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Wilfornine A
Wilfornine A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Wilfornine A
Price: $598 / 5mg
CAS No.: 345954-00-9
Catalog No.: CFN92120
Molecular Formula: C45H51NO20
Molecular Weight: 925.9 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Powder
Source: The roots of Tripterygium wilfordii Hook. f.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $994.0 / In-stock
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Our products had been exported to the following research institutions and universities, And still growing.
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Wilfornine A is a natural product from Schisandra sphenanthera.
Wilfornine A Description
Source: The roots of Tripterygium wilfordii Hook. f.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.08 mL 5.4002 mL 10.8003 mL 21.6006 mL 27.0008 mL
5 mM 0.216 mL 1.08 mL 2.1601 mL 4.3201 mL 5.4002 mL
10 mM 0.108 mL 0.54 mL 1.08 mL 2.1601 mL 2.7001 mL
50 mM 0.0216 mL 0.108 mL 0.216 mL 0.432 mL 0.54 mL
100 mM 0.0108 mL 0.054 mL 0.108 mL 0.216 mL 0.27 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
J Nat Prod. 2001 May;64(5):582-7.
Immunosuppressive sesquiterpene alkaloids from Tripterygium wilfordii.[Pubmed: 11374948]
Nine new sesquiterpene pyridine alkaloids [Wilfornine A (1), wilfornine B (2), wilfornine C (3), wilfornine D (4), wilfornine E (5), wilfornine F (8), and wilfornine G (9); wilfordinines I (6) and J (7)] and six known compounds (10-15) were isolated from a clinically used extract (T(II)) of Tripterygium wilfordii.
METHODS AND RESULTS:
The structures of 1-9 were elucidated by spectroscopic and chemical methods. The inhibitory effects on cytokine production of 1-3 and several related compounds were evaluated. Compounds 10 and 14 showed significant inhibitory effects on cytokine production.
CFN92120Wilfornine A345954-00-9925.9C45H51NO20
CFN99207Wilforine11088-09-8867.9 C43H49NO18
CFN92121Alatamine41855-33-8839.8C41H45NO18
CFN92103Wilfordine37239-51-3883.9C43H49NO19
CFN92104Peritassine A150881-01-9805.8C38H47NO18
CFN92118Ebenifoline E-II133740-16-6929.9C48H51NO18
CFN92119Mayteine104736-05-2867.9C43H49NO18
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