Natural Products
Emodin
| Catalog No. | CFN98834 |  |
| CAS No. | 518-82-1 | |
| Molecular Weight: | 270.2 | |
| Molecular Formula | C15H10O5 | |
| DBs | [PubChem]:274951345 [ChEMBL]:42223 [PCIDB]:555 |
Standard InChI:
InChI=1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
Biological Activity
Emodin, a natural anthraquinone derivative isolated from Rheum palmatum L., exhibits anti-cancer effect on several human cancers such as liver cancers and lung cancers, treatment with 50 microM emodin resulted in a pronounced release of cytochrome c, activation of caspase-2, -3, and -9, and apoptosis in human lung adenocarcinoma A549 cells.[1]
Emodin has a strong antimicrobial activity and anti-virus effect , can inhibit HBV DNA replication and HBsAg secretion in HepG2.2.15 cells, may be a new modality to treat hepatitis B infection. [2]
Emodin significantly inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced in vitro invasion of human cancer cells including HSC5 and MDA-MB-231 cells, and inhibits the invasiveness of human cancer cells by suppressing MMP-9 expression through inhibiting AP-1 and NF-kappaB signaling pathways.[3]
Product
References
[1] Su Y T, Chang H L, Shyue S K, et al. Biochem Pharmacol, 2005, 70(2):229–241.
[2] Shuangsuo D, Zhengguo Z, Yunru C, et al. 2006, 12(9):302-6.
[3] Huang Q, Shen H M, Ong C N. Biochem Pharmacol, 2004, 68(2):361-71.
[4] Shi Y B, Shi Y P, Yang Y B, et al. Chromatographia, 2007, 65(9-10):601-606.
Product Use Citation
