Science | Nature | Cell | View More
Natural Products
alpha-Peltatin
alpha-Peltatin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name alpha-Peltatin
Price:
CAS No.: 568-53-6
Catalog No.: CFN70412
Molecular Formula: C21H20O8
Molecular Weight: 400.4 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The herbs of Podophyllum peltatum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Medical University of South Car... (USA)
  • Universita' Degli Studi Di Cagl... (Italy)
  • University of Otago (New Zealand)
  • Mahidol University (Thailand)
  • Chiang Mai University (Thailand)
  • University of East Anglia (United Kingdom)
  • Universidad Miguel Hernández (Spain)
  • Agricultural Research Organizat... (Israel)
  • Periyar University (India)
  • Celltrion Chemical Research Ins... (Korea)
  • Charles University in Prague (Czech Republic)
  • More...
Package
Featured Products
Euphol

Catalog No: CFN89516
CAS No: 514-47-6
Price: $158/10mg
Myricetin 3-O-galactoside

Catalog No: CFN97817
CAS No: 15648-86-9
Price: $318/10mg
1,1,1-Kestopentaose

Catalog No: CFN93044
CAS No: 59432-60-9
Price: $100/20mg
Ginsenoside Rg6

Catalog No: CFN90565
CAS No: 147419-93-0
Price: $268/5mg
Harpagoside

Catalog No: CFN98147
CAS No: 19210-12-9
Price: $70/20mg
Beta-Sitosterol

Catalog No: CFN99916
CAS No: 83-46-5
Price: $40/20mg
Eurycomalactone

Catalog No: CFN92129
CAS No: 23062-24-0
Price: $358/10mg
Astragaloside II

Catalog No: CFN99173
CAS No: 84676-89-1
Price: $50/20mg
Glucobrassicin

Catalog No: CFN00484
CAS No: 143231-38-3
Price: $ / mg
Atractylenolide II

Catalog No: CFN99945
CAS No: 73069-14-4
Price: $70/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: alpha-Peltatin is a lignan podophyllotoxin, it shows phytotoxicity.
In vitro:
Cancer research, 1983, 43(2):505.
Podophyllotoxin-resistant mutants of Chinese hamster ovary cells: cross-resistance studies with various microtubule inhibitors and podophyllotoxin analogues.[Reference: WebLink]

METHODS AND RESULTS:
The cross-resistances of several mutants of Chinese hamster ovary cells which have been obtained after one and two selection steps in the presence of the microtubule inhibitor podophyllotoxin (PodRI and PodRII mutants, respectively) towards various other inhibitors of microtubule assembly (e.g., colchicine, Colcemid, vinblastine, griseofulvin, maytansine, steganacin, nocodazole, and taxol) have been examined. Based upon their specific patterns of cross-resistance/sensitivity to various microtubule inhibitors, both the PodRI and PodRII classes of mutants appear to be of more than one kind. Studies on the binding of [3H]podophyllotoxin to cytoplasmic extracts indicate that one of the PodRII mutants which has been shown previously to be affected in a Mr 66,000 to 68,000 microtubule-associated protein shows reduced binding of the drug in comparison to the parental PodS and PodRI cells. The different PodRI and PodRII mutants exhibited proportionally increased cross-resistances to various podophyllotoxin analogues (e.g., deoxypodophyllotoxin, epipodophyllotoxin, beta-peltatin, 4'-demethylpodophyllotoxin, alpha-Peltatin, podophyllotoxin-beta-D-glucoside, beta-peltatin-beta-D-glucoside, picropodophyllotoxin, and podophyllic acid) which possess microtubule-inhibitory activity. However, with the exception of one PodRI class of mutant, none of the mutants exhibited any cross-resistance to 4'-demethylepipodophyllotoxin thenylidine-beta-D-glucoside and 4'-demethylepipodophyllotoxin ethylidine-beta-D-glucoside, the 2 podophyllotoxin analogues which lack microtubule-inhibitory activity. The cross-resistance studies with these mutants, which, based upon the biochemical studies and their highly specific patterns of cross-resistance, are presumably affected in microtubules, provide some very novel insights into the mechanisms of action of various microtubule inhibitors.
CONCLUSIONS:
The results presented in this paper also show that the cross-resistance studies with the set of podophyllotoxin-resistant mutants provide a sensitive and highly specific screening procedure for identifying compounds which possess podophyllotoxin-like activity and for investigating the structure-activity relationship among them. The results of structure-activity relationship studies for the various podophyllotoxin analogues examined are discussed.
Pesticide Biochemistry & Physiology, 2002, 72(1):45-54.
Aryltetralin Lignans Inhibit Plant Growth by Affecting the Formation of Mitotic Microtubular Organizing Centers.[Reference: WebLink]
The aryltetralin lignans podophyllotoxin, α-peltatin(alpha-Peltatin), and β-peltatin, their respective O-β--glucosides, and the semisynthetic derivative etoposide were tested for phytotoxicity.
METHODS AND RESULTS:
The aglycones were more potent inhibitors than their respective glucosides, and podophyllotoxin was the most active natural lignan tested. These compounds were more active against rye (Lolium multiflorum L.) and onion (Allium cepa L.) than lettuce (Lactuca sativa L.). The semisynthetic lignan etoposide was more active than any of the natural analogues and was phytotoxic to both monocotyledonous and dicotyledonous species. Inhibition of root growth was the main developmental response observed on plants tested with the lignans. At the cellular level, podophyllotoxin and etoposide caused similar symptoms in actively dividing meristematic cells of onion root tips. All phases of mitosis were inhibited by nearly 50%, relative to the controls. Both compounds also induced abnormal star anaphase chromosomal configurations.
CONCLUSIONS:
While the precise molecular mechanism of action of these compounds remains to be identified in plants, a primary effect is the alteration of the formation of the spindle microtubular organization centers, resulting in the formation of multiple spindle poles and an asymmetrical convergence of the chromosomes.
alpha-Peltatin Description
Source: The herbs of Podophyllum peltatum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Narirutin 4'-glucoside

Catalog No: CFN95421
CAS No: 17257-22-6
Price: $318/10mg
Chamigrenol

Catalog No: CFN95247
CAS No: 19822-80-1
Price: $318/10mg
Oxytroflavoside A

Catalog No: CFN95463
CAS No: 1391144-80-1
Price: $318/5mg
5,6,7,3',4'-Pentamethoxyflavanone

Catalog No: CFN95394
CAS No: 104193-93-3
Price: $318/5mg
Lonicerin

Catalog No: CFN95055
CAS No: 25694-72-8
Price: $168/10mg
Aromadendrene

Catalog No: CFN95074
CAS No: 489-39-4
Price: $40/20mg
Malabaricone C

Catalog No: CFN95475
CAS No: 63335-25-1
Price: $318/10mg
Emodin-8-O-beta-gentiobioside

Catalog No: CFN95132
CAS No: 66466-22-6
Price: $368/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4975 mL 12.4875 mL 24.975 mL 49.95 mL 62.4376 mL
5 mM 0.4995 mL 2.4975 mL 4.995 mL 9.99 mL 12.4875 mL
10 mM 0.2498 mL 1.2488 mL 2.4975 mL 4.995 mL 6.2438 mL
50 mM 0.05 mL 0.2498 mL 0.4995 mL 0.999 mL 1.2488 mL
100 mM 0.025 mL 0.1249 mL 0.2498 mL 0.4995 mL 0.6244 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Química Nova, 2001, 24(6):730-733.
Lignans and triterpenes from cytotoxic extract of Eriope blanchetii.[Reference: WebLink]

METHODS AND RESULTS:
This phytochemical study performed with the cytotoxic chloroformic extract of Eriope blanchetii (Benth.) Harley was the first work with this species and describes from aerial parts the isolation of two lignans of podophylotoxin type named β-peltatin and α-peltatin(alpha-Peltatin). Besides them it was obtained four triterpenes; oleanolic acid, ursolic acid, 2α,3β-dihydroxy-urs-12-en-28-olic acid, 2α,3β,19α-trihydroxy-urs-12-en-28-olic acid, named tormentic acid and 3β-glucosyl-sitosterol. The compounds were identified by analysis of their spectral data.
Euphol

Catalog No: CFN89516
CAS No: 514-47-6
Price: $158/10mg
Myricetin 3-O-galactoside

Catalog No: CFN97817
CAS No: 15648-86-9
Price: $318/10mg
1,1,1-Kestopentaose

Catalog No: CFN93044
CAS No: 59432-60-9
Price: $100/20mg
Ginsenoside Rg6

Catalog No: CFN90565
CAS No: 147419-93-0
Price: $268/5mg
Harpagoside

Catalog No: CFN98147
CAS No: 19210-12-9
Price: $70/20mg
Beta-Sitosterol

Catalog No: CFN99916
CAS No: 83-46-5
Price: $40/20mg
Eurycomalactone

Catalog No: CFN92129
CAS No: 23062-24-0
Price: $358/10mg
Astragaloside II

Catalog No: CFN99173
CAS No: 84676-89-1
Price: $50/20mg
Glucobrassicin

Catalog No: CFN00484
CAS No: 143231-38-3
Price: $ / mg
Atractylenolide II

Catalog No: CFN99945
CAS No: 73069-14-4
Price: $70/20mg
Tags: buy alpha-Peltatin | alpha-Peltatin supplier | purchase alpha-Peltatin | alpha-Peltatin cost | alpha-Peltatin manufacturer | order alpha-Peltatin | alpha-Peltatin distributor