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alpha-Terthienylmethanol
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Product Name alpha-Terthienylmethanol
Price:
CAS No.: 13059-93-3
Catalog No.: CFN99395
Molecular Formula: C13H10OS3
Molecular Weight: 278.4 g/mol
Purity: >=98%
Type of Compound: Thiophenes
Physical Desc.: Yellow powder
Source: The herbs of Eclipta alba
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Alpha-terthienylmethanol possesses potent cytotoxic activity against human endometrial cancer cells; it inhibits growth mediated by the induction of apoptosis, as shown by the accumulation of sub-G1 and apoptotic cells.
Targets: NADPH-oxidase | ROS
In vitro:
J Ethnopharmacol. 2015 May 1.
α-Terthienylmethanol, isolated from Eclipta prostrata, induces apoptosis by generating reactive oxygen species via NADPH oxidase in human endometrial cancer cells.[Pubmed: 25940205]
Eclipta prostrate L. (syn. E. alba Hassk), commonly known as False Daisy, has been used in traditional medicine in Asia to treat a variety of diseases, including cancer. Although an anti-tumor effect has been suggested for E. prostrata, the exact anti-tumor effects and underlying molecular mechanisms of its bioactive compounds are poorly understood. The aim of this study was to identify compounds with anti-cancer activity from E. prostrata and to investigate their mechanism of action.
METHODS AND RESULTS:
To assess cell viability, cell cycle progression, and apoptosis, we performed MTT assays and FACS analysis using Annexin and PI staining. We also investigated reactive oxygen species (ROS) production and caspase activation using flow cytometry and Western blot analysis, respectively. Cytosolic translocation of cytochrome c was measured using an ELISA kit. Antioxidants, MAPK signaling inhibitors, NADPH oxidase inhibitors, and siRNA were used to elucidate the molecular mechanism of action of the compound. We isolated five terthiophenes from the n-hexane fraction of E. prostrata; of these, α-terthienylmethanol possessed potent cytotoxic activity against human endometrial cancer cells (Hec1A and Ishikawa) (IC50<1μM). The growth inhibitory effect of alpha-Terthienylmethanol was mediated by the induction of apoptosis, as shown by the accumulation of sub-G1 and apoptotic cells. In addition, alpha-Terthienylmethanol triggered caspase activation and cytochrome c release into the cytosol in a time-dependent manner. Moreover, alpha-Terthienylmethanol increased the intracellular level of ROS and decreased that of GSH, and the antioxidants N-acetyl-l-cysteine and catalase significantly attenuated alpha-Terthienylmethanol-induced apoptosis. We further demonstrated that inhibition of the NADPH oxidase attenuated alpha-Terthienylmethanol-induced cell death and ROS accumulation in endometrial cancer cells.
CONCLUSIONS:
Overall, these results suggest that alpha-Terthienylmethanol, a naturally occurring terthiophene isolated from E. prostrata, induces apoptosis in human endometrial cancer cells by ROS production, partially via NADPH oxidase.
alpha-Terthienylmethanol Description
Source: The herbs of Eclipta alba
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.592 mL 17.9598 mL 35.9195 mL 71.8391 mL 89.7989 mL
5 mM 0.7184 mL 3.592 mL 7.1839 mL 14.3678 mL 17.9598 mL
10 mM 0.3592 mL 1.796 mL 3.592 mL 7.1839 mL 8.9799 mL
50 mM 0.0718 mL 0.3592 mL 0.7184 mL 1.4368 mL 1.796 mL
100 mM 0.0359 mL 0.1796 mL 0.3592 mL 0.7184 mL 0.898 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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