Vindesine | CAS:53643-48-4 | Manufacturer ChemFaces

Vindesine

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Vindesine is a microtubule inhibitor and widely used to treat malignancies. Vindesine neuropathy seems to be the cause of the patient's neurological symptoms.

In vivo:

J Pediatr Hematol Oncol. 2012 Apr;34(3):239-41.

Successful alternative treatment containing vindesine for acute lymphoblastic leukemia with Charcot-Marie-Tooth disease.[Pubmed: 22246157]

Peripheral neuropathy is a well-known side effect of vincristine (VCR), a microtubule inhibitor commonly used to treat malignancies.
METHODS AND RESULTS:
Severe neurological adverse events can occur in patients with Charcot-Marie-Tooth disease (CMT) treated with VCR. Vindesine is also a microtubule inhibitor, which, like VCR, is widely used to treat malignancies. The case of an 11-year-old female patient with CMT type 1A who developed severe peripheral neuropathy induced by VCR given for her acute lymphoblastic leukemia is reported.
CONCLUSIONS:
Alternative treatment containing Vindesine instead of VCR led to a successful outcome without a relapse of leukemia or neurological worsening of CMT.

Leuk Res. 2009 Dec;33(12):e232-3.

Vindesine-induced neuropathy mimicking Guillain-Barré syndrome.[Pubmed: 19428104]

METHODS AND RESULTS:
A 13-year-old girl with acute lymphoblastic leukaemia, who was being treated with chemotherapy (including Vindesine), developed paraplegia without paresthesia, which mimic Guillain-Barré syndrome.
CONCLUSIONS:
Spinal fluid analysis showed a normal protein level, Vindesine neuropathy seemed to be the cause of the patient's neurological symptoms.The patient seemed to benefit from human normal immunoglobulin therapy and recovered 4 weeks later.

Vindesine Description

Source:	The herbs of Catharanthus roseus (L.) G. Don
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Vindesine
Price:
CAS No.:	53643-48-4
Catalog No.:	CFN90465
Molecular Formula:	C₄₃H₅₅N₅O₇
Molecular Weight:	753.92 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Cryst.
Source:	The herbs of Catharanthus roseus (L.) G. Don
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Inhibitors Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.3264 mL	6.632 mL	13.264 mL	26.528 mL	33.16 mL
5 mM	0.2653 mL	1.3264 mL	2.6528 mL	5.3056 mL	6.632 mL
10 mM	0.1326 mL	0.6632 mL	1.3264 mL	2.6528 mL	3.316 mL
50 mM	0.0265 mL	0.1326 mL	0.2653 mL	0.5306 mL	0.6632 mL
100 mM	0.0133 mL	0.0663 mL	0.1326 mL	0.2653 mL	0.3316 mL

CFN90142	Vinorelbine Tartrate	125317-39-7	1079.11	C₅₃H₆₆N₄O₂₀
CFN90146	Vinblastine Sulfate	143-67-9	909.06	C₄₆H₅₈N₄O₉.H₂SO₄
CFN90230	Vinblastine	865-21-4	810.96	C₄₆H₅₈N₄O₉
CFN90246	3',4'-Anhydrovinblastine	38390-45-3	792.96	C₄₆H₅₆N₄O₈
CFN90400	Vincristine sulfate	2068-78-2	923.04	C₄₆H₅₈N₄O₁₄S
CFN90401	Vinorelbine	71486-22-1	778.93	C₄₅H₅₄N₄O₈
CFN90465	Vindesine	53643-48-4	753.92	C₄₃H₅₅N₅O₇
CFN90466	Vinleurosine	23360-92-1	808.95	C₄₆H₅₆N₄O₉
CFN98589	Vincristine	57-22-7	824.96	C₄₆H₅₆N₄O₁₀