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    4,5-Di-O-caffeoylquinic acid methyl ester
    Information
    CAS No. 188742-80-5 Price $388 / 5mg
    Catalog No.CFN90858Purity>=98%
    Molecular Weight530.5Type of CompoundPhenylpropanoids
    FormulaC26H26O12Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: 4,5-Di-O-caffeoylquinic acid methyl ester shows high efficiency and low toxicity with antivirus activity against RSV.
    Targets: HSV
    In vitro:
    Chinese Traditional & Herbal Drugs, 2015 , 46 (11) :1597-602.
    Study on chemical constituents from Re-Du-Ning Injection (II).[Reference: WebLink]
    To investigate the chemical constituents from Re-Du-Ning Injection (RDN).
    METHODS AND RESULTS:
    The chemical constituents were isolated by chromatography on silica gel, ODS, Sephadex LH-20, and Toyopearl HW-40 columns and reverse phase MPLC and HPLC repeatedly. Their structures were identified by spectral data and physicochemical property. Sixteen compounds were isolated and identified as 5-O-caffeoylquinic acid (1), 5-O-caffeoylquinic acid methyl ester (2), 4-O-caffeoylquinic acid (3), 5-O-caffeoylquinic acid methyl ester (4), 4,5-di-O-caffeoylquinic acid (5), 4,5-Di-O-caffeoylquinic acid methyl ester (6), 3,5- di-O-caffeoylquinic acid (7), 3,5-di-O-caffeoylquinic acid methyl ester (8), 3,4-di-O-caffeoylquinic acid (9), 3,4-di-O-caffeoylquinic acid methyl ester (10), secologanic acid (11), vogeloside (12), 7-epi-vogeloside (13), E-aldosecologanin (14), Z-aldosecologanin (15), and 5H,8H-pyrano[4,3-d] thiazolo[3,2-a] pyridine-3-carboxylic acid (16). Compounds 1-10 showed high efficiency and low toxicity with antivirus activity against RSV.
    CONCLUSIONS:
    All the isolated compounds are reported from RDN Injection for the first time, and caffeoylquinic acids may be one of antivirus pharmacodynamic material bases of RDN.
    4,5-Di-O-caffeoylquinic acid methyl ester Description
    Source: The flowerbud of Lonicera japonica Thunb.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.885 mL 9.4251 mL 18.8501 mL 37.7003 mL 47.1254 mL
    5 mM 0.377 mL 1.885 mL 3.77 mL 7.5401 mL 9.4251 mL
    10 mM 0.1885 mL 0.9425 mL 1.885 mL 3.77 mL 4.7125 mL
    50 mM 0.0377 mL 0.1885 mL 0.377 mL 0.754 mL 0.9425 mL
    100 mM 0.0189 mL 0.0943 mL 0.1885 mL 0.377 mL 0.4713 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.