Science | Nature | Cell | View More
Natural Products
threo-Guaiacylglycerol beta-coniferyl ether
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name threo-Guaiacylglycerol beta-coniferyl ether
Price: $413 / 5mg
CAS No.: 869799-76-8
Catalog No.: CFN97431
Molecular Formula: C20H24O7
Molecular Weight: 376.4 g/mol
Purity: >=98%
Type of Compound: Phenylpropanoids
Physical Desc.: Powder
Source: The stems of Clematis armandii
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $351.1 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Bordeaux (France)
  • Universidade da Beira Interior (Germany)
  • Kazusa DNA Research Institute (Japan)
  • Mahatma Gandhi University (India)
  • CSIRO - Agriculture Flagship (Australia)
  • Gyeongsang National University (Korea)
  • The Vancouver Prostate Centre (... (Canada)
  • University of Hertfordshire (United Kingdom)
  • University of Perugia (Italy)
  • Charles Sturt University (Denmark)
  • Universidade Federal de Santa C... (Brazil)
  • More...
Package
Featured Products
Isoscoparin-2''-Beta-D-glucopyrano...

Catalog No: CFN90900
CAS No: 97605-25-9
Price: $238/5mg
Brazilin

Catalog No: CFN98711
CAS No: 474-07-7
Price: $118/20mg
Taurocholic acid

Catalog No: CFN96646
CAS No: 81-24-3
Price: $ / mg
Corynantheine

Catalog No: CFN92843
CAS No: 18904-54-6
Price: $ / mg
Eupatilin

Catalog No: CFN90190
CAS No: 22368-21-4
Price: $68/20mg
N-p-trans-Coumaroyltyramine

Catalog No: CFN98494
CAS No: 36417-86-4
Price: $268/10mg
Santamarine

Catalog No: CFN98667
CAS No: 4290-13-5
Price: $ /
Noroxyhydrastinine

Catalog No: CFN90504
CAS No: 21796-14-5
Price: $318/5mg
Madecassic acid

Catalog No: CFN99914
CAS No: 18449-41-7
Price: $30/20mg
Cyanidin-3-O-(6''-malonylglucoside...

Catalog No: CFN91864
CAS No: 171828-62-9
Price: $613/5mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Threo-Guaiacylglycerol beta-coniferyl ether displays significant inhibitory effects on NO production.
Targets: NO
In vitro:
J Ethnopharmacol. 2014 May 14;153(3):737-43.
Lignans from the stems of Clematis armandii ([Pubmed: 24661966]
The dried stems of Clematis armandii (Caulis clematidis armandii), named "Chuan-Mu-Tong" in Chinese Pharmacopoeia, have been traditionally used as an herbal remedy mainly for inflammation-associated diseases. The Aim of the study is to identify the potential anti-neuroinflammatory components from Clematis armandii.
METHODS AND RESULTS:
The ethanol extract of "Chuan-Mu-Tong" was suspended in H₂O and exhaustively extracted with CH₂Cl₂. The CH₂Cl₂ fraction was successively subjected to column chromatography (CC) over silica gel, Sephadex LH-20, and semi-preparative HPLC. The structures of the isolated compounds were identified by spectroscopic methods and by comparison with those reported in the literature. Their anti-neuroinflammatory activities were evaluated by inhibitory effects on pro-inflammatory mediators [e.g. nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α)] in lipopolysaccharide (LPS)-activated BV-2 cells. One new and sixteen known lignans were isolated and characterized. The absolute configuration of the new lignan, (7R,8S)-9-acetyl-dehydrodiconiferyl alcohol (1), was elucidated by a combination of 1D/2D NMR techniques and the Electronic Circular Dichroism (ECD) spectroscopy based on the empirical helicity rules. The anti-neuroinflammatory bioassay showed that compounds 1, (7R,8S)-dehydrodiconiferyl alcohol (2), threo-Guaiacylglycerol beta-coniferyl ether (5), and threo-guaiacylglycerol-β-coniferyl ether (6) displayed significant inhibitory effects on NO production. Among them, neolignans 1 and 2 exhibited more potent activities than the positive control (N(G)-monomethyl-L-arginine, L-NMMA), with an IC₅₀ value of 9.3 and 3.9 μM, respectively. Moreover, both 1 and 2 were also found to concentration-dependently suppress the TNF-α release in LPS-stimulated BV-2 cells.
CONCLUSIONS:
The results revealed that lignans are the major components of "Chuan-Mu-Tong", and their anti-neuroinflammatory activities strongly support the traditional application of this herb medicine on inflammation. Moreover, the dihydrobenzo[b]furan neolignans 1 and 2 as well as Caulis clematidis armandii could be further exploited as new therapeutic agents to treat inflammation-mediated neurodegenerative and aging-associated diseases.
threo-Guaiacylglycerol beta-coniferyl ether Description
Source: The stems of Clematis armandii
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Isomargaritene

Catalog No: CFN95304
CAS No: 64271-11-0
Price: $318/10mg
2-Cinnamoyl-1-galloylglucose

Catalog No: CFN95098
CAS No: 56994-83-3
Price: $338/5mg
Leachianol F

Catalog No: CFN95147
CAS No: 164123-50-6
Price: $318/5mg
2-Methoxy-1,4-naphthoquinone

Catalog No: CFN95269
CAS No: 2348-82-5
Price: $70/20mg
Arisanschinin E

Catalog No: CFN95221
CAS No: 1333378-33-8
Price: $ / mg
3beta-Hydroxyurs-12,18-dien-28-oic...

Catalog No: CFN95461
CAS No: 434942-42-4
Price: $318/5mg
3-Methoxyshancigusin I

Catalog No: CFN95062
CAS No: N/A
Price: $413/5mg
Tortoside B (Manglieside E)

Catalog No: CFN95390
CAS No: 190655-17-5
Price: $413/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6567 mL 13.2837 mL 26.5675 mL 53.135 mL 66.4187 mL
5 mM 0.5313 mL 2.6567 mL 5.3135 mL 10.627 mL 13.2837 mL
10 mM 0.2657 mL 1.3284 mL 2.6567 mL 5.3135 mL 6.6419 mL
50 mM 0.0531 mL 0.2657 mL 0.5313 mL 1.0627 mL 1.3284 mL
100 mM 0.0266 mL 0.1328 mL 0.2657 mL 0.5313 mL 0.6642 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Isoscoparin-2''-Beta-D-glucopyrano...

Catalog No: CFN90900
CAS No: 97605-25-9
Price: $238/5mg
Brazilin

Catalog No: CFN98711
CAS No: 474-07-7
Price: $118/20mg
Taurocholic acid

Catalog No: CFN96646
CAS No: 81-24-3
Price: $ / mg
Corynantheine

Catalog No: CFN92843
CAS No: 18904-54-6
Price: $ / mg
Eupatilin

Catalog No: CFN90190
CAS No: 22368-21-4
Price: $68/20mg
N-p-trans-Coumaroyltyramine

Catalog No: CFN98494
CAS No: 36417-86-4
Price: $268/10mg
Santamarine

Catalog No: CFN98667
CAS No: 4290-13-5
Price: $ /
Noroxyhydrastinine

Catalog No: CFN90504
CAS No: 21796-14-5
Price: $318/5mg
Madecassic acid

Catalog No: CFN99914
CAS No: 18449-41-7
Price: $30/20mg
Cyanidin-3-O-(6''-malonylglucoside...

Catalog No: CFN91864
CAS No: 171828-62-9
Price: $613/5mg
Tags: buy threo-Guaiacylglycerol beta-coniferyl ether | threo-Guaiacylglycerol beta-coniferyl ether supplier | purchase threo-Guaiacylglycerol beta-coniferyl ether | threo-Guaiacylglycerol beta-coniferyl ether cost | threo-Guaiacylglycerol beta-coniferyl ether manufacturer | order threo-Guaiacylglycerol beta-coniferyl ether | threo-Guaiacylglycerol beta-coniferyl ether distributor