1. Capsaicin suppresses the growth of several malignant cell lines.
2. Capsaicin may used as a pain therapy by the long-lasting and inhibitory effects on persistent pain.
3. Capsaicin reduces anxiety-like behaviours in rats by repeating oral administration and increase corticosterone response, modulate the hippocampal neural plasticity.
1. Histamine increases endothelial permeability and inhibits the ConA-induced ascites, presumably due to its known hypotonic effect.
2. Histamine promotes the pathogenesis of experimental allergic asthma in mice via the Histamine H4 -receptor (H4 R).
3. Histamine increases Nav1.8 expression in primary afferent neurons via H2 receptor-mediated pathway and thereby contributes to neuropathic pain, H2 receptor antagonists may potentially be used as analgesics for patients with neuropathic pain.
1. Tartaric acid, oxalic acid and histamine are the well-recognized pain-inducing agents in the stinging hairs of U. thunbergiana.