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  • Bioactive Products
    Catalog No. Information
    CFN99067 3alpha-Akebonoic acid

    1. 3α-Akebonoic acid shows interesting in vitro growth inhibitory activity against human tumor A549 and HeLa cell lines, it also shows significant in vitro α-glucosidase inhibitory activity.
    2. 3α-Akebonoic acid can interfer with presenilin-1 (PS1)/ β-site APP-cleaving enzyme 1 (BACE1) interaction and reduces Aβ production, the chemical interference of PS1/BACE1 interaction is a promising strategy for Alzheimer’s disease therapeutics.
    CFN99149 Ginkgolide J

    1. Ginkgolide J can prevent A beta(1-42) induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices, it is also capable of inhibiting cell death of rodent hippocampal neurons caused by A beta(1-42).
    2. Ginkgolide J can inhibit platelet aggregation induced by ADP or PAF.
    3. Ginkgolides (Gins A, B, C and J) have a significant role to protect the primary cortical neurons from hypoxic injury induced by potassium cyanide (KCN).
    CFN99183 (+)-Taxifolin

    1. (+)-Taxifolin is an inhibitor of aggregation of the 42-residue amyloid β-protein, it has preventive effects against Alzheimer's disease-like pathogenesis in vivo.
    2. (+)-Taxifolin is a weak inhibitor of cytochrome b5 reduction (IC50=9.8μM).
    CFN99192 Lipoic acid

    1. Alpha-lipoic acid has become a common ingredient in multivitamin formulas, anti-aging supplements, and even pet food, it is well-defined as a therapy for preventing diabetic polyneuropathies, and scavenges free radicals, chelates metals, and restores intracellular glutathione levels which otherwise decline with age.
    2. Alpha-lipoic acid can enhance glucose transport and utilization in different experimental and animal models, it can improve insulin sensitivity in patients with type-2 diabetes.
    3. Lipoic acid is a novel treatment for Alzheimer's disease and related dementias.
    4. Alpha-lipoic acid has therapeutic effects on joint inflammation and erosion in an animal model via NF-kappa B down regulation, it inhibits TNF-alpha induced NF-kappa B activation through blocking of MEKK1-MKK4-IKK signaling cascades.
    CFN99567 Picroside III

    1. Picrosides exhibit significant learning and memory deficits, just as Alzheimer's disease(AD) in human.