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    Natural Products
    Catalog No. Information
    CFN98668 3-O-Acetyloleanolic acid

    1. 3-O-Acetyloleanolic acid inhibits proliferation, migration and tube formation of umbilical vein endothelial cells (HUVECs) in a dose-dependent manner; it exhibits anti-angiogenic effects and induces in HUVECs and suggests that it has a potential use for suppression of the stimulated by angiogenesis.
    2. 3-O-Acetyloleanolic acid has inhibition of angiopoietin-1-induced angiogenesis and lymphangiogenesis, it can inhibit VEGF-A-induced lymphangiogenesis and lymph node metastasis in an oral squamous cell carcinoma animal model.
    3. 3-O-Acetyloleanolic acid induces apoptosis in HCT-116 cells mediated by an extrinsic apoptosis signaling cascade via up-regulation of DR5.
    4. 3-O-Acetyloleanolic acid shows a significant decrease in the glucose level of STZ-induced diabetic rats, suggests that it has antihyperglycemic activity.
    CFN98845 3-O-Acetylpinobanksin

    CFN92573 3-O-Caffeoylquinic acid methyl ester

    CFN92393 3-O-Feruloylquinic acid

    1. 3-O-Feruloylquinic acid is a protease inhibitor.
    2. 3-O-Feruloylquinic acid exerts moderate inhibitory effect against AIV (H5N1) in vitro.
    CFN99616 3-O-Methylquercetin

    1. 3-O-Methylquercetin may exert its anti-inflammatory effect through the inhibition of iNOS DNA transcription.
    2. 3-O-Methylquercetin is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low K(m) value.
    3. 3-O-Methylquercetin inhibits total cAMP- and cGMP-phosphodiesterase (PDE) of guinea pig trachealis at low concentrations.
    4. 3-O-Methylquercetin has both anti-inflammatory and bronchodilating effects, and has the potential for use in the treatment of asthma at a dose without affecting blood pressure.
    5. 3-O-Methylquercetin has antiviral activity.
    CFN97843 3-O-trans-p-Coumaroyltormentic acid

    1. 3-O-(E)-p-coumaroyl tormentic acid induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition, it may be promising lead compound for developing an effective drug for treatment of leukemia.
    2. 3-O-trans-p-coumaroyltormentic acid shows cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) in vitro, the IC50 values of 13.72, 14.29,14.61, 14.04 uM, respectively.
    3. 3beta-O-cis-p-Coumaroyltormentic acid, and 3beta-O-trans-p-coumaroyltormentic acid are weakly selective for vancomycin-resistant Enterococcus (VRE) compared with eukaryotic cells, with an MIC of 59.4microg/mL and a 50% inhibitory concentration (IC50) of 72.0microg/mL for monkey kidney epithelial (MA104) cells.
    4. A mixture of 3-O-cis-p-coumaroyltormentic acid and 3-O-trans-p-coumaroyltormentic acid shows an inhibitory effect comparable to (-)-epigallocatechin gallate (EGCG) of green tea on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradeca--noylphorbol-13-acetate (TPA).
    CFN92194 3-oxo-Olean-12-en-28-oic acid

    1. 3-oxo-Olean-12-en-28-oic acid and kulinone have cytotoxic effects, with IC50 values of 5.6-21.2 μg/mL.
    CFN92805 4,4'-Di-O-methylellagic acid

    1. 4,4'-di-O-methylellagic acid is the most effective compound in the inhibition of colon cancer cell proliferation.
    CFN90723 4',7-Isoflavandiol

    1. 4',7-Isoflavandiol, an estrogen metabolite, affects the ability of soy nuts to improve cardiovascular risk factors.
    2. 4',7-Isoflavandiol may advance breast cancer potential via up-regulation of the eukaryotic initiation factor 4GI (eIF4GI).
    3. 4',7-Isoflavandiol is a potential anticancer agent against HeLa, with possible mechanisms involved in ROS generation and mitochondrial membrane alteration.
    CFN97334 4-Epicommunic acid