Zeylasteral | CAS:87064-16-2 | Manufacturer ChemFaces

Zeylasteral

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Description:

Zeylasteral and demethylZeylasteral are 6-oxophenolic triterpenoids isolated from the root of Maytenus blepharodes. Zeylasteral and demethylZeylasteral have antimicrobial activity against Gram-positive bacteria and the yeast Candida albicans.

Targets:

Antifection

In vitro:

Planta Med. 2005 Apr;71(4):313-9.

Antimicrobial activity of 6-oxophenolic triterpenoids. Mode of action against Bacillus subtilis.[Pubmed: 15856406]

Zeylasteral and demethylZeylasteral are 6-oxophenolic triterpenoids isolated from the root of Maytenus blepharodes, which have antimicrobial activity against Gram-positive bacteria and the yeast Candida albicans.
METHODS AND RESULTS:
The time-kill curves for Zeylasteral and demethylZeylasteral at concentrations twice their MICs, against Bacillus subtilis showed that the colony forming units were reduced in 3-log10 and > 4-log10 respectively. This reduction was dependent on inoculum size and the growth phase of cells, and was greater when the compounds were incorporated in the exponential phase, indicating a bacteriolytic effect. Treatment with both agents, particularly with Zeylasteral (20 microg/mL) caused a reduction of optical density at 550 nm. With regard to the synthesis of DNA, RNA, protein and cell wall, the compounds exhibited the fastest inhibition against cell wall synthesis.
CONCLUSIONS:
Thus, the predisposition to lysis, the morphological changes seen by microscopy, and the complete inhibition in the incorporation the N-acetyl-d-[1 - 14C]glucosamine, suggest that the phenolic compounds compromise the cell wall synthesis and/or cytoplasmic membrane.

Zeylasteral Description

Source:	The herbs of Tripterygium wilfordii Hook. f.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Zeylasteral
Price:
CAS No.:	87064-16-2
Catalog No.:	CFN92084
Molecular Formula:	C₃₀H₃₈O₆
Molecular Weight:	494.6 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The herbs of Tripterygium wilfordii Hook. f.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antibacterial Compound Library Antifungal Compound Library Triterpenoids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0218 mL	10.1092 mL	20.2184 mL	40.4367 mL	50.5459 mL
5 mM	0.4044 mL	2.0218 mL	4.0437 mL	8.0873 mL	10.1092 mL
10 mM	0.2022 mL	1.0109 mL	2.0218 mL	4.0437 mL	5.0546 mL
50 mM	0.0404 mL	0.2022 mL	0.4044 mL	0.8087 mL	1.0109 mL
100 mM	0.0202 mL	0.1011 mL	0.2022 mL	0.4044 mL	0.5055 mL

CFN92083	Wilforol A	167882-66-8	466.6	C₂₉H₃₈O₅
CFN92571	Triptotin F	359630-36-7	496.7	C₃₁H₄₄O₅
CFN91639	Populninic acid	120090-56-4	470.69	C₃₀H₄₆O₄
CFN90169	Pristimerin	1258-84-0	464.64	C₃₀H₄₀O₄
CFN99198	Celastrol	34157-83-0	450.61	C₂₉H₃₈O₄
CFN90136	Demethylzeylasteral	107316-88-1	480.60	C₂₉H₃₆O₆
CFN92084	Zeylasteral	87064-16-2	494.6	C₃₀H₃₈O₆
CFN91915	Zeylasterone	78012-25-6	510.62	C₃₀H₃₈O₇
CFN91916	Blepharotriol	849590-42-7	482.61	C₂₉H₃₈O₆
CFN96477	Triptocalline A	201534-10-3	442.64	C₂₈H₄₂O₄