Cinnamic acid, a naturally occurring aromatic fatty acid of low toxicity, has anti-diabetic , anticancer and antioxidant activities. It is a cell differentiation inducer and protein isoprenylation inhibitor, shows a significant radio-protective effect by reducing the DNA damage induced by X-rays. Cinnamic acid inhibited feeding by detritivores, this inhibition occurs at concentrations found in nature and may be a major factor controlling the rate of decay of organic matter. It inhibited mushroom tyrosinase activity in reversiblywith the IC 50 value of 2.10 mM.
Dihydrocapsaicin, a potential inducer of autophagy, has cytotoxic activity. It has anti-atherogenic activity, can reduce the susceptibility of low-density lipoprotein (LDL) to oxidation. Dihydrocapsaicin treatment depletes peptidergic nerve fibers of substance P and alters mast cell density in the respiratory tract of neonatal sheep.
1. Cinnamyl acetate is used as flavor and fragrance ingredient in food and cosmetic industries.
Cinnamyl alcohol could as a fragrance ingredient with no safety concerns, it readily autoxidizes upon air exposure, and forms strong sensitizers as determined by the local lymph node assay.
Cinnamic aldehyde, a COX-2 inhibitor, exhibits cardioprotective, antidepressant-like, anti-leukemia, anti-oxidative and anti-inflammatory properties. Its supplementation can improve glucose and lipid homeostasis in diabetic animals.