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Voleneol
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Product Name Voleneol
Price:
CAS No.: 70389-88-7
Catalog No.: CFN97192
Molecular Formula: C15H26O2
Molecular Weight: 238.4 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Powder
Source: The herbs of Curcuma wenyujin
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Biological Activity
Description: 1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-dependently suppress the protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2),suggest thats DE may be a good candidate to regulate LPS-induced inflammatory response.
Targets: NO | PGE | NOS | COX
In vitro:
Korean Journal of Pharmacognosy, 2015, 46(1): 12-6.
Anti-inflammatory effects of 1β‚6α-dihydroxyeudesm-4(15)-ene isolated from Myrrh on LPS-induced neuroinflammation in BV2 cells[Reference: WebLink]
Myrrh is a resinous substance obtained from Commiphora trees, which has long been used as an antiseptic agent.A sesquiterpene, 1β, 6α-dihydroxyeudesm-4(15)-ene (DE,Voleneol), was isolated from the hot water extract of Myrrh.
METHODS AND RESULTS:
In the presentstudy, we found that DE attenuates the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells. DE significantlyinhibited LPS-induced production of pro-inflammatory mediators such as nitric oxide (NO) and prostaglandin E2(PGE2) in BV2 microglia in a concentration-dependent manner without cytotoxic effect. Furthermore, DE dose-dependentlysuppressed the protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
CONCLUSIONS:
These results suggest that DE may be a good candidate to regulate LPS-induced inflammatory response.
Voleneol Description
Source: The herbs of Curcuma wenyujin
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.1946 mL 20.9732 mL 41.9463 mL 83.8926 mL 104.8658 mL
5 mM 0.8389 mL 4.1946 mL 8.3893 mL 16.7785 mL 20.9732 mL
10 mM 0.4195 mL 2.0973 mL 4.1946 mL 8.3893 mL 10.4866 mL
50 mM 0.0839 mL 0.4195 mL 0.8389 mL 1.6779 mL 2.0973 mL
100 mM 0.0419 mL 0.2097 mL 0.4195 mL 0.8389 mL 1.0487 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Zhongguo Zhong Yao Za Zhi. 2007 Dec;32(24):2604-6.
Chemical constituents from aerial part of Curcuma wenyujin.[Pubmed: 18338597]
To investigate the chemical constituents from aerial part of Curcuma wenyujin.
METHODS AND RESULTS:
Compounds were isolated by repeated column chromatography on silica gel. Their structures were elucidated on the basis of spectral analysis and comparison with literature data. Six compounds were isolated and identified as codonolactone (1), Voleneol (2), octacosanoic acid (3), beta-sitosterol (4), mangdesisterol (5), and daucosterol (6).
CONCLUSIONS:
Compounds 1, 2, and 5 were isolated from the plant for the first time.
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