1. Iriflophenone-3- C -glucoside has antioxidant activity, it presents no radical scavenging ability against DPPH , but scavenges ABTS + and peroxyl radicals (TEAC ABTS of 1.04 and TEAC ORAC of 3.61).
2. Iriflophenone-3-C-β-d-glucoside shows potent inhibitory activity against α-glucosidase.
3. Iriflophenone 3-C-β-D-glucoside and mangiferin which along with 3 β taraxerol and other sterols could be contributing to the cholesterol lowering activity.
1. Ganoderol B is an angiotensin-converting enzyme inhibitor.
2. Ganoderol B is a potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum.
3. Ganoderol B may be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of androgen and its receptor.
1. 3α-Akebonoic acid shows interesting in vitro growth inhibitory activity against human tumor A549 and HeLa cell lines, it also shows significant in vitro α-glucosidase inhibitory activity.
2. 3α-Akebonoic acid can interfer with presenilin-1 (PS1)/ β-site APP-cleaving enzyme 1 (BACE1) interaction and reduces Aβ production, the chemical interference of PS1/BACE1 interaction is a promising strategy for Alzheimer’s disease therapeutics.
1. Balanophonin exhibits cytotoxicity against SGC-7901 and SMMC-7721 cell lines.
2. (-)-Balanophonin shows the significant inhibitory activity on advanced glycation end products (AGEs) formation with values of 27.81uM.
3. Balanophonin shows potent α-glucosidase inhibitory activity.
4. Balanophonin has antioxidant activity.
5. (±)-Balanophonin shows significant antibacterial activity against cariogenic oral streptococci, Streptococcus mutans and S. sobrinus.
1. An isoflavone glycitin is isolated from the licorice, which has good inhibitory effect on α-glucosidase with IC50of 0.5646 mg·mL- 1, better than the position control acarbose.
2. Glycitin, daidzin, and genistin may modulate differentiation of MSC to cause a lineage shift toward the osteoblast and away from the adipocytes, and could inhibit adipocytic transdifferentiation of osteoblasts, they could also be helpful in preventing the development of osteonecrosis.
3. Glycitein has a protective effect on skin aging by inhibiting of MMP-1 and increasing of collagen through ERK/JNK/P38 down-regulation, which may be mediated by the inhibition of ERK, JNK, and p38 mitogen-activated protein kinases, suggests that glycitin is a potential agent for the treatment of skin ageing.
4. A mixture of daidzin and glycitin has anti-obese and anti-diabetic effects on C57BL/6J mice fed with a high-fat diet by the regulation of oxidative stress .