Ustusolate C | CAS:1188398-15-3 | Manufacturer ChemFaces

Ustusolate C

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Description:

Ustusolate C and ustusolate E exhibit moderate cytotoxicity against A549 and HL-60 cells with IC50 values of 10.5 and 9.0 microM, respectively.

In vitro:

J Nat Prod. 2009 Oct;72(10):1761-7.

Sesquiterpenoids and benzofuranoids from the marine-derived fungus Aspergillus ustus 094102.[Pubmed: 19769341]

METHODS AND RESULTS:
Eight drimane sesquiterpenes (1-8), six isochromane derivatives (9-14), and three known compounds, daldinin B (15), 9alpha-hydroxy-6beta-[(2E,4E,6E)-octa-2,4,6-trienoyloxy]-5alpha-drim-7-en-11,12-olide (16), and pergillin (17), were isolated from the EtOAc extract of the marine-derived fungus Aspergillus ustus 094102. The structures of the new compounds were elucidated on the basis of spectroscopic analysis. The cytotoxic effects on A549 and HL-60 cell lines were evaluated by SRB and MTT methods.
CONCLUSIONS:
Ustusorane E (13) showed significant cytotoxicity against HL-60 cells with an IC50 value of 0.13 microM. Ustusolate C (6) and Ustusolate E (8) exhibited moderate cytotoxicity against A549 and HL-60 cells with IC50 values of 10.5 and 9.0 microM, respectively, and ustusolate A (4) showed weak cytotoxicity against HL-60 and A549 cells with IC50 values of 20.6 and 30.0 microM, respectively.

Ustusolate C Description

Source:	From Aspergillus ustus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Ustusolate C
Price:
CAS No.:	1188398-15-3
Catalog No.:	CFN96461
Molecular Formula:	C₂₃H₃₂O₆
Molecular Weight:	404.50 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Oil
Source:	From Aspergillus ustus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Cytotoxic Compound Library Sesquiterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.4722 mL	12.3609 mL	24.7219 mL	49.4438 mL	61.8047 mL
5 mM	0.4944 mL	2.4722 mL	4.9444 mL	9.8888 mL	12.3609 mL
10 mM	0.2472 mL	1.2361 mL	2.4722 mL	4.9444 mL	6.1805 mL
50 mM	0.0494 mL	0.2472 mL	0.4944 mL	0.9889 mL	1.2361 mL
100 mM	0.0247 mL	0.1236 mL	0.2472 mL	0.4944 mL	0.618 mL

CFN96920	Drimenol	468-68-8	222.37	C₁₅H₂₆O
CFN89495	11-Hydroxydrim-7-en-6-one	74635-87-3	236.34	C₁₅H₂₄O₂
CFN96921	9alpha,11-Dihydroxydrim-7-en-6-one	127681-58-7	252.35	C₁₅H₂₄O₃
CFN89464	2alpha,9alpha,11-Trihydroxy-6-oxodrim-7-ene	1175543-03-9	268.34	C₁₅H₂₄O₄
CFN89442	Ustusol A	1175543-02-8	268.34	C₁₅H₂₄O₄
CFN96972	Albrassitriol	110557-39-6	254.37	C₁₅H₂₆O₃
CFN89042	6-epi-Albrassitriol	178456-58-1	254.37	C₁₅H₂₆O₃
CFN89094	9alpha,11,12-Trihydroxydrim-7-en-6-one	192566-65-7	268.35	C₁₅H₂₄O₄
CFN89169	12-Hydroxy-6-epi-albrassitriol	178330-78-4	270.36	C₁₅H₂₆O₄
CFN96463	Ustusol C	1188398-13-1	284.39	C₁₆H₂₈O₄