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    2,3,24-Trihydroxy-12-ursen-28-oic acid
    Information
    CAS No. 89786-83-4 Price
    Catalog No.CFN97462Purity>=98%
    Molecular Weight488.7 Type of CompoundTriterpenoids
    FormulaC30H48O5Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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  • Biological Activity
    Description: 2α,3α,24-Trihydroxyurs-12-en-28-oic acid, a triterpenoid phytoalexin, shows antifungal activity against the fungus mentioned. It also shows in vitro cytotoxic activity against tumor cell lines including PLC,Hep3B,HepG2,HeLa,SW480,MCF-7 and Bel7402.
    Targets: Antifection
    In vitro:
    Chinese Journal of Natural Medicines, 2010, 8(4):260-3.
    Four Triterpenoids with Cytotoxic Activity from the Leaves of Actinidia valvata[Reference: WebLink]
    To study the chemical constituents of the leaves of Actinidia valvata Dunn.
    METHODS AND RESULTS:
    Several chromatographic methods were applied to isolate and purify compounds and their structures were elucidated by spectroscopic methods. Four triterpenoids including corosolic acid(1),2α,3β,24-trihydroxyurs-12-en-28-oic acid(2,3,24-Trihydroxy-12-ursen-28-oic acid ,2),2α,3α,24-trihydroxyurs-12-en-28-oic acid(3) and 2α,3α,19α,24-tetrahydroxyurs-12-en-28-oic acid(4) were isolated from Actinidia valvata Dunn.They all showed in vitro cytotoxic activity against tumor cell lines including PLC,Hep3B,HepG2,HeLa,SW480,MCF-7 and Bel7402.
    CONCLUSIONS:
    These 4 compounds were all obtained from the plant for the first time.
    2,3,24-Trihydroxy-12-ursen-28-oic acid Description
    Source: The herbs of Callicarpa bodinieri Levl.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0462 mL 10.2312 mL 20.4625 mL 40.9249 mL 51.1561 mL
    5 mM 0.4092 mL 2.0462 mL 4.0925 mL 8.185 mL 10.2312 mL
    10 mM 0.2046 mL 1.0231 mL 2.0462 mL 4.0925 mL 5.1156 mL
    50 mM 0.0409 mL 0.2046 mL 0.4092 mL 0.8185 mL 1.0231 mL
    100 mM 0.0205 mL 0.1023 mL 0.2046 mL 0.4092 mL 0.5116 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Phytochemistry, 1999, 52(4):623-9.
    Triterpene phytoalexins from nectarine fruits[Reference: WebLink]

    METHODS AND RESULTS:
    Seven triterpenoid phytoalexins were isolated from peel of unripe fruits of nectarine (Prunus persica cv Fantasia) wounded and inoculated with Colletotrichum musae. Two were new triterpenoids, identified as 1β,2α,3α,24-tetrahydroxyurs-12-en-28-oic acid and 1β,2α,3α,24-tetrahydroxyolean-12-en-28-oic acid. 2α,3α,24-Trihydroxyolean-12-en-28-oic acid, 2α,3α,24-trihydroxyurs-12-en-28-oic acid(2,3,24-Trihydroxy-12-ursen-28-oic acid), 2α,3β,24-trihydroxyolean-12-en-28-oic acid, 2α,3α-dihydroxyolean-12-en-28-oic acid, and 2α,3α-dihydroxyurs-12-en-28-oic acid were previously reported as constitutive natural products from other plants, but were never described as phytoalexins.
    CONCLUSIONS:
    All showed antifungal activity against the fungus mentioned.