Screening Libraries
| Cat. | Size | Price | Stock | |
| P20306 | 1mg/well * 10 Compounds | Inquiry | In stock | Contact Us |
| P20306 | 100uL/well (10mM solution) * 10 Compounds | Inquiry | In stock |
| manager@chemfaces.com | |
| Tel | (0086)-27-8423-7683 |
| Shelf Life | (0086)-27-84254680 |
| Manufacturer | Wuhan ChemFaces Biochemical Co., Ltd. |
| Container | 96 Well Format Sample |
| Storage | Protected from air and light, refrigerate or freeze(2-8 °) |
| Shelf Life | 24 months (2-8 °) |
| Intended Use | For research use only. Not for human use. Not sell to patients |
| 1. The products in the ChemFaces screening libraries are all from plants. |
| 2. The biological activities or pharmacological activities of all the ChemFaces products are derived from the databases of all over the world the latest literatures, you can according to the product manuals on our website to access the relevant literatures, hope that our informations can give some inspirations and help to your research. |
| 3.The collections of unique natural products, which include antioxidants, anti-inflammatory, antibacterial, anticancer, and ect. Can be used for high throughput screening (HTS) and high content screening (HCS), is to help you carry out new drug screening, the emergence of new indications and other professional tools. |
| 4.Structurally diverse, medicinally active, and cell permeable, NMR and HPLC validated to ensure high purity. |
| 5. ChemFaces offers customized bioactive screening libraries , whereby you choose the specific compounds you want in the library, the quantities, plate map, concentration, and format (dry/solid or DMSO solution). |
| Catalog No. | Information |
| CFN99985 | Raddeanin A Raddeanin A, a histone deacetylases (HDACs) inhibitor, has high antiangiogenic potency, and antitumor activity, it can suppress the growth of liver and cells, it also inhibits proliferation of GC cells (BGC-823, SGC-7901 and MKN-28), induces their and inhibits the abilities of invasion, migration. |
| CFN99916 | Beta-Sitosterol Beta-Sitosterol is a novel plant-derived angiogenic factor which may have potential pharmaceutical applications for the management of chronic wounds. It has potent anti-inflammatory, anti-proliferation, and pro- apoptosis activities, it also possesses antipyretic activity, similar to acetylsalicylic acid. |
| CFN99786 | Anemoside B4 1. Anemoside B4(AB4) and tetrandrine(Tet) have some reversal effect on resistant to L-OHP in Lo Vo/L-OHP cells, the molecular mechanism of the resistance reverse effect was related to down-regulation of P-gp for AB4 and down-regulation of z DHHC9 for Tet. 2. Anemoside B4 can inhibit the production of IL-6,secretion of IL-8, downregulate E-selectin expression, and decrease the content of TXB(2), it reduces inflammatory response, thus relieving intestinal dysfunction via multiple pathways. 3. Anemoside B4 may potentially have a capacity to regulate immune responses in vivo via changes in production of these select cytokines by infected endothelial cells. |
| CFN98913 | Lupeol 1. Lupeol has a potential to act as an anti-inflammatory, anti-microbial, anti-protozoal, anti-proliferative, anti-invasive, anti-angiogenic, antimalarial and cholesterol lowering agent. 2. Lupeol prevents acetaminophen-induced in vivo hepatotoxicity by altering the Bax/Bcl-2 and oxidative stress-mediated mitochondrial signaling cascade. 3. Lupeol and its ester derivative have beneficial effects on hypercholesterolemia-induced oxidative and inflammatory stresses. 4. Lupeol significantly enhances the radiosensitivity of SMMC-7721 cells in vitro and in vivo. 5. Lupeol shows antidiabetic and antioxidant potential in experimental hyperglycaemia. 6. Lupeol has potential anticancer effect against hepatocellular and pancreatic cancer, by inhibiting cell proliferation, inducing apoptosis and blocking Akt/PI3K and Wnt signaling pathway. 7. Lupeol has antiangiogenic effects, it (at 50 and 30 microg/mL) shows a marked inhibitory activity on human umbilical venous endothelial cells (HUVEC) tube formation while it does not affect the growth of tumor cell lines such as SK-MEL-2, A549, and B16-F10 melanoma. |
| CFN98800 | Oleanolic acid Oleanolic acid is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor, anti-inflammatory, antioxidant, and antiviral properties. Oleanolic acid exhibits anti-HCV activity at least partly through suppressing HCV NS5B RdRp activity as a noncompetitive inhibitor; it induces the upregulation of miR-132, which serves as an important regulator of neurotrophic actions, mainly through the activation of the hippocampal BDNF-ERK-CREB signalling pathways; can be employed as a lead in the development of potent NO inhibitors. Oleanolic acid supplement ameliorates fructose-induced Adipo-IR in rats via the IRS-1/phosphatidylinositol 3-kinase/Akt pathway. |
| CFN98710 | Betulin Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC50 of 14.5 μM in K562 cell line. Betulin has hypoglycemic, antineoplastic, anti-HIV, antimalarial and anti-inflammatory activities. Betulin can improve hyperlipidemia and insulin resistance and reduce atherosclerotic plaques. Betulin inhibits pro-inflammatory cytokines expression and NF-κB signaling activation through STAT3 signaling, it is associated with activation of AMP kinase and inhibition of mTOR/p70S6K/pS6 signaling in these cells. |
| CFN98706 | Betulinic acid Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, immunomodulatory, anti-inflammatory and anti-tumor properties.Betulinic acid is a selective inducer of apoptosis in tumor cells, it inhibits activation of NF-kappaB and NF-kappaB-regulated gene expression induced by carcinogens and inflammatory stimuli. |
| CFN98695 | Hederagenin Hederagenin shows anti-cancer,anti-inflammatory, antidepressant-like ,anticomplementary, and antimutagenic effects, it can evoke hemolysis on the erythrocytes, and has cytotoxic on various tumor cell lines, P-388, L-1210, U-937, HL-60, SNU-5 and HepG2. Hederagenin can inhibit LPS-stimulated expression of iNOS, COX-2, and NF-κB, regulate monoamine neurotransmitters and 5-HTT mRNA expression. |
| CFN98668 | 3-O-Acetyloleanolic acid 3-O-Acetyloleanolic acid exhibits anti-angiogenic effects, it inhibits proliferation, migration and tube formation of umbilical vein endothelial cells (HUVECs) in a dose-dependent manner; it can inhibit VEGF-A-induced lymphangiogenesis and lymph node metastasis in an oral squamous cell carcinoma animal model. 3-O-Acetyloleanolic acid has antihyperglycemic activity, it shows a significant decrease in the glucose level of STZ-induced diabetic rats. |
| CFN90182 | Anemoside A3 Anemoside A3 is an attractive candidate for further development as a cognitive enhancer capable of alleviating memory dysfunctions associated with aging and neurodegenerative diseases. Anemoside A3 also produces relaxation in rat renal arteries through multiple mechanisms. |
