an autoregulatory molecule has important implications on the dynamics of growth and morphogenesis in Candida.
In vivo:
PLoS One. 2015 Jun 11;10(6):e0129829.
Tyrosol Suppresses Allergic Inflammation by Inhibiting the Activation of Phosphoinositide 3-Kinase in Mast Cells.[Pubmed: 26068872]
Allergic diseases such as atopic dermatitis, rhinitis, asthma, and anaphylaxis are attractive research areas. Tyrosol (2-(4-hydroxyphenyl)ethanol) is a polyphenolic compound with diverse biological activities.
METHODS AND RESULTS:
In this study, we investigated whether tyrosol has anti-allergic inflammatory effects. Ovalbumin-induced active systemic anaphylaxis and immunoglobulin E-mediated passive cutaneous anaphylaxis models were used for the immediate-type allergic responses. Oral administration of tyrosol reduced the allergic symptoms of hypothermia and pigmentation in both animal models. Mast cells that secrete allergic mediators are key regulators on allergic inflammation. Tyrosol dose-dependently decreased mast cell degranulation and expression of inflammatory cytokines. Intracellular calcium levels and activation of inhibitor of κB kinase (IKK) regulate cytokine expression and degranulation. Tyrosol blocked calcium influx and phosphorylation of the IKK complex. To define the molecular target for tyrosol, various signaling proteins involved in mast cell activation such as Lyn, Syk, phosphoinositide 3-kinase (PI3K), and Akt were examined. Our results showed that PI3K could be a molecular target for tyrosol in mast cells.
CONCLUSIONS:
Taken together, these findings indicated that tyrosol has anti-allergic inflammatory effects by inhibiting the degranulation of mast cells and expression of inflammatory cytokines; these effects are mediated via PI3K. Therefore, we expect tyrosol become a potential therapeutic candidate for allergic inflammatory disorders.
Butanol Description
Source: The heart woods of Pinus yunnanensis.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Securoside A

Catalog No: CFN95294
CAS No: 107172-40-7
Price: $318/5mg
1-O-Feruloylglucose

Catalog No: CFN95596
CAS No: 64625-37-2
Price: $413/5mg
Schisphenlignan I

Catalog No: CFN95586
CAS No: 1542234-14-9
Price: $318/5mg
Diosmin Impurity 8

Catalog No: CFN95309
CAS No: 28719-21-3
Price: $318/10mg
4-Keto-laurifoline

Catalog No: CFN95594
CAS No: N/A
Price: $318/10mg
Lonicerin

Catalog No: CFN95055
CAS No: 25694-72-8
Price: $168/10mg
Mahuannin J

Catalog No: CFN95533
CAS No: N/A
Price: $318/5mg
Oxytroflavoside F

Catalog No: CFN95489
CAS No: 1391144-85-6
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 13.4916 mL 67.4582 mL 134.9164 mL 269.8327 mL 337.2909 mL
5 mM 2.6983 mL 13.4916 mL 26.9833 mL 53.9665 mL 67.4582 mL
10 mM 1.3492 mL 6.7458 mL 13.4916 mL 26.9833 mL 33.7291 mL
50 mM 0.2698 mL 1.3492 mL 2.6983 mL 5.3967 mL 6.7458 mL
100 mM 0.1349 mL 0.6746 mL 1.3492 mL 2.6983 mL 3.3729 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Int J Mol Sci. 2013 Nov 28;14(12):23420-40.
Tyrosol and its analogues inhibit alpha-melanocyte-stimulating hormone induced melanogenesis.[Pubmed: 24287915]
Tyrosol and its glycoside, salidroside, are active components of Rhodiola rosea, and in our preliminary study we found that Rhodiola rosea extract inhibited melanogenesis. In this study, we examined the effects of Tyrosol and its analogues on melanin synthesis.
METHODS AND RESULTS:
We found that treatment of B16F0 cells to Tyrosol (1), 4-hydroxyphenylacetic acid (5), 3-hydroxyphenylacetic acid (6), 2-hydroxyphenylacetic acid (7), or salidroside (11) resulted in a reduction in melanin content and inhibition of tyrosinase activity as well as its expression. Tyrosol (1), 4-hydroxyphenylacetic acid (5) and 2-hydroxyphenylacetic acid (7) suppressed MC1R expression. Tyrosol (1), 4-hydroxyphenylacetic acid (5), 3-hydroxyphenylacetic acid (6), and 2-hydroxyphenylacetic acid (7) inhibited α-MSH induced TRP-1 expression, but salidroside (11) did not. All the compounds did not affect MITF and TRP-2 expression. Furthermore, we found that the cell viability of Tyrosol (1), 4-hydroxyphenylacetic acid (5), 3-hydroxyphenylacetic acid (6), and 2-hydroxyphenylacetic acid (7) at concentrations below 4 mM and salidroside (11) at concentrations below 0.5 mM were higher than 90%. The compounds exhibited metal-coordinating interactions with copper ion in molecular docking with tyrosinase.
CONCLUSIONS:
Our results suggest that Tyrosol, 4-hydroxyphenylacetic acid, 3-hydroxyphenylacetic acid, 2-hydroxyphenylacetic acid, and salidroside are potential hypopigmenting agents.
Food Chem. 2013 Nov 15;141(2):1147-57.
Tyrosol exerts a protective effect against dopaminergic neuronal cell death in in vitro model of Parkinson's disease.[Pubmed: 23790897]
Experimental evidence suggests that tyrosol [2-(4-hydroxyphenyl)ethanol] exhibits potent protective activities against several pathogeneses.
METHODS AND RESULTS:
In this study, we evaluated the protective effect of tyrosol against 1-methyl-4-phenylpyridinium (MPP(+))-induced CATH.a neuron cell death. Tyrosol dose-dependently protected CATH.a cells from MPP(+)-induced cell death and the protection was more apparent after prolong incubation (48h). The data showed that tyrosol treatment suppressed the reduction of phospho-tyrosine hydroxylase level in CATH.a cells. Further, the compound repressed MPP(+)-induced depletion of mitochondrial membrane potential (Δψm) and thereby maintained intracellular ATP production in the cell. The cellular signalling pathway studies revealed that tyrosol protected CATH.a cells from MPP(+)-induced apoptotic signalling, most likely via activation of PI3K/Akt signalling pathway along with up-regulation of anti-oxidative enzymes (SOD-1 and SOD-2) and DJ-1 protein in the cell.
CONCLUSIONS:
Collectively, present study demonstrates that tyrosol significantly protects dopaminergic neurons from MPP(+)-induced degradation, and reveals potential neuroprotective mechanism of tyrosol.
Cell Research:
Curr Alzheimer Res. 2011 Aug;8(5):543-51.
Tyrosol and hydroxytyrosol, two main components of olive oil, protect N2a cells against amyloid-β-induced toxicity. Involvement of the NF-κB signaling.[Pubmed: 21605049]
Alzheimer's disease (AD) is the most common form of dementia. Recently, a number of epidemiological studies have evidence that some dietary factors such as low antioxidants and vitamins intake could increase the risk of AD. In the opposite, diets rich in unsaturated fatty acids, in polyphenols, vitamins and antioxidants were identified as preventive factors. Several studies have reported that adherence to the Mediterranean diet (MeDi) was associated with a reduction in incident of dementia. The beneficial effect of MeDi may be the result of the association of some individual and non-identified food components and high consumption of olive oil.
METHODS AND RESULTS:
In this study we have investigated the protective effects of two components of olive oil, tyrosol (Tyr) and hydroxytyrosol (OH-Tyr), against Aβ-induced toxicity. In cultured neuroblastoma N2a cells, we found that Aβ(25-35) (100 µg/ml) treatment induced a decrease of glutathione (GSH) and the activation of the transcription factor NF-κB and cell death. Our results demonstrated that the number of cell death decreased when cells were co-treated with Aβ and Tyr or OH-Tyr. However, neither of these phenolic compounds was able to prevent the decrease of GSH induced by H(2)O(2) or Aβ. We found that the increase in the nuclear translocation of the NF-κB subunits after Aβ exposure was attenuated in the presence of Tyr or OH-Tyr.
CONCLUSIONS:
These results identified two individual food components of the MeDi as neuroprotective agent against Aβ and their potential involvement in the beneficial effect of the MeDi for the prevention of AD.
Animal Research:
Chem Biol Interact. 2015 Mar 5;229:44-54.
Tyrosol, a phenolic compound, ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin induced diabetic rats.[Pubmed: 25641191]
The present study was designed to evaluate the effects of tyrosol, a phenolic compound, on the activities of key enzymes of carbohydrate metabolism in the control and streptozotocin-induced diabetic rats.
METHODS AND RESULTS:
Diabetes mellitus was induced in rats by a single intraperitoneal injection of streptozotocin (40 mg/kg body weight). Experimental rats were administered tyrosol 1 ml intra gastrically at the doses of 5, 10 and 20mg/kg body weight and glibenclamide 1 ml at a dose of 600 μg/kg body weight once a day for 45 days. At the end of the experimental period, diabetic control rats exhibited significant (p<0.05) increase in plasma glucose, glycosylated hemoglobin with significant (p<0.05) decrease in plasma insulin, total hemoglobin and body weight. The activities of key enzymes of carbohydrate metabolism such as phosphoenolpyruvate carboxykinase, fructose-1,6-bisphosphatase and glucose-6-phosphatase were significantly (p<0.05) increased and the activities of hexokinase and glucose-6-phosphate dehydrogenase were significantly (p<0.05) decreased in the liver and kidney of diabetic control rats. Further, antioxidants were lowered in diabetic control rats. A significant (p<0.05) decline in glycogen level in the liver and muscle and glycogen synthase activity in the liver and a significant (p<0.05) increase in the activity of liver glycogen phosphorylase were observed in diabetic control rats compared to normal control rats. Oral administration of tyrosol to diabetic rats reversed all the above mentioned biochemical parameters to near normal in a dose dependent manner. Tyrosol at a dose of 20mg/kg body weight showed the highest significant effect than the other two doses. Immunohistochemical staining of pancreas revealed that tyrosol treated diabetic rats showed increased insulin immunoreactive β-cells, which confirmed the biochemical findings. The observed results were compared with glibenclamide, a standard oral hypoglycemic drug.
CONCLUSIONS:
The results of the present study suggest that tyrosol decreases hyperglycemia, by its antioxidant effect.
20(R)-Ginsenoside Rg3

Catalog No: CFN98170
CAS No: 38243-03-7
Price: $60/20mg
Aristolochic acid A

Catalog No: CFN99505
CAS No: 313-67-7
Price: $80/20mg
Parishin E

Catalog No: CFN93115
CAS No: 952068-57-4
Price: $298/20mg
Luteolin 7-diglucuronide

Catalog No: CFN70468
CAS No: 96400-45-2
Price: $ / mg
Terpineol

Catalog No: CFN92688
CAS No: 98-55-5
Price: $30/20mg
Ginsenoside Compound K

Catalog No: CFN99756
CAS No: 39262-14-1
Price: $30/20mg
3-O-beta-D-Glucopyranosylplatycodi...

Catalog No: CFN90950
CAS No: 38337-25-6
Price: $268/5mg
Celastrol

Catalog No: CFN99198
CAS No: 34157-83-0
Price: $40/20mg
Crocin I

Catalog No: CFN99927
CAS No: 94238-00-3
Price: $100/20mg
Glycitin

Catalog No: CFN99105
CAS No: 40246-10-4
Price: $70/20mg
Tags: buy Butanol | Butanol supplier | purchase Butanol | Butanol cost | Butanol manufacturer | order Butanol | Butanol distributor