Science | Nature | Cell | View More
Natural Products
Vicenin -1
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Vicenin -1
Price: $268 / 20mg
CAS No.: 35927-38-9
Catalog No.: CFN92030
Molecular Formula: C26H28O14
Molecular Weight: 564.5 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow powder
Source: The herbs of Vitex negundo L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $102.0 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Universidade Federal de Pernamb... (Brazil)
  • Celltrion Chemical Research Ins... (Korea)
  • University of Medicine and Phar... (Romania)
  • Universite de Lille1 (France)
  • Molecular Biology Institute of ... (Spain)
  • Shanghai Institute of Biochemis... (China)
  • Technical University of Denmark (Denmark)
  • University of British Columbia (Canada)
  • Univerzita Karlova v Praze (Czech Republic)
  • University of Helsinki (Finland)
  • The University of Newcastle (Australia)
  • More...
Package
Featured Products
Cyclocurcumin

Catalog No: CFN95103
CAS No: 153127-42-5
Price: $338/10mg
11-Hydroxy-sugiol

Catalog No: CFN90366
CAS No: 88664-08-8
Price: $490/5mg
Gentisic acid

Catalog No: CFN92451
CAS No: 490-79-9
Price: $40/20mg
Neochamaejasmine B

Catalog No: CFN92152
CAS No: 90411-12-4
Price: $318/5mg
Swertiajaponin

Catalog No: CFN90652
CAS No: 6980-25-2
Price: $218/10mg
Alstonine

Catalog No: CFN97709
CAS No: 642-18-2
Price: $ /
3-Hydroxy-4-methoxycinnamic acid

Catalog No: CFN99135
CAS No: 537-73-5
Price: $30/20mg
Theaflavin 3,3'-di-O-gallate

Catalog No: CFN99130
CAS No: 30462-35-2
Price: $268/20mg
Allicin

Catalog No: CFN90201
CAS No: 539-86-6
Price: $50/20mg
Echinocystic acid

Catalog No: CFN98812
CAS No: 510-30-5
Price: $60/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Vicenin-1 possesses potent anti-inflammatory and anti-oxidant activity.
Targets: Aldose reductase
In vitro:
Journal of the Korean Society for Applied Biological Chemistry, 2015, 58(3):365-371.
Plant-derived molecules from Saussurea grandifolia as inhibitors of aldose reductase.[Reference: WebLink]
Saussurea grandifolia was tested for aldose reductase (AR) inhibition as part of a search for potentially therapeutic natural compounds.
METHODS AND RESULTS:
Stepwise polarity fractions were tested for in vitro inhibition of rat lens AR. Of these, the ethyl acetate (EtOAc) and n-butanol (n-BuOH) fractions exhibited AR inhibitory activities. A chromatographic separation of the active EtOAc and n-BuOH fractions led to the isolation of nine compounds, which were known and identified as vitexin (1), genkwanin-5-O-glucoside (2), vitexin 2″-p-hydroxybenzoate (3), kaempferol-3-O-rutinoside (4), isovitexin (5), quercitrin (6), isoquercitrin (7), 1,5-di-O-caffeoylquinic acid (8), and Vicenin -1 (9). Among these compounds, compounds 6, 7, and 8 showed very strong inhibitory activities against AR (IC50’s = 0.34, 0.32, and 0.08 μM, respectively).
CONCLUSIONS:
The results suggest that S. grandifolia is clearly a potential source for therapeutic agent that might be useful for the treatment of diabetic complications.
Vicenin -1 Description
Source: The herbs of Vitex negundo L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Momordicine V

Catalog No: CFN95164
CAS No: 1012315-36-4
Price: $463/5mg
Iristectorin A

Catalog No: CFN95037
CAS No: 37744-61-9
Price: $318/20mg
Isoformononetin

Catalog No: CFN95024
CAS No: 486-63-5
Price: $288/5mg
3'-Methoxymirificin

Catalog No: CFN95112
CAS No: 1297609-29-0
Price: $318/5mg
Astin A

Catalog No: CFN95187
CAS No: 151201-75-1
Price: $318/10mg
6-O-(E)-Caffeoylglucopyranose

Catalog No: CFN95105
CAS No: 209797-79-5
Price: $298/5mg
Cassiaglycoside II

Catalog No: CFN95130
CAS No: 2241081-56-9
Price: $368/5mg
Clemomandshuricoside B

Catalog No: CFN95302
CAS No: 905294-48-6
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7715 mL 8.8574 mL 17.7148 mL 35.4296 mL 44.287 mL
5 mM 0.3543 mL 1.7715 mL 3.543 mL 7.0859 mL 8.8574 mL
10 mM 0.1771 mL 0.8857 mL 1.7715 mL 3.543 mL 4.4287 mL
50 mM 0.0354 mL 0.1771 mL 0.3543 mL 0.7086 mL 0.8857 mL
100 mM 0.0177 mL 0.0886 mL 0.1771 mL 0.3543 mL 0.4429 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Animal Research:
Regulatory Toxicology and Pharmacology, 2016:S0273230016303026.
Acute and repeated doses (28 days) oral toxicity study of Vicenin-1, a flavonoid glycoside isolated from fenugreek seeds in laboratory mice.[Reference: WebLink]
Vicenin -1 (fenugreek glycoside) has been proven to possess potent anti-inflammatory and anti-oxidant activity. The objective of the present investigation was to determine in-vivo acute and subacute (28-days repeated dose) oral toxicity of Vicenin -1 isolated from fenugreek seed.
METHODS AND RESULTS:
Vicenin-1 (93%) was isolated from a hydroalcoholic extract of fenugreek seed and characterized using HPLC, TLC, 1H NMR and 13C NMR. Acute oral toxicity (AOT) and subacute toxicity studies of Vicenin -1 were carried out according to OECD 425 (up-and-down procedure) and OCED 407 guidelines in Swiss albino mice. In AOT, Vicenin -1showed 10% mortality when administered at a dose of 5000 mg/kg. However, when vicenin-1 was administered for at doses of 37.5, 75, or 150 mg/kg 28-days it did not show any mortality at the administered doses. Vicenin -1 (75 mg/kg) did not show observational, behavioral, biochemical or histopathological toxic effects. There were minor alterations in body weight, hematology, and histopathology of mice administered with Vicenin -1 (150 mg/kg), but these changes were within normal laboratory ranges. The highest concentration of Venicin-1 was found in liver (3.46%) followed by lung (0.65%).
CONCLUSIONS:
In conclusion, Vicenin -1 showed median lethal dose (LD50) of 4837.5 mg/kg with no-observed-adverse-effect levels (NOAEL) at 75 mg/kg and lowest adverse effect levels (LOAEL) at 150 mg/kg for both sexes of mice during AOT and sub-acute toxicity study, respectively.
Cyclocurcumin

Catalog No: CFN95103
CAS No: 153127-42-5
Price: $338/10mg
11-Hydroxy-sugiol

Catalog No: CFN90366
CAS No: 88664-08-8
Price: $490/5mg
Gentisic acid

Catalog No: CFN92451
CAS No: 490-79-9
Price: $40/20mg
Neochamaejasmine B

Catalog No: CFN92152
CAS No: 90411-12-4
Price: $318/5mg
Swertiajaponin

Catalog No: CFN90652
CAS No: 6980-25-2
Price: $218/10mg
Alstonine

Catalog No: CFN97709
CAS No: 642-18-2
Price: $ /
3-Hydroxy-4-methoxycinnamic acid

Catalog No: CFN99135
CAS No: 537-73-5
Price: $30/20mg
Theaflavin 3,3'-di-O-gallate

Catalog No: CFN99130
CAS No: 30462-35-2
Price: $268/20mg
Allicin

Catalog No: CFN90201
CAS No: 539-86-6
Price: $50/20mg
Echinocystic acid

Catalog No: CFN98812
CAS No: 510-30-5
Price: $60/20mg
Tags: buy Vicenin -1 | Vicenin -1 supplier | purchase Vicenin -1 | Vicenin -1 cost | Vicenin -1 manufacturer | order Vicenin -1 | Vicenin -1 distributor