1. Capsaicin, the main pungent ingredient in 'hot' chilli peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system.
2. Treatment of immortalized stromal-like and epithelial-like endometriotic cells with capsaicin resulted in inhibition of proliferation in a concentration-dependent manner, endometriotic cells are more sensitive to capsaicin treatment than immortalized endometrial cells, suggesting that capsaicin may be an admissible drug candidate for treating endometriosis.
3. Capsaicin has antioxidant activity , it is more effective than melatonin in suppressing the formation of lipid hydroperoxides but not as effective as butylated hydroxytoluene(BHT).
4. Capsaicin may used as a pain therapy by the long-lasting and inhibitory effects on persistent pain.
5. Capsaicin reduces anxiety-like behaviours in rats by repeating oral administration and increase corticosterone response, modulate the hippocampal neural plasticity.
1. Histamine increases endothelial permeability and inhibits the ConA-induced ascites, presumably due to its known hypotonic effect.
2. Histamine promotes the pathogenesis of experimental allergic asthma in mice via the Histamine H4 -receptor (H4 R).
3. Histamine increases Nav1.8 expression in primary afferent neurons via H2 receptor-mediated pathway and thereby contributes to neuropathic pain, H2 receptor antagonists may potentially be used as analgesics for patients with neuropathic pain.
1. Tartaric acid, oxalic acid and histamine are the well-recognized pain-inducing agents in the stinging hairs of U. thunbergiana.